Effect of a Detergent on Gastrointestinal Absorption of a Steroid

Gantt, ClarenceL.; Gochman, Nathan; Dyniewicz, J. M.

doi:10.1016/s0140-6736(61)90065-4

Cited by 29 publications

(1 citation statement)

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“…The addition of Tween 80, previously reported to enhance the absorption of spironolactone (Gantt, Gochman, and Dymiewicz, 1961), has now been retracted (Gantt, et al, 1962) as it appears that whilst encapsulating spironolactone with Tween 80 the small particle size was preserved and this was responsible for the improved absorption rather than the addition of the detergent itself. The four-hour plasma level of spironolactone metabolite represents the peak concentration following oral administration of the drug (Gantt, Gochman, and Dyniewicz, 1961). The higher plasma values found in patients requiring larger doses of spironolactone (whichever preparation was used) suggests that poor absorption of the drug was not the principal cause of the need for the higher dosages.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites

Shaldon¹,

Ryder²,

Garsenstein³

1963

Gut

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EDITORIAL SYNOPSIS In eight patients with cirrhosis and stable ascites controlled on chlorothiazide and spironolactone, a small particle preparation of spironolactone (Aldactone A) was as effective, at one quarter the dosage, as conventional spironolactone (Aldactone). Plasma spironolactone metabolite levels and urinary excretion of spironolactone metabolite were equivalent with both preparations. The variable dosage requirement of spironolactone in patients with cirrhosis and ascites is discussed in relation to these observations.

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Section: Discussionmentioning

confidence: 99%

A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites

Shaldon¹,

Ryder²,

Garsenstein³

1963

Gut

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Sorptionsvermittler in der Biopharmazie

Ritschel

1969

Angewandte Chemie

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Die Absorption von Arzneistoffen hiingt von den chemisch-physikalischen Eigenschaften der Substamen ab. Mit Hive von , ,Sorptionsvermittlern" gelingt es, Arzneistoffe, die schwer, uberhaupt nicht oder nur langsam absorbierbar sind, in die Haut und in die Schleimhaut eindringen (penetrieren) oder h r c h diese hindurchdringen (permeieren) zu lassen. Die Suche nach derartigen Hilfstoffen sowie die Aufklarung ihrer Wirkungsprinzipien geh6ren in den Bereich der Biopharmazie.

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Sorption Promotors in Biopharmaceutics

Ritschel

1969

Angew. Chem. Int. Ed. Engl.

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The absorption of drugs depends on the physico‐chemical properties of the constituent substances. Drugs that are absorbed only with difficulty or only slowly, or even not at all, can be made to penetrate into the skin and the mucous membrane (penetration) or to pass through them (permeation) with the aid of “sorption promotors”. The search for substances of this type and the elucidation of their principles of action form part of the field of biopharmaceutics.

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Effect of a Detergent on Gastrointestinal Absorption of a Steroid

Cited by 29 publications

References 1 publication

A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites

A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites

Sorptionsvermittler in der Biopharmazie

Sorption Promotors in Biopharmaceutics

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