Effect of a lignan (HPMF) on RNA synthesis in the rat uterus

Waters, Andrew P.; Knowler, John T.

doi:10.1530/jrf.0.0660379

Cited by 58 publications

(15 citation statements)

References 7 publications

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“…Both weak estrogenic [32] and antiestrogenic [33] properties have been reported for lignans and isoflavonoids; they are also inhibitors of aromatase [34] and 5␣-reductase [35] and stimulate sex hormone binding globulin synthesis in the liver [36]. In addition, soya and flaxseed inhibit tumorigenesis in experimental animals [37,38].…”

Section: Discussionmentioning

confidence: 99%

Lignans and isoflavonoids in plasma and prostatic fluid in men: Samples from Portugal, Hong Kong, and the United Kingdom

Morton¹,

Chan²,

Chen³

et al. 1997

Prostate

210

130

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Section: Discussionmentioning

confidence: 99%

Lignans and isoflavonoids in plasma and prostatic fluid in men: Samples from Portugal, Hong Kong, and the United Kingdom

Morton¹,

Chan²,

Chen³

et al. 1997

Prostate

210

130

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“…No antiestrogenic properties could be observed (36). In another study enterolactone in vivo inhibited estrogen-stimulated RNA synthesis in rat uterine tissue when administered 22 hr before estradiol (37). The concentrations of enterolactone were very low, and it is doubtful whether this result can be repeated.…”

Section: Biological Effects Of Lignans and Isoflavonoidsmentioning

confidence: 99%

Phytoestrogens: Epidemiology and a Possible Role in Cancer Protection

Adlercreutz¹

1995

Environmental Health Perspectives

130

110

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Because many diseases of the Western Hemisphere are hormone-dependent cancers, we have postulated that the Western diet, compared to a vegetarian or semivegetarian diet, may alter hormone production, metabolism, or action at the cellular level by some biochemical mechanisms. Recently, our interest has been mainly focused on the cancer-protective role of some hormonelike diphenolic phytoestrogens of dietary origin, the lignans and the isoflavonoids. The precursors of the biologically active compounds originate in soybean products (mainly isoflavonoids), whole grain cereal food, seeds, and probably berries and nuts (mainly lignans). The plant lignan and isoflavonoid glycosides are converted by intestinal bacteria to hormonelike compounds with weak estrogenic but also antioxidative activity; they have now been shown to influence not only sex hormone metabolism and biological activity but also intracellular enzymes, protein synthesis, growth factor action, malignant cell proliferation, differentiation, and angiogenesis in a way that makes them strong candidates for a role as natural cancer-protective compounds. Epidemiologic investigations strongly support this hypothesis because the highest levels of these compounds in the diet are found in countries or regions with low cancer incidence. This report is a review on recent results suggesting that the diphenolic isoflavonoids and lignans are natural cancer-protective compounds. -Environ Health Perspect 103(Suppl 7):103-1 12 (1995)

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“…It is hypothesized that consumption of foods high in lignan and isoflavonoid precursors may decrease the risk of hormone-dependent (3,4) and other (11,12) cancers. These compounds have 2-phenylnaphthalene-type structures similar to estrogens (13), exhibit weak estrogenic (14)(15)(16) and antiestrogenic activity (14,17,18), and have been found to bind to the estrogen receptor and the nuclear type II estrogen-binding sites (3,19,20). Other mechanisms whereby these compounds may exert chemopreventive effects include weak antioxidant activity (12,21); inhibition of tumor cell growth (3,(22)(23)(24); inhibition of angiogenesis (25); and inhibition of protein tyrosine kinase (26)(27)(28), topoisomerase II (29,30), and protein histidine kinase (31) activity.…”

Section: Urinary Lignan and Isoflavonoid Excretion In Men And Women Cmentioning

confidence: 99%

Urinary Lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets

Kirkman

Lampe

Campbell

et al. 1995

Nutrition and Cancer

106

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Urinary lignan and isoflavonoid excretion were examined in 11 men and 9 women consuming four nine-day controlled experimental diets: basal (vegetable free), carotenoid vegetable (carrot and spinach), cruciferous vegetable (broccoli and cauliflower), and soy (tofu and textured vegetable protein product). Three-day urine collections (Days 7-9) were analyzed for lignans and isoflavonoids with use of isotope-dilution gas chromatography-mass spectrometry. Urinary excretion of the lignans enterodiol and enterolactone was higher during the carotenoid and cruciferous vegetable diets than during the basal diet (p = 0.0001), suggesting that these vegetables may provide a source of mammalian lignan precursors. Urinary excretion of the isoflavonoids equol, O-desmethylangolensin, daidzein, and genistein was higher when subjects consumed soy diets than when they consumed the other test diets (p < 0.02). Gender differences in lignan excretion were observed. Men excreted more enterolactone (p = 0.006) and less enterodiol (p = 0.013) than women, implying a gender difference in colonic bacterial metabolism of lignans. There was no effect of gender on isoflavonoid excretion.

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Effect of a lignan (HPMF) on RNA synthesis in the rat uterus

Abstract: HPMF, at doses of 0\m=.\01\p=n-\1 mg/kg, had no effect on uterine RNA synthesis over a period of 24 h. It significantly depressed oestrogen-stimulated RNA synthesis if administered 22 h before oestradiol but not if given 10 h before or together with the hormone.

Cited by 58 publications

References 7 publications

Lignans and isoflavonoids in plasma and prostatic fluid in men: Samples from Portugal, Hong Kong, and the United Kingdom

Lignans and isoflavonoids in plasma and prostatic fluid in men: Samples from Portugal, Hong Kong, and the United Kingdom

Phytoestrogens: Epidemiology and a Possible Role in Cancer Protection

Urinary Lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets

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