Effect of a magnetic field on the track structure of low-energy electrons: a Monte Carlo study

Bug, Marion U.; Gargioni, E.; Guatelli, Susanna; Incerti, S.; Rabus, Hans; Schulte, R.; Rosenfeld, Anatoly B.

doi:10.1140/epjd/e2010-00145-1

Cited by 37 publications

(48 citation statements)

References 31 publications

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“…Bug et al, [117] and Lazarakis et al [72] studied the effect of the magnetic field on the track structure of electrons, protons and alpha particles on the cluster size distribution in a DNA segment, modelled as a liquid water cylinder with nanometric sizes. The intensity of the magnetic field was varied from 0 to 14 T. The Geant4-DNA Package was adopted to model the physics interactions of particles in the set-up.…”

Section: Geant4-dna Coupled With Tracking In Magnetic Fieldsmentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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Section: Geant4-dna Coupled With Tracking In Magnetic Fieldsmentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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“…A variety of applications based on GEANT4-DNA processes and models allow the study of elementary energy deposition patterns at the sub-cellular scale. For example, the comparison of dose point kernels [114], S-values [115], radial doses [116], cluster patterns for ions with the same LET [117], the effect of a magnetic field on electron track structures [118], and the modeling of direct DNA damage [119][120][121][122] have so far been explored utilizing these tools. They even provide a framework for the future study of non-targeted biological effects [123], extending further the first applications of GEANT4 electromagnetic physics at the physics-biology frontier [124][125][126][127][128][129][130].…”

Section: Geant4-dna Physics Modelsmentioning

confidence: 99%

Recent Developments in Geant4

2014

SNA + MC 2013 - Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo

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During the last two to three years extensive development of the Geant4 simulation toolkit has occurred, which will culminate in a major release at the end of 2013. This development includes the adoption of multi-threading, the extension and improvement of physics models, improvements to the geometry modeler with a revised implementation of most geometrical primitives, advances in visualization and graphical user interfaces (GUI), the move from GNU make to CMake and the extension and automation of the Geant4 testing suite. The reasons for and implementation of multi-threading will be discussed. Certain electromagnetic and hadronic model extensions will also be discussed along with their effects on calorimeter results. Finally, visualization and GUI improvements will be highlighted along with the new configuration, build and testing systems.

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“…The Geant4 Very Low Energy Package [45,46] models particle interactions in water, the main substance of biological systems, down to the electronvolt scale. This physics component is of particular interest for nanodosimetric studies as [13].…”

Section: Electromagnetic Physics Interactionsmentioning

confidence: 99%

“…Geant4 is also used to study possible novel radiotherapy treatments. For example, [13] describes the possibility to enhance the effectiveness of radiotherapy, thanks to the introduction of a magnetic field in the treatment region. At CMRP Geant4 is widely used also for protontherapy related studies as the one described in [14].…”

Section: Introduction To the Geant4 Simulation Toolkit Introductionmentioning

confidence: 99%

Introduction to the Geant4 Simulation toolkit

Guatelli¹,

Cutajar²,

Oborn³

et al. 2011

AIP Conference Proceedings

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Abstract. Geant4 is a Monte Carlo simulation Toolkit, describing the interactions of particles with matter. Geant4 is widely used in radiation physics research, from High Energy Physics, to medical physics and space science, thanks to its sophisticated physics component, coupled with advanced functionality in geometry description. Geant4 is widely used at the Centre for Medical Radiation Physics (CMRP), at the University of Wollongong, to characterise and optimise novel detector concepts, radiotherapy treatments, and imaging solutions. This lecture consists of an introduction to Monte Carlo method, and to Geant4. Particular attention will be devoted to the Geant4 physics component, and to the physics models describing electromagnetic and hadronic physics interactions. The second part of the lecture will be focused on the methodology to adopt to develop a Geant4 simulation application.

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Effect of a magnetic field on the track structure of low-energy electrons: a Monte Carlo study

Cited by 37 publications

References 31 publications

Review of Geant4-DNA applications for micro and nanoscale simulations

Review of Geant4-DNA applications for micro and nanoscale simulations

Recent Developments in Geant4

Introduction to the Geant4 Simulation toolkit

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