Effect of a family history of psoriasis and age on comorbidities and quality of life in patients with moderate to severe psoriasis: Results from the <scp>ARIZONA</scp> study

López-Estebaranz, J.L.; Sánchez‐Carazo, J.L.; Sulleiro, Sara

doi:10.1111/1346-8138.13157

Cited by 35 publications

(39 citation statements)

References 28 publications

(48 reference statements)

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“…A multicentre, cross‐sectional, observational study conducted at 68 dermatologic centres across Spain with 1022 adult patients analysed the impact of family history of psoriasis and age on comorbidity and quality of life in patients. A significantly higher Dermatology Quality of Life Index (DLQI) appeared in younger age groups from 18 to 30 and 31 to 60 years with a DLQI of 5.1 ± 5.3 and 5.7 ± 6.5, respectively, compared to 3.8 ± 5.1 for the >60‐year group . Similar results were provided from a study on the effect of age on quality of life and long‐term outcomes in 114 individuals, which concluded that depression, social discrimination and a greater DLQI are more frequent in patients with early‐onset psoriasis …”

Section: Introductionmentioning

confidence: 54%

The impact of age on psoriasis health care in Germany

Spehr

Körber

Augustin

2017

Acad Dermatol Venereol

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Section: Introductionmentioning

confidence: 54%

The impact of age on psoriasis health care in Germany

Spehr

Körber

Augustin

2017

Acad Dermatol Venereol

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“…Although there are some studies2526 that family history is associated with early onset age, but it was difficult to find a study to explain a relationship between family history and disease severity. However, López-Estebaranz et al27 recently presented that the severity of psoriasis was not affected by the presence of a family history. Therefore, further studies are necessary to determine the association between family history and disease severity.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

et al. 2017

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BackgroundPsoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date.ObjectiveTo understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea.MethodsThis multicenter, non-interventional, cross-sectional study recruited 1,278 adult patients with psoriasis across 25 centers in Korea in 2013. Various clinical data including PASI, BSA, DLQI, SF-36 and PASE were collected.ResultsA total of 1,260 patients completed the study (male:female=1.47:1). The mean age was 47.0 years with a distribution mostly in the 50s (24.9%). Early onset (<40 years) of psoriasis accounted for 53.9% of patients. The mean disease duration was 109.2 months; mean body mass index was 23.9 kg/m2; and 12.7% of patients had a family history of psoriasis. Plaque and guttate types of psoriasis accounted for 85.8% and 8.4%, respectively. Patients with PASI ≥10 accounted for 24.9%; patients with body surface area ≥10 were 45.9%. Patients with DLQI ≥6 accounted for 78.8%. Between PASI <10 and PASI ≥10 groups, significant difference was noted in age at diagnosis, disease duration, blood pressure, waist circumference of female, and treatment experiences with phototherapy, systemic agents, and biologics.ConclusionThis was the first nationwide epidemiologic study of patients with psoriasis in Korea and provides an overview of the epidemiologic characteristics and clinical profiles of this patient population.

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“…On the contrary, in our study having a familial history of psoriasis did not present a relationship with MDA. Similarly, a recent study showed that the severity of psoriasis and the proportion of patients with comorbidities were not affected by the presence of a family history of psoriasis [26]. …”

Section: Discussionmentioning

confidence: 99%

Minimal disease activity and impact of disease in psoriatic arthritis: a Spanish cross-sectional multicenter study

Queiró

Cañete

Montilla³

et al. 2017

Arthritis Res Ther

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BackgroundPatients with psoriatic arthritis (PsA) experience functional impairment and reduced quality of life, and thus patient global assessment in PsA is explained mainly by the physical, but also by the psychological, aspect of the disease. To assess the prevalence of minimal disease activity (MDA) in Spanish patients with PsA, we examined their characteristics and the association between MDA and the impact of the disease as assessed by the PsA Impact of Disease (PsAID) questionnaire.MethodsA cross-sectional multicenter study was carried out in patients who fulfilled the Classification for Psoriatic Arthritis (CASPAR) criteria with at least 1 year of disease duration, and who were treated with biological or conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs) according to routine clinical practice in Spain. Patients were considered in MDA if they met at least 5/7 of the MDA criteria. The association between MDA and the recently developed PsAID questionnaire was also recorded.ResultsOf 227 patients included, 133 (58.6%) were in the MDA state (52% with antitumor necrosis factor (anti-TNF)α monotherapy, 24% with csDMARD monotherapy, and 24% with anti-TNFα in combination with csDMARD). Using multivariate logistic regression analysis, male gender (odds ratio (OR) 2.74, p = 0.001), a sedentary lifestyle (OR 3.13, p = 0.002), familial history of PsA (OR 0.38, p = 0.036), C-reactive protein (CRP) level (OR 0.92, p = 0.010), and use of corticoids (OR 0.33, p = 0.007) were considered features related to MDA. MDA patients had a significantly lower impact of the disease according to PsAID (mean total score (SD): MDA 3.3 (3.1) vs. non-MDA 7.1 (5.2); p < 0.001).ConclusionsNearly 60% of Spanish PsA patients achieve MDA in routine clinical practice. MDA remains one of the most useful therapeutic targets for PsA since patients who reached this state also had a significantly lower impact of disease according to PsAID.

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Effect of a family history of psoriasis and age on comorbidities and quality of life in patients with moderate to severe psoriasis: Results from the ARIZONA study

Cited by 35 publications

References 28 publications

The impact of age on psoriasis health care in Germany

The impact of age on psoriasis health care in Germany

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)

Minimal disease activity and impact of disease in psoriatic arthritis: a Spanish cross-sectional multicenter study

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