Effect of a combination GOS/FOS® prebiotic mixture and interaction with calcium intake on mineral absorption and bone parameters in growing rats

Bryk, Gabriel; Coronel, Magalí Zeni; Pellegrini, G; Mandalunis, Patricia; Rio, María Ester; Portela, María Luz Pita Martín de; Zeni, Susana Noemí

doi:10.1007/s00394-014-0768-y

Cited by 55 publications

(48 citation statements)

References 46 publications

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“…We previously demonstrated that a combination of shortand long-chain inulin-type fructans increases the number of Lactobacilli in feces and enhances Ca and P absorption and bone mineralization during normal growth [20]. The hypothesis of the present report was that an increment in colonic mineral absorption as a result of feeding the prebiotic mixture would supply an extra amount of Ca and P to support the catch-up growth that would allow recovery from protein malnutrition.…”

Section: Introductionmentioning

confidence: 84%

“…P and Mg concentration in serum, feces, diet and femur was evaluated following habitual methods using an automated analyzer (Abbott Laboratories, Abbott Park, IL, USA). Serum bone alkaline phosphatase (BAP) (IU/L) was measured using a colorimetric method after bone isoenzyme precipitation with wheat germ lectin [20]. Serum type I collagen telopeptide (CTX) (ng/mL) was assessed employing immunoassay (ELISA) (Rat Laps.…”

Section: Biochemical Determinationmentioning

confidence: 99%

“…Ca concentration in serum, feces, diet and femur was determined by atomic absorption spectrophotometry [20]. Lanthanum chloride (6500 mg/L in the final solution) was added as interference suppressor.…”

Section: Biochemical Determinationmentioning

confidence: 99%

“…Feces were dried under infrared light and pounded. Diets and feces were digested with nitric acid using Parr bombs to evaluate Ca, P and magnesium (Mg) content [20].…”

Section: Ca P and Mg Absorptionmentioning

confidence: 99%

“…NDFO modifies the colonic microbiota increasing the proliferation and activity of beneficial bacteria against pathogenic species [16][17][18][19]. This shift in the composition of the enteric microbiota dramatically changes the bacterial metabolic products released into the gut.…”

Section: Introductionmentioning

confidence: 99%

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Effect of a mixture of GOS/FOS® on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats

et al. 2015

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Section: Introductionmentioning

confidence: 84%

Section: Biochemical Determinationmentioning

confidence: 99%

Section: Biochemical Determinationmentioning

confidence: 99%

“…Feces were dried under infrared light and pounded. Diets and feces were digested with nitric acid using Parr bombs to evaluate Ca, P and magnesium (Mg) content [20].…”

Section: Ca P and Mg Absorptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of a mixture of GOS/FOS® on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats

et al. 2015

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Immune Response of Fructo and Galacto‐Oligosaccharides

Vijayasarathy¹,

Prabhu²,

Pavithra³

et al. 2022

Prebiotics and Probiotics in Disease Regulation and Management

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Prebiotics and Bone

Whisner

Weaver²

2017

Advances in Experimental Medicine and Biology

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Recent advancements in food science have resulted in the extraction and synthesis of novel dietary fibers or prebiotics. Subsequently, great interest has emerged in developing strategies to improve metabolic conditions like osteoporosis by modulating the intestinal microbiome with fiber. Prebiotics have been shown to increase calcium absorption in the lower gut of both animals and humans as well as improve measures of bone mineral density and strength in rodent models. Fewer data are available in humans, but data from growing children and postmenopausal women suggest that prebiotics have both short- and long-term effects that beneficially affect bone turnover and mineral accretion in the skeleton. Currently, the exact mechanism by which these products elicit their effects on bone is poorly understood, but emerging data suggest that the gut microbiota may be involved in one or more direct and indirect pathways. The most well-accepted mechanism is through microbial fermentation of prebiotics which results in the production of short-chain fatty acids and a concomitant decrease in pH which increases the bioavailability of calcium in the colon. While other mechanisms may be eliciting a prebiotic effect on bone, the current data suggest that novel dietary fibers may be an affordable and effective method of maximizing mineral accretion in growing children and preventing bone loss in later years when osteoporosis is a greater risk. This chapter will discuss the dynamic role of prebiotics in bone health by discussing the current state of the art, addressing gaps in knowledge and their role in public health.

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Effect of a combination GOS/FOS® prebiotic mixture and interaction with calcium intake on mineral absorption and bone parameters in growing rats

Abstract: Supplementing diets with the GOS/FOS(®) mixture increased bone mineralization, density and structure due to an increase in Ca, P and Mg absorptions. Thus, this prebiotic mixture may help to improve bone development in a period of high calcium requirements.

Cited by 55 publications

References 46 publications

Effect of a mixture of GOS/FOS® on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats

Effect of a mixture of GOS/FOS® on calcium absorption and retention during recovery from protein malnutrition: experimental model in growing rats

Immune Response of Fructo and Galacto‐Oligosaccharides

Prebiotics and Bone

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