Effect of a diphenylethylenediamine platinum complex on steroidogenesis in rats

Sergejew, T.; Hartmann, Rolf W.

doi:10.1016/0960-0760(96)00035-0

Cited by 13 publications

(15 citation statements)

References 17 publications

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“…The results of this in vitro study were compared with those of an earlier in vivo study on the same tumors; see next paragraph. Due to the capability of 3-PtSO 4 complexes to interfere with DNA replication [15] as well as with early steps of estrogen biosynthesis [13], their effect on the hormone-sensitive but not on the hormone-insensitive murine breast cancer must be weaker in the cell culture than in the animal experiment, in which both interactions can take place.…”

Section: Resultsmentioning

confidence: 99%

“…Analogous experiments with rac-3-PtSO 4 were not performed, since, as a rule, 3. The complexes are able to decrease the physiological estrogen level in rodents, apparent from the reduction of the uterus weights through an interference with the ovarian steroid biosynthesis as shown for meso-3-PtSO 4 [13].…”

Section: Discussionmentioning

confidence: 96%

“…It is not clear, whether the impaired development of the ovarian follicles is due to the low estrogen level caused by an inhibited expression of steroidogenic enzymes by meso-3-PtSO 4 [13], or, at least partially, to a general ovarian toxicity. Numerous experimental results point to the fact that estrogens are important for a functioning ovarian folliculogenesis ( [26] and references cited therein).…”

Section: Histological Examination Of Ovary Uterus and Tumor Of Meso-mentioning

confidence: 95%

“…The steps at which the testosterone biosynthesis is impaired by meso-3-PtSO 4 and cDDP, respectively, has been described by Sergejew and Hartmann [13], and a possible involvement of the hypothalamic pituitary axis in this process could be excluded.…”

Section: Reduction Of the E 2 Plasma Level By Meso-3-ptsomentioning

confidence: 96%

“…First clues to the fact that inhibitory effects on the estrogen biosynthesis could be involved in the antibreast cancer activity of 3-PtLLЈ complexes, came from Sergejew and Hartmann [13]. They found that meso-3-PtSO 4 caused a reduced expression of steroidogenic enzymes in gonads of male rats.…”

Section: -Ptllјmentioning

confidence: 98%

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[1, 2‐Bis(2, 6‐difluoro‐3‐hydroxyphenyl)ethylene‐diamine]platinum(II) Complexes, Compounds for the Endocrine Therapy of Breast Cancer ‐ Mode of Action I: Antitumor Activity Due to the Reduction of the Endogenous Estrogen Level

Schertl

Hartmann

Batzl‐Hartmann

et al. 2004

Archiv der Pharmazie

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Aqua[meso-1, 2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II) (meso-3-PtSO(4)) and its racemate (rac-3-PtSO(4)) are highly active on the hormone-sensitive MXT-M-3, 2 breast cancer of the mouse. In vitro, on the MXT(+) cell culture derived from this tumor, however, they are inactive (meso-3-PtSO(4)) or moderately active (rac-3-PtSO(4)) in concentrations corresponding to levels of these drugs in animal experiments. The in vivo effect is mainly caused by a reduction of the endogenous estrogen level in the host animals due to an interference with the ovarian steroid biosynthesis as demonstrated for meso-3-PtSO(4). Therefore, a reversal of the breast cancer inhibiting effect of meso-3-PtSO(4) can be achieved by simultaneous estrone administration. Histological results on ovaries, uterus, and tumor of meso-3-PtSO(4)-treated mice also favor such a mode of action. However, especially for rac-3-PtSO(4) cytotoxic effects contributing to the anti-breast cancer activity cannot be excluded. Considerations on the mode of action of Pt-complexes which inhibit breast cancer by interference with estrogen receptor mediated processes of growth control and with DNA replication are presented.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Histological Examination Of Ovary Uterus and Tumor Of Meso-mentioning

confidence: 95%

Section: Reduction Of the E 2 Plasma Level By Meso-3-ptsomentioning

confidence: 96%

Section: -Ptllјmentioning

confidence: 98%

See 3 more Smart Citations

[1, 2‐Bis(2, 6‐difluoro‐3‐hydroxyphenyl)ethylene‐diamine]platinum(II) Complexes, Compounds for the Endocrine Therapy of Breast Cancer ‐ Mode of Action I: Antitumor Activity Due to the Reduction of the Endogenous Estrogen Level

Schertl

Hartmann

Batzl‐Hartmann

et al. 2004

Archiv der Pharmazie

Self Cite

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Stereoselective Interaction between DNA and Stable Chiral Surfaces Modified with 1,2‐Diphenylethylenediamine Enantiomers

Wang

Zhou

et al. 2010

Electroanalysis

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This work described an interesting phenomenon of the stereoselective adsorption behaviors of DNA on stable chiral surfaces which were modified with 1,2-diphenylethylenediamine enantiomers on gold electrodes. The modification process and electrochemical characterization of the chiral surfaces were measured by cyclic voltammetry (CV). The stereoselective adsorption behaviors of DNA on the two chiral surfaces were investigated via atomic force microscopy (AFM), CV, electrochemical impedance spectroscopy (EIS) and quartz crystal microbalance (QCM). All results confirmed that (1R,2R)-1,2-diphenylethylenediamine modified surface had stronger interaction with DNA molecules than (1S,2S)-1,2-diphenylethylenediamine modified surface, and the chirality of the surfaces created an different effect on the morphology and adsorption quantity of DNA.

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Selective response of antigen‐antibody reactions on chiral surfaces modified with 1,2‐diphenylethylenediamine enantiomers

Zhou

Wang

Qiao

et al. 2011

Surface & Interface Analysis

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Effect of a diphenylethylenediamine platinum complex on steroidogenesis in rats

Cited by 13 publications

References 17 publications

[1, 2‐Bis(2, 6‐difluoro‐3‐hydroxyphenyl)ethylene‐diamine]platinum(II) Complexes, Compounds for the Endocrine Therapy of Breast Cancer ‐ Mode of Action I: Antitumor Activity Due to the Reduction of the Endogenous Estrogen Level

[1, 2‐Bis(2, 6‐difluoro‐3‐hydroxyphenyl)ethylene‐diamine]platinum(II) Complexes, Compounds for the Endocrine Therapy of Breast Cancer ‐ Mode of Action I: Antitumor Activity Due to the Reduction of the Endogenous Estrogen Level

Stereoselective Interaction between DNA and Stable Chiral Surfaces Modified with 1,2‐Diphenylethylenediamine Enantiomers

Selective response of antigen‐antibody reactions on chiral surfaces modified with 1,2‐diphenylethylenediamine enantiomers

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