Effect of a chelating drug on balance and tissue distribution of four essential metals

Physiological studies of some chelating agents in accumulation of some heavy metals in Tilapa florida

“…Analogues effects of ascorbic acid were reported by Calabrese and Kamp (1985). The present results seem to support the hypothesis that chelating agents may alter trace metal metabolism and are in general, consistent with those noted previously for other species (Torronen and marselos, 1978;Plana-Bohne, 1979;Milne and Omaye, 1980;Kostniak and Clarkson, 1981;Solecki et al, 1984;Tandon et al, 1984).…”

Effect of Some Chelating Agents on Balance and Tissue Distribution of Essential Trace Elements in Tilapia Florida

“…Analogues effects of ascorbic acid were reported by Calabrese and Kamp (1985). The present results seem to support the hypothesis that chelating agents may alter trace metal metabolism and are in general, consistent with those noted previously for other species (Torronen and marselos, 1978;Plana-Bohne, 1979;Milne and Omaye, 1980;Kostniak and Clarkson, 1981;Solecki et al, 1984 andTandon et al, 1984).…”

Antimycobacterial activity of rhodamine 3,4-HPO iron chelators against Mycobacterium avium: analysis of the contribution of functional groups and of chelator's combination with ethambutol

“…42,43 In addition, there are reports of the ability of ethambutol to chelate trace metals, namely iron and copper, This journal is © The Royal Society of Chemistry 2015 therefore contributing to a better control of the infection additionally to their usual described mechanism of action. [44][45][46] In this study we report the in vitro inhibitory effect of the new chelators and the in vitro inhibitory effect of MRH7, which proved to be the best performer of all four chelators studied by our group, when used in combination with ethambutol against M. avium. Taken together, our results suggest that the conjugation of hexadentate HPO iron chelators to a second bioactive molecule is a promising strategy against the microorganism M. avium and this work is the first report on the use of iron chelators in combination with other antibiotics for the treatment of M. avium infection.…”