Effect of a major QTL affecting IPN resistance on production traits in Atlantic salmon

Gheyas, Almas; Haley, Chris; Guy, D. R.; Hamilton, Alastair; Tinch, A. E.; Mota-Velasco, J. C.; Woolliams, John

doi:10.1111/j.1365-2052.2010.02051.x

Cited by 19 publications

(10 citation statements)

References 8 publications

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“…Given the variability in survival levels we found among F 1 and BC 1 families in both genetic backgrounds (crosses of “S” to “Y” or “D”), and given the strong heritable component we found for this trait, our previous and current findings suggested that CyHV-3 resistance is a multigenic trait. Several examples exist where disease resistance seems to be conditioned by a single or major gene (Fuji et al, 2006; Moen et al, 2009; Gheyas et al, 2010; Houston et al, 2010; Baerwald et al, 2011; Verrier et al, 2013). On one hand, traditional and marker-assisted breeding to improve disease resistance might be straighter forward when most trait variability is explained by a single locus.…”

Section: Discussionmentioning

confidence: 99%

Studying the Genetics of Resistance to CyHV-3 Disease Using Introgression from Feral to Cultured Common Carp Strains

et al. 2017

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Sustainability and further development of aquaculture production are constantly challenged by outbreaks of fish diseases, which are difficult to prevent or control. Developing fish strains that are genetically resistant to a disease is a cost-effective and a sustainable solution to address this challenge. To do so, heritable genetic variation in disease resistance should be identified and combined together with other desirable production traits. Aquaculture of common carp has suffered substantial losses from the infectious disease caused by the cyprinid herpes virus type 3 (CyHV-3) virus and the global spread of outbreaks indicates that many cultured strains are susceptible. In this research, CyHV-3 resistance from the feral strain “Amur Sassan” was successfully introgressed into two susceptible cultured strains up to the first backcross (BC1) generation. Variation in resistance of families from F1 and BC1 generations was significantly greater compared to that among families of any of the susceptible parental lines, a good starting point for a family selection program. Considerable additive genetic variation was found for CyHV-3 resistance. This phenotype was transferable between generations with contributions to resistance from both the resistant feral and the susceptible cultured strains. Reduced scale coverage (mirror phenotype) is desirable and common in cultured strains, but so far, cultured mirror carp strains were found to be susceptible. Here, using BC1 families ranging from susceptible to resistant, no differences in resistance levels between fully scaled and mirror full-sib groups were found, indicating that CyHV-3 resistance was successfully combined with the desirable mirror phenotype. In addition, the CyHV-3 viral load in tissues throughout the infection of susceptible and resistant fish was followed. Although resistant fish get infected, viral loads in tissues of these fish are significantly lesser than in those of susceptible fish, allowing them to survive the disease. Taken together, in this study we have laid the foundation for breeding CyHV-3-resistant strains and started to address the mechanisms underlying the phenotypic differences in resistance to this disease.

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Section: Discussionmentioning

confidence: 99%

Studying the Genetics of Resistance to CyHV-3 Disease Using Introgression from Feral to Cultured Common Carp Strains

et al. 2017

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“…Several authors have reported QTLs for IPNV, and most show that the anti-IPNV loci are located on LG21 [37][38][39][40], indicating that rainbow trout and Atlantic salmon anti-IPNV QTLs may be evolutionarily conserved. The genetic effects of Atlantic salmon anti-IHN QTLs have been validated in other studies [41]. Fuji et al [42] used a segregated population and located a single major QTL controlling resistance to lymphocystis disease on LG15 in Japanese flounder with a phenotypic variation value of 50%.…”

Section: Qtl For Disease Resistancementioning

confidence: 96%

Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish

Tong

Sun

2015

Sci. China Life Sci.

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The traits of cultured fish must continually be genetically improved to supply high-quality animal protein for human consumption. Economically important fish traits are controlled by multiple gene quantitative trait loci (QTL), most of which have minor effects, but a few genes may have major effects useful for molecular breeding. In this review, we chose relevant studies on some of the most intensively cultured fish and concisely summarize progress on identifying and verifying QTLs for such traits as growth, disease and stress resistance and sex in recent decades. The potential applications of these major-effect genes and their associated markers in marker-assisted selection and molecular breeding, as well as future research directions are also discussed. These genetic and genomic analyses will be valuable for elucidating the mechanisms modulating economically important traits and to establish more effective molecular breeding techniques in fish.aquaculture fish, economic traits, QTL, major genes, molecular markers, molecular breeding Citation:Tong JG, Sun XW. Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish. Sci

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“…And as such, diferent approaches such as SNP, MTLS, AFLP, RAPD, RFLP and QTL analyses have been used for the identiication of disease resistance and susceptibility traits in diferent aquatic organisms. In the case of ish viral diseases, QTL resistance traits have been generated for grass cap reovirus (GCRV) infection in grass carp [179], nervous necrosis virus (NNV) in seabass [180], viral hemorrhagic septicemia (VHS) in turbot [181] and rainbow trout [182], infectious salmon anaemia (ISAV) virus in Atlantic salmon, lymphocytic disease virus in Japanese lounder [183] and infectious pancreatic necrosis virus (IPNV) in Atlantic salmon [184,185]. Among these, the QTL for resistance against IPNV has contributed to signiicantly reducing the IPNV incidence by >80% from 2008 when IPNV resistance ish were introduced in the Norwegian Atlantic salmon industry to 2015 [186].…”

Section: Applications Of Rna-seq and Omics Strategies -From Microorgamentioning

confidence: 99%

Current Advances in Functional Genomics in Aquaculture

Munang’andu¹,

Evensen²

2017

Applications of RNA-Seq and Omics Strategies - From Microorganisms to Human Health

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Gene expression studies in aquaculture have slowly evolved from the traditional reductionist approach of single gene sequencing to high throughput sequencing (HTS) techniques able to sequence entire genomes of living organisms. The upcoming of HTS techniques has led to emergence of metagenomics, nutrigenomics, epigenetics and other omics technologies in aquaculture in the last decade. Metagenomics analyses have accelerated the speed at which emerging pathogens are being discovered, thereby contributing to the design of timely disease control strategies in aquaculture. Using metagenomics, it is easy to identify and monitor microbial communities found in diferent ecosystems. In vaccine production, genomic studies are being used to identify cross neutralizing antigens against variant strains of the same pathogens. In genetics and epigenetics, genomics traits have been identiied that are beginning to gain commercial applications in aquaculture. Nutrigenomics have not only enhanced our understanding of the biological markers for nutrition-related diseases, but they have also enhanced our ability to formulate diets able to maintain a stable immune homeostasis in the gut. Overall, herein, we have shown that functional genomics provide multifaceted applications ranging from monitoring microbial communities in aquatic environments to optimizing production systems in aquaculture.

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Effect of a major QTL affecting IPN resistance on production traits in Atlantic salmon

Cited by 19 publications

References 8 publications

Studying the Genetics of Resistance to CyHV-3 Disease Using Introgression from Feral to Cultured Common Carp Strains

Studying the Genetics of Resistance to CyHV-3 Disease Using Introgression from Feral to Cultured Common Carp Strains

Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish

Current Advances in Functional Genomics in Aquaculture

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