Effect of a Hygiene Protocol on Denture-Related Stomatitis Remission, Local Inflammatory Factors, and Hemodynamic Responses by Arterial Pressure

Abstract

Denture-related stomatitis (DRS) is frequent oral inflammation in complete denture wearers. This study evaluated the effect of a hygiene protocol on DRS remission, local inflammatory factors, and hemodynamic responses. Thirty-three individuals were enrolled in the study. The outcomes were measured before and after 10 days of a hygiene protocol treatment consisting of brushing the palate with a soft brush and water and denture brushing with a denture-specific brush and mild soap, as well as immersion of the denture for 20 min in a 0.25% sodium hypochlorite solution. Data were analyzed by paired Wilcoxon for biofilm removal and CFU count of microorganisms. The paired T test was used to assess salivary MUC 1, cytokines, and arterial pressure (p < 0.05). A significant difference was found in the DRS degree (p < 0.001), biofilm (p < 0.001), microbial load of Candida spp. (p < 0.001), Gram-negative (p < 0.004), Staphylococcus spp. (p < 0.001), and S. mutans (p < 0.001) of the denture, and S. mutans (p < 0.001) of the palate after use of the protocol. The salivary flow (p = 0.2) and pH (p = 0.97) did not change; there was an increase of MUC 1 (p = 0.049) and a decrease in IL-6 (p = 0.038), IL-2 (p = 0.04), IL-10 (p = 0.041), and IFNγ (p = 0.04). There was also a decrease in systolic (p = 0.012) and mean arterial pressure (p = 0.02). The current hygiene protocol reduced the inflammation degree of DRS and promoted an improvement of local inflammatory factors and a reduction in the systolic arterial pressure of the patients.

Strategies for Preventing and Treating Oral Mucosal Infections Associated with Removable Dentures: A Scoping Review

“…In the study by Ribeiro et al (2022) [ 144 ] assessing the quality of life and satisfaction of individuals using complete dentures concerning hygiene protocols, four protocols were examined: brushing associated with immersion in 0.25% sodium hypochlorite, 0.15% triclosan, effervescent tablets (BonyfAG), or effervescent tablets (BonyfAG) combined with palatal brushing. The findings revealed an enhancement in overall patient satisfaction, satisfaction with the maxillary prosthesis, comfort with the maxillary prosthesis, and retention of the maxillary prosthesis [ 144 ]. Conversely, another study explored the connection between the hygiene of complete dentures and the quality of life related to oral health in completely edentulous individuals [ 128 ].…”

“…The existing literature underscores the importance of concurrently assessing the clinical efficacy of treatment and maintenance therapy for DRS alongside ongoing management of the patient’s existing chronic conditions [ 75 , 144 ], highlighting the significance of multidisciplinary investigations. This holistic approach towards patients with concurrent chronic diseases who are positive for DRS was executed within distinct cohorts manifesting gastrointestinal pathology (predominantly chronic gastritis, Group I), type 2 diabetes (Group II), and cardiovascular system pathology (primarily coronary heart disease; Group III) [ 75 ].…”

“…The outcomes revealed that the implemented hygiene protocol effectively diminished the inflammation associated with DRS. Furthermore, an improvement in local inflammatory factors and a reduction in systolic arterial pressure were observed among the participants [ 144 ].…”

“…The by-title/abstract screening resulted in the exclusion of 452 articles The full text of the remaining 131 articles was screened, and 104 of them were selected [2 16,18,22-37,40,41,43-45,47,49-88,90,92-116]. Another 38 articles were found in the gra literature, 19 by a senior expert indication [19,39,89,[117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132], and 19 from searchin citations [38,48,[133][134][135][136][137][138][139][140][141][142][143][144][145][146][147][148][149], resulting in a total of 142 articles for the scoping review according to the study workflow in Figure 1. Another 21 articles were used to describe th essential definitions in Sections 2.2.1 and 3 [1,17,20,21,42,…”

“…Recent clinical studies suggest that the combination of brushing with sodium hypochlorite stands out as a highly effective method for biofilm control and the prevention of DRS. Notably, this approach exhibits safety concerning its impact on the resinous materials used in prosthesis fabrication [ 88 , 116 , 129 , 144 ]. These findings have clinical significance, given the simplicity of the brushing method and the ready availability and affordability of sodium hypochlorite.…”