Effect of a novel soft steroid on the wound healing of rabbit cornea

Bodor, Nicholas; Varga, M.

doi:10.1016/0014-4835(90)90229-n

Cited by 24 publications

(12 citation statements)

References 18 publications

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“…Though various therapeutic substances and surgical procedures have been introduced in the management of alkali-wounded eyes, these interventions have not been very successful [23,26,27,30]. The effect of topically applied corticosteroid for the treatment of corneal alkali wounds has been controversial [2,11,17,21]. Although the application of corticosteroid on alkali-wounded cornea might enhance corneal melting [1,3,28], the anti-inflammatory action of topical steroid should provide some therapeutic benefit.…”

Section: Introductionmentioning

confidence: 99%

Effect of 0.1% dexamethasone on epithelial healing in experimental corneal alkali wounds: morphological changes during the repair process

Chung¹,

Kang

Kim³

1998

Graefe's Archive for Clinical and Experimental Ophthalmology

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Section: Introductionmentioning

confidence: 99%

Effect of 0.1% dexamethasone on epithelial healing in experimental corneal alkali wounds: morphological changes during the repair process

Chung¹,

Kang

Kim³

1998

Graefe's Archive for Clinical and Experimental Ophthalmology

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“…Hence, the search for new drugs that stabilize the corneal epithelium has been, and still is, intensive. [3][4][5][6][7] Before being approved by federal law for clinical use in humans, candidate drugs are subjected to a series of tests to assess both their impact on wound healing and their toxicity.…”

Section: Introductionmentioning

confidence: 99%

An Ex-Vivo, Whole-Globe Porcine Model of Corneoepithelial Wound Healing Tested Using Immunomodulatory Drugs

Flueckiger

Kodjikian²,

Halberstadt³

et al. 2005

Journal of Ocular Pharmacology and Therapeutics

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Drug screening with this ex vivo porcine model permits a reproducibly quantitative and time- and dose-dependent assessment of corneoepithelial wound healing. This model corresponds more closely to the clinical situation than cell culturing and may, therefore, be useful in evaluating novel pharmaceutical agents, thereby helping to cut down on the number of animal experiments performed prior to the instigation of clinical trials.

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“…Its use is primarily in the treatment of ocular disease. It appears to be active in various eye-related disease models [112] and exhibits activity selectively in the eye but does not raise intraocular pressure.…”

Section: Antedrugs/soft Steroidsmentioning

confidence: 99%

New and improved glucocorticoid receptor ligands

Miner

Hong

Negro‐Vilar

2005

Expert Opinion on Investigational Drugs

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The therapeutic and prophylactic use of glucocorticoids is widespread due to their powerful anti-inflammatory, antiproliferative and immunomodulatory activity. However, long-term use of these drugs can result in severe dose-limiting side effects. One of the most critical and debilitating side effects is osteoporosis, which leads to increased risk of fractures. Glucocorticoids damage bone through several different mechanisms. The search for novel glucocorticoids that have reduced side effects in bone and other tissues is being driven by the identification of new mechanisms of action of the glucocorticoid receptor. This may facilitate the detection of new, safer therapies with efficacies equivalent to currently prescribed steroids.

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Effect of a novel soft steroid on the wound healing of rabbit cornea

Cited by 24 publications

References 18 publications

Effect of 0.1% dexamethasone on epithelial healing in experimental corneal alkali wounds: morphological changes during the repair process

Effect of 0.1% dexamethasone on epithelial healing in experimental corneal alkali wounds: morphological changes during the repair process

An Ex-Vivo, Whole-Globe Porcine Model of Corneoepithelial Wound Healing Tested Using Immunomodulatory Drugs

New and improved glucocorticoid receptor ligands

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