Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial

Misciagna, Giovanni; Díaz, Margarita; Caramia, D. V.; Bonfiglio, Caterina; Franco, Isabella; Noviello, M. R.; Chiloiro, Marisa; Abbrescia, Daniela Isabel; Mirizzi, Antonella; Tanzi, Matthew V; Caruso, Mariangela; Correale, M.; Reddavide, Rosa; Inguaggiato, Rosa; Cisternino, Anna Maria; Osella, Alberto Rubén

doi:10.1007/s12603-016-0809-8

Cited by 104 publications

(110 citation statements)

References 51 publications

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“…Fruit and vegetable intake is associated with higher dietary vitamin E and D, with vitamin E influencing lower levels of liver steatosis and inflammation and vitamin D decreasing inflammation and increasing glucose and lipid metabolism. The inverse association between the Mediterranean diet and NAFLD reported by prior studies and with HCC incidence in the MEC Latinos in the current study is important to note given the high prevalence of NAFLD in Latinos and the large fraction of NALFD‐associated HCC among Latinos …”

Section: Discussionsupporting

confidence: 55%

High‐Quality Diets Are Associated With Reduced Risk of Hepatocellular Carcinoma and Chronic Liver Disease: The Multiethnic Cohort

et al. 2019

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Hepatocellular carcinoma (HCC) and chronic liver disease (CLD) are major sources of morbidity and mortality globally. Both HCC incidence and CLD mortality are known to vary by race. There is limited research on the association between dietary measures and these outcomes in a diverse population. We prospectively investigated the associations between four diet quality index (DQI) scores (Healthy Eating Index‐2010, Alternative Healthy Eating Index‐2010, Alternate Mediterranean Diet [aMED], and Dietary Approaches to Stop Hypertension), HCC incidence, and CLD mortality in the Multiethnic Cohort. We analyzed data from 169,806 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites, aged 45 to 75 years. DQI scores were calculated by using a validated food frequency questionnaire administered at baseline. During an average 17 years of follow‐up, 603 incident cases of HCC and 753 CLD deaths were identified among study participants. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for each DQI were estimated using Cox regression. Higher aMED scores, reflecting favorable adherence to a healthful diet, were associated with a lower risk of HCC (quintile [Q]5 versus Q1 HR, 0.68; 95% CI, 0.51‐0.90; trend, P = 0.02). In racial/ethnic‐specific analyses, there was no significant heterogeneity across groups (interaction, P = 0.32); however, the association only remained statistically significant among Latinos (Q4 versus Q1 HR, 0.47; 95% CI, 0.29‐0.79; trend, P = 0.006). All DQI measures were inversely associated with CLD mortality, with no significant heterogeneity by race/ethnicity. Conclusion: Higher aMED scores were associated with a lower risk of HCC. A higher score of any DQI was associated with a lower risk of CLD mortality. These results suggest that better diet quality may reduce HCC incidence and CLD mortality.

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Section: Discussionsupporting

confidence: 55%

High‐Quality Diets Are Associated With Reduced Risk of Hepatocellular Carcinoma and Chronic Liver Disease: The Multiethnic Cohort

et al. 2019

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“…Lastly, we did not assess non-alcoholic fatty liver disease (NAFLD), which plays a central role in obesityrelated diseases, because methods to measure NAFLD were not available. In a previous study (44) , dietary intervention such as a low glycaemic index Mediterranean diet was recommended for reducing the severity of NAFLD and preventing T2DM and cardiovascular disease. Further studies concerning the association between carbohydrate quality and NAFLD in Korean subjects are needed.…”

Section: Discussionmentioning

confidence: 99%

Association between dietary carbohydrate quality and the prevalence of obesity and hypertension

Kim

Lim

2018

J Human Nutrition Diet

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“…Although several dietary approaches could be used for the treatment of NAFLD [74], over the past several years, the Mediterranean one has attracted special interest. Cross-sectional and longitudinal reports evidenced a lower likelihood of NASH in patients who were adherent to the MedDiet [75,76], whereas randomized controlled crossover trials defined the superiority of this diet in the improvement of insulin sensitivity, metabolic parameters and steatosis over low-fat ones [77,78]. Furthermore, a 6-month nutritional counseling to adhere to the MedDiet has proved to be effective in the amelioration of certain disease-specific traits, including liver imaging, liver fibrosis score, inflammatory/oxidative biomarkers and glycemic status indices in non-fibrotic NAFLD patients [79].…”

Section: Meddiet and Extra-virgin Olive Oil (Evoo)-derived Secoiridoimentioning

confidence: 99%

Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases

et al. 2020

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Insulin resistance (IR), defined as an attenuated biological response to circulating insulin, is a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide spectrum of pathological conditions, such as non-alcoholic fatty liver disease (NAFLD), cognitive impairment, endothelial dysfunction, chronic kidney disease (CKD), polycystic ovary syndrome (PCOS), and some endocrine tumors, including breast cancer. In obesity, the unbalanced production of pro- and anti-inflammatory adipocytokines can lead to the development of IR and its related metabolic complications, which are potentially reversible through weight-loss programs. The Mediterranean diet (MedDiet), characterized by high consumption of extra-virgin olive oil (EVOO), nuts, red wine, vegetables and other polyphenol-rich elements, has proved to be associated with greater improvement of IR in obese individuals, when compared to other nutritional interventions. Also, recent studies in either experimental animal models or in humans, have shown encouraging results for insulin-sensitizing nutritional supplements derived from MedDiet food sources in the modulation of pathognomonic traits of certain IR-related conditions, including polyunsaturated fatty acids from olive oil and seeds, anthocyanins from purple vegetables and fruits, resveratrol from grapes, and the EVOO-derived, oleacein. Although the pharmacological properties and clinical uses of these functional nutrients are still under investigation, the molecular mechanism(s) underlying the metabolic benefits appear to be compound-specific and, in some cases, point to a role in gene expression through an involvement of the nuclear high-mobility group A1 (HMGA1) protein.

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Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial

Cited by 104 publications

References 51 publications

High‐Quality Diets Are Associated With Reduced Risk of Hepatocellular Carcinoma and Chronic Liver Disease: The Multiethnic Cohort

High‐Quality Diets Are Associated With Reduced Risk of Hepatocellular Carcinoma and Chronic Liver Disease: The Multiethnic Cohort

Association between dietary carbohydrate quality and the prevalence of obesity and hypertension

Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases

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