Effect of a Nonsurgical Embryo Transfer Procedure and/or Altrenogest Therapy on Endogenous Progesterone Concentration in Mares

DeLuca, Catherine; McCue, Patrick M.; Patten, M. L.; Squires, E.L.

doi:10.1016/j.jevs.2010.12.002

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…The general preference is to use recipient mares that have ovulations after the donor, meaning that first pregnancy assessments invariably occurred before the onset of cyclical luteolysis which typically begins between days 13 and 15 after ovulation with a reported range of 10-17 days (Perkins et al, 1993;Ginther et al, 2007;Bollwein et al, 2002). Possibly and more importantly, the absence of any difference in CL function between pregnant and non-pregnant mares following ET indicates that the failure to establish pregnancy was not a factor of the induction of luteolysis as a result of cervical dilation during transfer or consequent contamination as has been proposed previously (Handler et al, 2003) which is consistent with findings in a previous survey of a commercial ET programme (DeLuca et al, 2011;Handler et al, 2006).…”

Section: Discussionsupporting

confidence: 87%

Relationship between colour flow Doppler sonographic assessment of corpus luteum activity and progesterone concentrations in mares after embryo transfer

Brogan

Henning

Stout

et al. 2016

Animal Reproduction Science

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Section: Discussionsupporting

confidence: 87%

Relationship between colour flow Doppler sonographic assessment of corpus luteum activity and progesterone concentrations in mares after embryo transfer

Brogan

Henning

Stout

et al. 2016

Animal Reproduction Science

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“…The results can guide the clinician in the decision to discontinue or continue treatment until the fetoplacental unit provides necessary progestogen support to maintain the pregnancy, which occurs at roughly 100-120 days of gestation (Conley and Ball 2019). It should be noted that altrenogest treatment can suppress endogenous production of progesterone and may interfere with the formation of secondary CL (Daels et al 1992;DeLuca et al 2011). Willmann et al (2011b found altrenogest supplementation to decrease the production of equine chorionic gonadotropin (eCG) in mares greater than 8 years of age.…”

Section: Early Pregnancymentioning

confidence: 99%

The use of progestins in equine medicine: A review

Fedorka

Troedsson

2020

Equine Veterinary Education

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Progesterone is in constant fluctuation throughout the lifespan of the horse. As a key regulator of the hypothalamicpituitary-gonadal axis, progesterone is involved in numerous aspects of reproduction. Synthetic analogs of progesterone, deemed progestins, are widely available to industry to act as progestogenic within the reproductive tract, although few are bioactive in the horse. Utilised to suppress oestrous, delay ovulation, maintain pregnancy, and for behavioural modifications, progestins are a commonly administered class of pharmaceuticals in veterinary medicine. In this review, we discuss the progestins available to equine industry, in addition to assessing efficacy, pharmacokinetics, and potential side effects following administration of each.

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“… which showed convincingly that a lack of progesterone is not a significant cause of early pregnancy loss in the mare. It also disregards studies showing that the administration of altrenogest downregulates and suppresses endogenous progesterone production by the mare's own primary corpus luteum and pregnancy loss can occur in mares being administered altrenogest regardless of the elevated levels of the synthetic progestagen in their blood .…”

Section: Progestagensmentioning

confidence: 99%

Half a century of equine reproduction research and application: A veterinarytour de force

Allen

Wilsher

2017

Equine Veterinary Journal

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SummaryOver the past 50 years, per season pregnancy rate in Thoroughbred mares have risen from 70 to >90% and foaling rates from 55 to >80%. Some of the significant pharmacological treatments and diagnostic methods which have driven this marked improvement in breeding efficiency are reviewed. They include the application of artificial lighting to hasten the onset of ovulatory oestrous cyclicity in early Spring, rapid steroid hormone assays to aid in determining the stage and normality of the mare's cycle, prostaglandin analogues, synthetic progestagens and Gonadotrophin-releasing Hormone (GnRH) analogues to better control and manipulate her cycle to good effect, transrectal ultrasound scanning to monitor follicle growth, endometrial architecture and ovulation and to allow accurate, early pregnancy diagnosis thereby enabling successful ablation of one of twin conceptuses. Also, flexible videoendoscopy to monitor physiological and pathological changes in the uterine endometrium and rigid laparoscopy to apply prostaglandin to the oviducts to dislodge and clear suspected blockages of them to restore fertility. The outbreak of Contagious Equine Metritis in Newmarket in the spring of 1977 and the swabbing-related changes to mare and stallion management, plus the improved veterinary hygiene methods, which followed are also recounted. The past half century has witnessed many technical and therapeutic advances that have enhanced tremendously the diagnostic and treatment capabilities of studfarm veterinary surgeons. They, in turn, have improved greatly the efficiency of breeding Thoroughbreds and other types of horses.

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Effect of a Nonsurgical Embryo Transfer Procedure and/or Altrenogest Therapy on Endogenous Progesterone Concentration in Mares

Cited by 8 publications

References 10 publications

Relationship between colour flow Doppler sonographic assessment of corpus luteum activity and progesterone concentrations in mares after embryo transfer

Relationship between colour flow Doppler sonographic assessment of corpus luteum activity and progesterone concentrations in mares after embryo transfer

The use of progestins in equine medicine: A review

Half a century of equine reproduction research and application: A veterinarytour de force

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