Effect of a novel rice fermented extract on gastric ulcers in horses

Sasaki, Naoki; Nishi, Yasunobu; Fujiwara, Yumi; Takeyama, Tetsuya; Hayata, Kumagai; Senarathna, Samantha; Ushiya, Shigeto; Tokuyama, Takashi; Tokuyama, Takeshi; Tokuyama, Takaaki; Mii, Tomohiro; Ayaki, Satomi; Matsuno, Kosuke; Nakagawa, Yuki; Nishihara, Yoko; Taura, Yasuho

doi:10.1294/jes.32.27

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…A micronized, fermented and pasteurized soy product was evaluated in a population made up of a majority of racehorses, and was protective against increased ESGD scores compared to the pollard control fed for 30 days [ 203 ]. A non-blinded study found that one month’s supplementation with a fermented rice extract significantly improved naturally occurring ESGD scores compared to tap water [ 204 ]. Aloe vera fed at 17.6 mg/kg PO BID for 28 days was found to reduce naturally occurring ESGD scores and heal lesions in 56% of 19 horses in one study without a control group [ 136 ].…”

Section: Preventionmentioning

confidence: 99%

Equine Gastric Ulcer Syndrome: An Update on Current Knowledge

Vokes

Lovett

Sykes

2023

Animals

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Equine Gastric Ulcer Syndrome (EGUS) is a term that has been used since 1999, initially being used to describe all gastric mucosal disease in horses. Since this time, the identification of two distinct main disease entities of the equine gastric mucosa have been described under the umbrella of EGUS; these are Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD). In 2015 the European College of Equine Internal Medicine (ECEIM) released a consensus statement defining these disease entities. This document highlighted the lack of evidence surrounding EGGD compared to ESGD, and identified knowledge gaps for further research to be directed. Subsequently, many studies on EGGD have been published, especially on pathophysiology, diagnosis, and treatment. This article updates current knowledge on both ESGD and EGGD as understanding has evolved since the last large-scale review.

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Section: Preventionmentioning

confidence: 99%

Equine Gastric Ulcer Syndrome: An Update on Current Knowledge

Vokes

Lovett

Sykes

2023

Animals

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“…The NF-κB induces the production of a large number of cytokines and growth factors, which further activates NF-κB, exacerbating the inflammatory response [7]. Inhibiting the NF-κB signaling pathway improves ethanol-induced gastric ulcers in rats [8]. Furthermore, NF-κB activation promotes inflammation and carcinogenesis of gastric mucosal epithelial cells during infection with H. pylori.…”

Section: Introductionmentioning

confidence: 99%

Curculigoside attenuates Helicobacter pylori-induced inflammation and apoptosis of gastric mucosal epithelial cells via NF-κB pathway

Li¹,

Su²

2023

Trop. J. Pharm Res

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Purpose: To investigate the possible effects and mechanisms of action of curculigoside (Cur) on gastric ulcers. Methods: Human gastric mucosal epithelial GES-1 cells were infected with Helicobacter pylori and then treated with Cur. Cell counting kit 8 (CCK-8), flow cytometry, and immunofluorescence assays were used to investigate the effect of Cur on cell viability and apoptosis after exposure to H. pylori. Inflammation status and reactive oxygen species (ROS) were assessed using enzyme-linked immunoassay (ELISA) and dichlorodihydrofluorescein (DCF) staining, respectively, while immunoblot and immunofluorescence assays were performed to determine the effect of Cur on the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Results: Cur significantly increased H. pylori-induced cell viability and inhibited H. pylori-induced inflammatory cytokine production (p < 0.01). Furthermore, Cur significantly suppressed H. pylori-induced ROS production and apoptosis (p < 0.01). Through the NF-κB pathway, Cur attenuated H. pylori-induced inflammation and apoptosis of gastric mucosal epithelial cells. Conclusion: In H. pylori infection, Cur treatment increases cell viability, reduces inflammatory cytokine production, suppresses ROS production, and inhibits apoptosis via NF-κB pathway. Further investigation using whole animal experiments would be needed to establish the role of Cur in the management of H. pylori-induced gastric ulcers.

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Effect of a novel rice fermented extract on gastric ulcers in horses

Cited by 2 publications

References 12 publications

Equine Gastric Ulcer Syndrome: An Update on Current Knowledge

Equine Gastric Ulcer Syndrome: An Update on Current Knowledge

Curculigoside attenuates Helicobacter pylori-induced inflammation and apoptosis of gastric mucosal epithelial cells via NF-κB pathway

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