Effect of a hemiuroid trematode on the hemocyte immune parameters of the cockle Anadara trapezia

Dang, Cécile; Cribb, Thomas H.; Osborne, Geoffrey W.; Kawasaki, Minami; Bedin, Anne‐Sophie; Barnes, Andrew C.

doi:10.1016/j.fsi.2013.07.010

Cited by 18 publications

(10 citation statements)

References 48 publications

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“…Analogous to fish and reptiles, bivalves store their Hb within nucleated erythroid-like cells. Trematode infestation of the Sydney cockle, Anadara trapezia , induced measureable increases in circulating erythrocyte numbers, over double compared to non-parasitised animals [138]. These data add support to earlier findings demonstrating the immune competence of erythrocytes [117].…”

Section: An Emerging Role For Invertebrate (Bivalve) Hemoglobin In Insupporting

confidence: 85%

“…In blue-blooded (Cu) and red-blooded (Fe) snails, Hc and Hb are synthesised inside specialist rhogocytes (pore cells) and then released into the plasma [136, 137]. Bivalves lack Hc, instead they utilise cell-bound Hbs which are structurally similar to vertebrate Hbs [5, 138]. Analogous to fish and reptiles, bivalves store their Hb within nucleated erythroid-like cells.…”

Section: An Emerging Role For Invertebrate (Bivalve) Hemoglobin In Inmentioning

confidence: 99%

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Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin

Coates

Decker

2016

Cell. Mol. Life Sci.

123

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It is now well documented that peptides with enhanced or alternative functionality (termed cryptides) can be liberated from larger, and sometimes inactive, proteins. A primary example of this phenomenon is the oxygen-transport protein hemoglobin. Aside from respiration, hemoglobin and hemoglobin-derived peptides have been associated with immune modulation, hematopoiesis, signal transduction and microbicidal activities in metazoans. Likewise, the functional equivalents to hemoglobin in invertebrates, namely hemocyanin and hemerythrin, act as potent immune effectors under certain physiological conditions. The purpose of this review is to evaluate the true extent of oxygen-transport protein dynamics in innate immunity, and to impress upon the reader the multi-functionality of these ancient proteins on the basis of their structures. In this context, erythrocyte–pathogen antibiosis and the immune competences of various erythroid cells are compared across diverse taxa.Electronic supplementary materialThe online version of this article (doi:10.1007/s00018-016-2326-7) contains supplementary material, which is available to authorized users.

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Section: An Emerging Role For Invertebrate (Bivalve) Hemoglobin In Insupporting

confidence: 85%

Section: An Emerging Role For Invertebrate (Bivalve) Hemoglobin In Inmentioning

confidence: 99%

Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin

Coates

Decker

2016

Cell. Mol. Life Sci.

123

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“…cells was not observed. Haemocytes infiltrating infected tissues were amoebocytes, rather than the nucleated erythrocytes that also circulate in A. trapezia haemolymph (Dang et al 2013). Amoebocyte abundances were relatively low in A. trapezia connective tissues, and increased moderately in proximity to colonizing Perkinsus sp.…”

Section: Rftm and Histological Assaysmentioning

confidence: 95%

Perkinsus sp. infections and in vitro isolates from Anadara trapezia (mud arks) of Queensland, Australia

Dang¹,

Dungan²,

Scott³

et al. 2015

Dis. Aquat. Org.

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Perkinsus sp. protists were found infecting Anadara trapezia mud ark cockles at 6 sites in Moreton Bay, Queensland, Australia, at prevalences of 4 to 100% during 2011 as determined by surveys using Ray's fluid thioglycollate medium. Perkinsus sp. lesions were found among gill and visceral connective tissues in histological samples from several cockles, where basophilic, eccentrically vacuolated Perkinsus sp. signet ring trophozoites and proliferating, Perkinsus sp. schizont cells were documented. Two Perkinsus sp. isolates were propagated in vitro during August 2013 from gill tissues of a single infected A. trapezia cockle from Wynnum in Moreton Bay. DNA from those isolate cells amplified universally by a Perkinsus genus-specific PCR assay, and rDNA-internal transcribed spacer sequences respectively grouped them with P. olseni and P. chesapeaki in phylogenetic analyses. This is the first report of P. chesapeaki in Australia, and the first report of a P. chesapeaki in vitro isolate from an Australian mollusc host. Although P. olseni was originally described in 1981 as a pathogen of abalone in South Australia, and has subsequently been identified as a prevalent pathogen of numerous other molluscs worldwide, this is also the first report of a P. olseni-like in vitro isolate from an Australian mollusc host.

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“…Trematode infection increases the total circulating hemocytes count (THC) and decreases their phagocytic capacity, thus modulating the cockle immune system (Dang et al 2013). Consequently, cockles infected with B. minimus should be less resistant to infection by the other trematode species than cockles without B. minimus, or vice-versa cockles with rich and abundant metacercariae community could be more sensitive to B. minimus infection.…”

Section: Trematode Metacercariae Associated Communitymentioning

confidence: 99%

Review: Bucephalus minimus, a deleterious trematode parasite of cockles Cerastoderma spp.

2015

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Trematodes are the most prevalent and abundant macroparasites in coastal waters. They display a complex life cycle with alternation of free-living and parasitic stages generally involving three host species. The most deleterious stage is in the first intermediate host (a mollusc) where the parasite penetrates as miracidium larvae and asexually multiplicates in sporocysts/rediae to provide cercariae larvae. However, due to basic low prevalence in ecosystems, this system remains difficult to study. Taking the example of the cockle (Cerastoderma edule), an exploited bivalve along North-Eastern Atlantic coasts, and Bucephalus minimus, its most prevalent parasite as first intermediate host, we summarised the 51 most relevant papers (1887-2015). Besides, a 16-year monthly monitoring was performed at Banc d'Arguin (Atlantic coast of France), and allowed to obtain a sufficient number of infected cockles (276 out of 5,420 individuals) in order to provide new information concerning this parasite/host system. Sporocysts (diameter 80-500 μm) and developing cercariae (length 300-500 μm) are not visible before cockle reaches 16-mm shell length and then prevalence increases with host size. Seasonality of infection was not observed but variation of prevalence was significant among years and negatively correlated to the temperature of the former year, which could correspond to the period of infection by miracidium. Seven other species of trematode were identified in cockles as second intermediate host. For six of them, metacercariae abundance per individual was 2 to 12 folds higher in B. minimus-infected cockles, exacerbating the potential negative impact on host. From the parasite point of view, metacercariae can be considered as hitchhikers, taking advantage of the abnormal migration of B. minimus-infected cockles to the sediment surface where they become more vulnerable to predators that are also the final hosts of many of these parasites.

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Effect of a hemiuroid trematode on the hemocyte immune parameters of the cockle Anadara trapezia

Cited by 18 publications

References 48 publications

Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin

Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin

Perkinsus sp. infections and in vitro isolates from Anadara trapezia (mud arks) of Queensland, Australia

Review: Bucephalus minimus, a deleterious trematode parasite of cockles Cerastoderma spp.

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