1986
DOI: 10.1016/s0006-291x(86)80454-5
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Effect of a interleukin-I like factor (mononuclear cell factor) on proteoglycan synthesis in cultured human articular chondrocytes

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Cited by 26 publications
(12 citation statements)
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“…However, IL-1 increased DNA synthesis or proteoglycan synthesis in other culture systems (45,46). On the other hand, IL-l consistently suppressed ALPase activity and mineralization in various culture systems with different batches ofrabbit and porcine chondrocytes (data not shown).…”
Section: Discussionmentioning
confidence: 87%
“…However, IL-1 increased DNA synthesis or proteoglycan synthesis in other culture systems (45,46). On the other hand, IL-l consistently suppressed ALPase activity and mineralization in various culture systems with different batches ofrabbit and porcine chondrocytes (data not shown).…”
Section: Discussionmentioning
confidence: 87%
“…(17) The present study investigated the effects of strontium ranelate on stromelysin and PG synthesis in human chondrocytes cultured with or without IL-1␤ or IGF-I. In chondrocyte culture, IL-1␤ reproduces the decoupling effect leading to a decrease in PG and an increase in stromelysin synthesis, (4,18) whereas IGF-I stimulates PG production.…”
Section: Introductionmentioning
confidence: 95%
“…In contrast, indomethacin was shown to suppress glycosaminoglycan synthesis [42]. Besides, it is worth noting that in chondrocyte cultures aspirin has no effect on proteoglycan production [43] but on the other hand, indomethacin inhibits this synthesis [44,45]. As chondrocyte monolayer cultures were proved to be relevant for studying the action of many non steroidal anti-inflammatory drugs on proteoglycan synthesis, this model was thought to be a good approach for estimating the direct action of D-Pen (which is accepted as a disease modifying antirheumatic drug) on cartilage proteoglycans.…”
Section: Discussionmentioning
confidence: 99%
“…According to calibration curves recently published [57], the molecular weight of these proteoglycans can be estimated aproximatively 300 kD. Monomeric proteoglycans extracted from articular cartilage [58] or chondrocyte cultures [45] are generally eluted with an approximate Kav= 0.3 (Sepharose CL-2B) corresponding to a molecular weight of about 1 to 2.5 • 10 6 daltons [59]. Nevertheless, such proteoglycans with a low molecular weight have already been identified in chondrocyte cultures [60][61][62].…”
Section: Discussionmentioning
confidence: 99%