Effect of a Combination of Ecabet Sodium and Cimetidine on Experimentally Induced Gastric Lesions and Gastric Mucosal Resistance to Ulcerogenic Agents in Rats.

Kinoshita, Mine; Noto, Tsunehisa; Tamaki, Hiroyuki

doi:10.1248/bpb.18.223

Cited by 47 publications

(43 citation statements)

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“…19) The formation of gastric mucosal lesions by necrotizing agents such as HCl and EtOH has been reported to involve the depression of these gastric defensive mechanisms. 20) HCl-EtOH-induced gastric ulcers also promote stasis in gastric blood flow which contributes to the development of the hemorrhagic and necrotic aspects of tissue injury. 2) It has been found that EtOH-induced ulcers are not inhibited by antisecretory agents such as cimetidine, but are inhibited by agents that enhance mucosal defensive factors such as prostaglandins.…”

Section: Resultsmentioning

confidence: 99%

Antiulcerogenic Activity of Four Extracts Obtained from the Bark Wood of <i>Quassia amara</i> L. (Simaroubaceae)

Toma

Gracioso

Andrade³

et al. 2002

Biological & Pharmaceutical Bulletin

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Gastric ulcers are among the most important diseases in the world. The gastric mucosa is continuously exposed to potentially injurious agents such as acid, pepsin, bile acids, food ingredients, bacterial products, and drugs. 1) These agents have been implicated in the pathogeneses of gastric ulcer, such as an increase in gastric acid and pepsin secretion, a decrease in gastric blood flow, the suppression of endogenous generation of prostaglandins, inhibition of mucosal growth and cell proliferation, and alteration of gastric mobility.2)The current therapy for this disease continues to have, as one of its major goals, the control of Helicobacter pylori as well as H ϩ /K ϩ -ATPase, acid secretion and a subsequent reversal of mucosal damage and inflammation. 3)Many pharmaceutical products have been employed for the treatment of gastroduodenal ulcer and peptic disease, and for decreasing mortality and morbidity rates, but they are not completely effective and produce many adverse effects. Moreover, these pharmaceutical products are too expensive. 4)Plant extracts are some of the most attractive sources of new drugs and have been shown to produce promising results for the treatment of gastric ulcer. 5)Simaroubaceae is a large botanical family with pantropical distribution; only a few representatives occur in temperate regions. Quassia amara L., a representative of this family, is a neotropical forest shrub or small tree reputed in traditional medicine to have good effect on stomach diseases, especially gastric ulcers. In Brazil, this species is found in a region from the border with Guiana to the state of Maranhão. It is popularly known in Latin American as "Amargo", "Hombre Grande", "Simaruba", "Pau Quassia", "Murubá", "Murupá" and "Quina de Caiena". 6)This plant is a source of several compounds which include both b-carbonile and cantin-6 alkaloids, as well as, primarily, the bitter components known as quassinoids, a group of substances belonging to the terpens class. Antimalarial, antifeedant and antifertility pharmacological activities are atributted to these quassinoids. 7)In considering the use of this plant in Brazilian folk medicine and the several chemical substances isolated and identified from Quassia amara bark, we have performed a study of the antiulcerogenic effects for four different extracts of this species using standard rodent models of induced gastric ulcer. Quassia amara L., a neotropical forest shrub of the Simaroubaceae family, is widely used in Caribbean folk medicine and in some northern states of Brazil for the treatment of gastric ulcers. This plant is a source of numerous compounds including both b b-carbonile and cantin-6 alkaloids as well as, primarily, the bitter compounds known as quassinoids. We analyzed the possible antiulcerogenic activities of four extracts of different polarities: 70% ethanol (70% EtOH), 100% EtOH, 100% dichloromethane (DCM), and 100% hexane (HEX) obtained from Quassia amara bark. All extracts, administered at doses of 5000 mg/kg orally and 1000 mg/kg intraperitonea...

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Section: Resultsmentioning

confidence: 99%

Antiulcerogenic Activity of Four Extracts Obtained from the Bark Wood of <i>Quassia amara</i> L. (Simaroubaceae)

Toma

Gracioso

Andrade³

et al. 2002

Biological & Pharmaceutical Bulletin

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“…The ability of gastric mucosa to resist injury by endogenous secretions (acid, pepsin and bile) and ingested irritants (e.g., alcohol), can be attributed to a number of factors that have been referred to collectively as mucosal defense [28] . Gastric mucosal lesions induced by necrotizing agents such as ethanol and strong alkalis are due to depression of the gastric defensive mechanisms [29] . Although ethanol-induced ulcers are not inhibited by anti-secretory agents such as cimetidine, they are inhibited by agents that enhance mucosal defensive factors such as prostoglandins [30] .…”

Section: Discussionmentioning

confidence: 99%

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Mofleh

Alhaider²,

Mossa³

et al. 2007

WJG

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INTRODUCTIONPeptic ulcer is one of the most common gastrointestinal diseases. Nowadays proton pump inhibitors and H2-recptor antagonists are the most widely used drugs to treat peptic ulcer disease. However, the use of these antisecretory drugs may be associated with adverse events and ulcer relapse [1] . Thus, there is a need for more effective, less toxic and cost-effective anti-ulcer agents. In recent years, a widespread search has been launched to identify new anti-ulcer drugs from natural sources. Spices comprising the most important products used for flavouring foods and medicinal herbs are considered nowadays as potential bioactive agents that can interfere positively or negatively with different cellular processes. They are extensively used in medicine, pharmaceuticals, perfumery and cosmetics. Additionally they possess antioxidant, antispasmodic, carminative, anti-inflammatory and other properties [2] . A number of spices, namely large cardamom [3] , black pepper [4] , caraway [5] , cardamom [6] , clove [7] , coriander [8] , ginger [9] , peppermint [10] , saffron [11] , turmeric [12] among others have been shown to possess significant gastroprotective activities. The fruits of anise plant, pimpinella anisum L. are locally known as aniseed and yansoon. The powder and concoction of anise in hot water are used as carminatives, antiseptics, diuretics, digestives, aphrodisiacs, and as a remedy for insomnia and constipation [13] . Furthermore, anise is used to promote digestion, improve appetite, alleviate cramps and nausea, and relieve flatulence and colic. In Unani and Arabian traditional medicine, anise fruit and its oil have been used for the treatment of various conditions including dyspepsia, nausea, abdominal colic, RAPID COMMUNICATIONAqueous suspension of anise "Pimpinella anisum " protects rats against chemically induced gastric ulcers Ibrahim Abstract AIM:To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, "Pimpinella anisum L." on experimentally-induced gastric ulceration and secretion in rats. METHODS:Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCl and indomethacin. Anti-secretory studies were undertaken using pylorusligated Shay rat technique. Levels of gastric non-protein sulfhydryls (NP-SH) and wall mucus were estimated and gastric tissue was also examined histologically. Anise aqueous suspension was used in two doses (250 and 500 mg/kg body weight) in all experiments. RESULTS:Anise significantly inhibited gastric mucosal damage induced by necrotizing agents and indomethacin. The anti-ulcer effect was further confirmed histologically. In pylorus-ligated Shay rats, anise suspension significantly reduced the basal gastric acid secretion, acidity and completely inhibited the rumenal ulceration. On the other hand, the suspension significantly replenished ethanol-induced depleted levels of gastric mucosal NP-SH a...

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“…Gastric ulcer seems to be generated from over-secretion of gastric juice and imbalance of defensive and aggressive factors involved in maintaining gastric mucosal integrity (McQuaid and Isenberg, 1992). The formation of gastric mucosal lesions by necrotizing agents such as HCl and ethanol has been shown to be associated with depression of gastric defensive mechanisms (Kinoshita et al, 1995). Therefore, acid production regulators such as proton pump inhibitors widely used in clinic (Pisegna, 2002), appear to accelerate the healing of gastric ulcers and gastritis by potent and longlasting antisecretory actions (Welage, 2003).…”

Section: Effect Of Mb Extract-components On the Gastric Secretionmentioning

confidence: 99%

Anti-gastritic Effects of Magnolol and Honokiol from the Stem Bark of Magnolia obovata

Cho¹,

Lee²,

Bae³

et al. 2008

Biomolecules and Therapeutics

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− In this study we investigated the effects of Magnolia Bark (MB) extract and its constituents, such as honokiol and magnolol, on gastritis in rats and the growth of human gastric cancer cells. The MB extract, honokiol, and magnolol showed the acid-neutralizing capacities, the antioxidant activities, and the inhibitory effect on the growth of Helicobacter pylori (H. pylori.) at the dose of 50 µg/ml and over, which is equivalent to that of ampicillin (100 µg/ml). Honokiol and magnolol had no significant cytotoxicity to human gastric caner cells (AGS and SNU638). However, the MB extract had cytotoxic activity against AGS gastric cancer cell. The MB extract, honokiol, and magnolol significantly inhibited HCl·ethanol-induced gastric lesions without clear change of mucus content. In pylorus ligated rats, honokiol significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. Magnolol increased the mucus content to almost the same as the control group at oral doses of 50 mg/kg. Therefore, we could guess that antigastritic action of honokiol and magnolol may be associated with the antioxidant activities, acid-neutralizing capacities, inhibition of secretion in gastric acid, and anti-H. pylori action. From these results, we could suggest that MB extract and its constituents, such as honokiol and magnolol, may be useful for the treatment and/or protection of gastritis.

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Effect of a Combination of Ecabet Sodium and Cimetidine on Experimentally Induced Gastric Lesions and Gastric Mucosal Resistance to Ulcerogenic Agents in Rats.

Cited by 47 publications

References 0 publications

Antiulcerogenic Activity of Four Extracts Obtained from the Bark Wood of <i>Quassia amara</i> L. (Simaroubaceae)

Antiulcerogenic Activity of Four Extracts Obtained from the Bark Wood of <i>Quassia amara</i> L. (Simaroubaceae)

Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

Anti-gastritic Effects of Magnolol and Honokiol from the Stem Bark of Magnolia obovata

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