More than a decade after the introduction of the human papillomavirus (HPV) vaccine in the United States, only 51.1% of adolescents have completed the vaccine series, while a greater number (68.1%) received at least 1 dose. 1 The suboptimal series completion rate in the United States is partly attributable to the barriers, including unawareness of or forgetting the need for additional doses, lack of insurance coverage or health care professional recommendations, and less frequent contact with the medical system. 2,3 To simplify the recommendations, trials are evaluating the efficacy of a singledose regimen. 4 In this study, we investigated HPV infection prevalence among women by number of vaccine doses received.
MethodsThis cross-sectional study analyzed National Health and Nutritional Examination Survey (NHANES) 2009 to 2016 data, which are a stratified multistage probability sample of the US population. Demographic characteristics and immunization history were self-reported and collected by trained interviewers during a home interview. Sexual behavior data were self-reported by participants in the Mobile Examination Center. Participants provided self-collected cervicovaginal swab specimens. The specimens were evaluated by polymerase chain reaction followed by type-specific hybridization.Details of the survey questionnaire, sample collection, and laboratory methods are available elsewhere. 5 We identified women aged 18 to 26 years at the time of survey participation with nonmissing HPV vaccination and HPV test data. Nationally representative estimates for prevalence and the representative population counts were computed using NHANES sampling weights. The survey weight-adjusted Wald F test was used to examine the difference in the prevalence of HPV infection (4-valent vaccine types [HPV types 6, 11, 16, and 18]; cross-protection types [HPV types 31, 33, and 45]; and other high-risk types [HPV types 35, 39, 51, 52, 56, 58, 59, and 68]) by the number of doses received. The differences in predicted probability for HPV types 6, 11, 16, and 18 by number of vaccine doses and by the levels of risk factors were estimated using a multivariable logistic regression model. The model was adjusted simultaneously for age as a linear term, race/ethnicity, age at sexual debut, and lifetime number of male sexual partners. Statistical significance was tested at 2-sided P < .05. All analyses were performed with SAS software version 9.4 (SAS Institute) using SAS PROC SURVEY procedures, which included weight, cluster, and strata statements, to incorporate sampling weights and to adjust for the complex survey design.This study was deemed exempt from review and requirements for patient informed consent by the institutional review board of the University of Texas Health Science Center owing to the use of publicly available and anonymized data. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.Author affiliations and article information are listed at the end of this...