Effect of a new herbal composition comprised of red clover and hop extract on human endothelial cell damage and vasorelaxant activity

Jeon, Se Yeong; Kim, Mi Ran; Lee, Eun Ok; Jeon, Byeong Hwa; Lee, Su Hwan; Lee, Young Chul

doi:10.1111/jfbc.13314

Cited by 5 publications

(7 citation statements)

References 42 publications

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“…More research is required to validate and draw conclusions regarding these potential effects. Our results are in contrast with recent findings in human endothelial cells, which demonstrated that red clover elicits increased eNOS expression, enhanced NO production, and lowered reactive oxygen species production ( 59 ). Although we did not observe a statistically significant increase in eNOS or PGI 2 S protein expression, it is possible that RC supplementation improved the activity of these enzymes and thereby, contributed to the observed reduction in vascular inflammation in this study ( 24 , 60 ).…”

Section: Discussioncontrasting

confidence: 99%

Short-Term Supplementation With Fermented Red Clover Extract Reduces Vascular Inflammation in Early Post-menopausal Women

Wickham

Nørregaard

Oxfeldt

et al. 2022

Front. Cardiovasc. Med.

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The decline in estrogen at menopause poses a critical challenge to cardiovascular and metabolic health. Recently, a growing interest in the role of phytoestrogens, with a particular focus on isoflavones, has emerged as they can bind to estrogen receptors and may mimic the roles of endogenous estrogen. Fermented red clover extract (RC) contains isoflavones with superior bioavailability compared to non-fermented isoflavones, however little is known regarding the impact of isoflavones on cardiovascular and metabolic health. We assessed markers of vascular health in plasma and skeletal muscle samples obtained from healthy but sedentary early post-menopausal women (n = 10; 54 ± 4 years) following 2 weeks of twice daily treatment with placebo (PLA) or RC (60 mg isoflavones per day). The two interventions were administered using a randomized, double-blind, crossover design with a two-week washout period. Plasma samples were utilized for assessment of markers of vascular inflammation. There was a statistically significant reduction (~5.4%) in vascular cell adhesion molecule 1 (VCAM-1) following 2 weeks of RC supplementation compared to PLA (p = 0.03). In contrast, there was no effect of RC supplementation compared to PLA on skeletal muscle estrogen receptor content and enzymes related to vascular function, and angiogenesis. Supplementation with RC reduces vascular inflammation in early post-menopausal women and future studies should address the long-term impact of daily supplementation with RC after menopause.

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Section: Discussioncontrasting

confidence: 99%

Short-Term Supplementation With Fermented Red Clover Extract Reduces Vascular Inflammation in Early Post-menopausal Women

Wickham

Nørregaard

Oxfeldt

et al. 2022

Front. Cardiovasc. Med.

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“…7 While, in 2020, Jeon SY et al investigated the vascular property of a combination of red clover and hop extract (RHEC), demonstrating its capability to evoke vasorelaxation of rat aortic rings, suggesting once again the involvement of NO in its mechanism of action. 36 To the best of our knowledge, the direct vascular effectiveness hop extract on resistance arteries has not been reported yet. Moreover, to date, the data available in the literature have focused the attention only on the polyphenolic extracts of Hop, neglecting the beneficial potential that lies in the α and β acids.…”

Section: Discussionmentioning

confidence: 96%

“…investigated the vascular property of a combination of red clover and hop extract (RHEC), demonstrating its capability to evoke vasorelaxation of rat aortic rings, suggesting once again the involvement of NO in its mechanism of action. 36…”

Section: Discussionmentioning

confidence: 99%

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α acid fraction from Hop extract exerts an endothelium-derived hyperpolarization vasorelaxant effect through TRPV4 employing the feedforward mechanism of PKCα

Di Pietro,

Salviati,

Damato

et al. 2024

Food Funct.

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“…Phytochemicals (e.g. in virgin olive oil, red clover and hop extracts) improving the nitric oxide release demonstrate potential to increase vasodilatation mitigating thereby the endothelial dysfunction related to high ET-1 [59,60]. Further, the anti-inflammatory and cardioprotective properties of curcumin (a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa) are evidently linked to the Ca 2+ /NFATc1-regulated release of ET-1.…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Pre-pregnancy check-up of maternal vascular status and associated phenotype is crucial for the health of mother and offspring

et al. 2022

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Cardiovascular disease remains the leading cause of disease burden globally with far-reaching consequences including enormous socio-economic burden to healthcare and society at large. Cardiovascular health is decisive for reproductive function, healthy pregnancy and postpartum. During pregnancy, maternal cardiovascular system is exposed to highly increased haemodynamic stress that significantly impacts health status of the mother and offspring. Resulting from sub-optimal maternal health conditions overlooked in pre-pregnancy time, progressive abnormalities can be expected during pregnancy and postpartum. Contextually, there are two main concepts to follow in the framework of predictive, preventive and personalised medicine, namely to develop: 1. advanced screening of sub-optimal health conditions in young populations to predict and prevent individual health risks prior to planned pregnancies 2. in-depth companion diagnostics during pregnancy to predict and prevent long-lasting postpartum health risks of the mother and offspring. Data collected in the current study demonstrate group-specific complications to health of the mother and offspring and clinical relevance of the related phenotyping in pre-pregnant mothers. Diagnostic approach proposed in this study revealed its great clinical utility demonstrating important synergies between cardiovascular maladaptation and connective tissue dysfunction. Co-diagnosed pre-pregnancy low BMI of the mother, connective tissue dysfunction, increased stiffness of peripheral vessels and decreased blood pressure are considered a highly specific maternal phenotype useful for innovative screening programmes in young populations to predict and prevent severe risks to health of the mother and offspring. This crucial discovery brings together systemic effects characteristic, for example, for individuals with Flammer syndrome predisposed to the phenotype-specific primary vascular dysregulation, pregnancy-associated risks, normal tension glaucoma, ischemic stroke at young age, impaired wound healing and associated disorders. Proposed maternal phenotyping is crucial to predict and effectively protect both the mother and offspring against health-to-disease transition. Pre-pregnancy check-up focused on sub-optimal health and utilising here described phenotypes is pivotal for advanced health policy. Plain English abstract Cardiovascular health is decisive for reproductive function and healthy pregnancy. During pregnancy, maternal cardiovascular system may demonstrate health-to-disease transition relevant for the affected mother and offspring. Overlooked in pre-pregnancy time, progressive abnormalities can be expected during pregnancy and lifelong. Here we co-diagnosed maternal pre-pregnancy low bodyweight with systemic effects which may increase risks of pregnancy, eye and heart disorders and ischemic stroke at young age, amongst others. Innovative screening programmes focused on sub-optimal health in young populations to predict and to mitigate individual health risks prior to pregnancy is an essential innovation for health policy proposed.

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Effect of a new herbal composition comprised of red clover and hop extract on human endothelial cell damage and vasorelaxant activity

Cited by 5 publications

References 42 publications

Short-Term Supplementation With Fermented Red Clover Extract Reduces Vascular Inflammation in Early Post-menopausal Women

Short-Term Supplementation With Fermented Red Clover Extract Reduces Vascular Inflammation in Early Post-menopausal Women

α acid fraction from Hop extract exerts an endothelium-derived hyperpolarization vasorelaxant effect through TRPV4 employing the feedforward mechanism of PKCα

Pre-pregnancy check-up of maternal vascular status and associated phenotype is crucial for the health of mother and offspring

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