Effect of a novel glass ionomer cement containing fluoro-zinc-silicate fillers on biofilm formation and dentin ion incorporation

Hasegawa, Taisuke; Takenaka, Shoji; Ohsumi, Tatsuya; Ida, Takako; Ohshima, Hayato; Terao, Yutaka; Naksagoon, Traithawit; Maeda, Takeyasu; Noiri, Yuichiro

doi:10.1007/s00784-019-02991-0

Cited by 22 publications

(29 citation statements)

References 37 publications

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“…Thus, acidity-induced release of Zn 2+ is expected to hinder plaque formation on the surfaces of materials containing BioUnion filler. Hasegawa et al reported that a GIC containing BioUnion filler inhibited S. mutans biofilm formation by interfering with bacterial adhesion on the surface 18) . Saad et al reported the inhibition of root dentin demineralization and S. mutans biofilm formation by a tooth surface coating comprising BioUnion filler 19) .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effects and physical properties of a glass ionomer cement containing BioUnion filler with acidity-induced ability to release zinc ion

et al. 2021

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BioUnion filler is a bioactive glass particle that releases Zn 2+ in an acidic environment. In this study, the ion release, antibacterial, and physical properties of a glass ionomer cement (GIC) incorporating BioUnion filler (CA) were assessed in vitro. The concentration of Zn 2+ released from CA into acetic acid was higher than that released into water and its minimum inhibitory concentrations against six oral bacterial species. Moreover, the concentration of Zn 2+ -release was maintained during all the seven times it was exposed to acetic acid. Compared to a conventional cement and resin composite, CA significantly inhibited the growth of oral bacteria and hindered their adhesion on the material surface. Thus, our study outcomes show that the release of Zn 2+ from CA in the acidic environment does not affect its compressive strength.

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Section: Introductionmentioning

confidence: 99%

Antibacterial effects and physical properties of a glass ionomer cement containing BioUnion filler with acidity-induced ability to release zinc ion

et al. 2021

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“…The challenges mentioned above have laid the foundation for the development of novel approaches to counter biofilms. Many of these new methodologies, currently under research, involve modification of the dental materials by using antibiotics, incorporation of metal oxides [22], nanoparticles [23], and anti-adhesion coatings using hydrophilic polymers [24].…”

Section: Introductionmentioning

confidence: 99%

Bio-Interactive Zwitterionic Dental Biomaterials for Improving Biofilm Resistance: Characteristics and Applications

Mangal

Kwon

Choi

2020

IJMS

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Biofilms are formed on surfaces inside the oral cavity covered by the acquired pellicle and develop into a complex, dynamic, microbial environment. Oral biofilm is a causative factor of dental and periodontal diseases. Accordingly, novel materials that can resist biofilm formation have attracted significant attention. Zwitterionic polymers (ZPs) have unique features that resist protein adhesion and prevent biofilm formation while maintaining biocompatibility. Recent literature has reflected a rapid increase in the application of ZPs as coatings and additives with promising outcomes. In this review, we briefly introduce ZPs and their mechanism of antifouling action, properties of human oral biofilms, and present trends in anti-biofouling, zwitterionic, dental materials. Furthermore, we highlight the existing challenges in the standardization of biofilm research and the future of antifouling, zwitterated, dental materials.

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“…It acts as a desensitizer by inducing chemical occlusion of dentinal tubules and contains a novel functional filler which releases not only ions like calcium or fluorine but also zinc. Zinc is reported to reduce the demineralization of enamel and dentin, and inhibit dentin collagen degradation, plaque growth and biofilm formation (12,13).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield on dentin hypersensitivity: study protocol for a pilot randomized controlled trial

Mizutani¹,

Mae²,

Ohira³

et al. 2020

Preprint

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Background: Dentin hypersensitivity (DH) is a condition characterized by short and sharp pain which will arise in response to tactile, chemical, thermal, evaporative or osmotic stimuli. The painful symptoms cause discomfort to the patients and decrease their quality of life. Recently, a novel zinc-containing desensitizer CAREDYNE Shield is developed. It is a new type of desensitizer which acts as a desensitizer by inducing chemical occlusion of dentinal tubules, and releases zinc ion for root caries prevention. However, the clinical effectiveness of CAREDYNE Shield on DH is still unclear. Therefore, the aim of this study is to evaluate the effectiveness of CAREDYNE Shield on DH by comparing with that of another desensitizer Nanoseal commonly used in Japan.Methods/Design: This study protocol is a two-arm parallel pilot randomized controlled trial. Forty DH patients will be randomly allocated into 2 groups. Participants in the intervention group will be treated with CAREDYNE Shield; participants in the control group will be treated with Nanoseal. Primary outcome is the reduction of pain intensity in response to air stimuli measured with 5-points verbal response scale from baseline to 4 weeks after the intervention and Fisher's exact test will be used for analysis.Discussion: CAREDYNE Shield can be casually applied to subgingival areas and proximal surfaces because it reacts with only tooth substance. Moreover, zinc is reported to reduce the demineralization of enamel and dentin and inhibit biofilm formation, plaque growth and dentin collagen degradation. Therefore, CAREDYNE Shield may be expected to become a novel useful desensitizer which act not only as a desensitizer but also as a root caries inhibitor.

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Effect of a novel glass ionomer cement containing fluoro-zinc-silicate fillers on biofilm formation and dentin ion incorporation

Cited by 22 publications

References 37 publications

Antibacterial effects and physical properties of a glass ionomer cement containing BioUnion filler with acidity-induced ability to release zinc ion

Antibacterial effects and physical properties of a glass ionomer cement containing BioUnion filler with acidity-induced ability to release zinc ion

Bio-Interactive Zwitterionic Dental Biomaterials for Improving Biofilm Resistance: Characteristics and Applications

The efficacy of a novel zinc-containing desensitizer CAREDYNE Shield on dentin hypersensitivity: study protocol for a pilot randomized controlled trial

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