Effect of a Calcium Carbonate-Based Dentifrice on in situ Enamel Remineralization

Cury, Jaime Aparecido; Simões, G.S.; Cury, Altair Antoninha Del Bel; Gonçalves, N.C.L.A.V.; Tabchoury, Cínthia Pereira Machado

doi:10.1159/000084807

Cited by 48 publications

(36 citation statements)

References 12 publications

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“…These calcium carbonate-based dentifrices, unique in Brazil, were tested in vitro (39) and in situ (40), and recently it was demonstrated that calcium carbonate might enhance the effect of fluoride present in the dentifrice (41), probably by its buffering properties and/or enhancement of calcium concentration in plaque (42). Irrespective of the abrasive used, Brazilian fluoride dentifrices have demonstrated ability to interfere with dental caries in in vitro (39,43) and in situ (40,44) studies.…”

Section: Role Of Fluoride Dentifricesmentioning

confidence: 99%

The importance of fluoride dentifrices to the current dental caries prevalence in Brazil

et al. 2004

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Similar to that which occurred in most developed countries, dental caries have shown a significant decline in Brazil over the last two decades. Water fluoridation, expansion of preventive programs at schools, and especially, the widespread use of fluoride dentifrice are discussed as factors related to this reduction in caries. Data from epidemiological surveys and historical facts are presented to support the importance of fluoride dentifrices to the current caries prevalence in Brazil.

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Section: Role Of Fluoride Dentifricesmentioning

confidence: 99%

The importance of fluoride dentifrices to the current dental caries prevalence in Brazil

et al. 2004

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“…Indeed, using this model it was possible to show the relationship between CaF 2 -like material formed on enamel by professional fluoride application, the release of F to the fluid phase of the test plaque and the consequent reduction of enamel demineralization . Also, this model was successfully used to evaluate the effect of a calcium abrasive-containing F dentifrice on enamel de-and remineralization [Cury et al, 2003[Cury et al, , 2005, and could be used to evaluate under controlled conditions the mechanisms of inhibition of enamel demineralization by F dentifrices.…”

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Mechanism of Fluoride Dentifrice Effect on Enamel Demineralization

et al. 2009

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Although the anticaries effect of fluoride (F) dentifrices is clearly established, the relative importance of F taken up by dental plaque not removed by brushing and of F products (CaF₂-like) formed on totally cleaned enamel for the subsequent inhibition of demineralization is not known. Both effects were evaluated using conventional (1,100 μg F/g) and low-F concentration (500 μg F/g) dentifrices in a randomized, crossover, double-blind in situ study. Enamel blocks not treated or pretreated with the dentifrices to form CaF₂-like deposits were mounted in palatal appliances in contact with a Streptococcus mutans test plaque. Volunteers brushed with non-F (negative control), low-F or conventional dentifrices and inserted the appliance in the mouth. F concentration in the fluid and solid phases of the test plaque was determined after 30 min, and a rinse with 20% sucrose solution was performed. After additional 45 min, plaque was collected and the loss of surface hardness at different test-plaque depths was measured. CaF₂-like deposition on enamel and F taken up by plaque due to the use of F dentifrices were able to significantly increase F concentration in the fluid phase of the test plaque, but only the latter significantly reduced the loss of hardness because of the 20–30 times higher F concentration. Also, significant differences between the low-F and conventional dentifrices were observed for F on enamel, in plaque and on the subsequent loss of hardness. The results suggest that uptake of F by dental plaque not removed by brushing may be the main cause of the anticaries effect of F dentifrices.

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“…This behavior becomes the surface hardness tests a valid option to evaluate the relationships between fluoride and enamel [23,24].…”

Section: Discussionmentioning

confidence: 99%

Effect of enamel pretreatment on the fluoride remineralization of artificial white spot lesions

Araújo

Lucena

Freitas

et al. 2018

BDS

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Ciência Odontológica Brasileira ReSumoObjetivos: A aplicação tópica de flúor é a principal estratégia para remineralizar lesões de mancha branca (MB). Foi proposto que o aumento na retenção deste íon na superfície pode favorecer a remineralização. Portanto, o tratamento prévio da superfície do esmalte foi proposto para otimizar sua eficácia. Material e Métodos: Este estudo objetivou avaliar a capacidade de remineralização do fluoreto com e sem pré-tratamento do esmalte com ácido fosfórico e nitrato de alumínio e a resistência do esmalte após novo desafio ácido. Vinte e quatro blocos de esmalte bovino foram obtidos e selecionados pela média inicial de microdureza de superfície (MS). Em seguida, MB foram artificialmente induzidas através de ciclagem DES-RE e os espécimes aleatorizados em dois grupos de acordo com o pré-tratamento do esmalte a ser avaliado (n=12): F (flúor gel acidulado 1,23% -APF -4 min) e P-Al-F (ácido fosfórico 37% -30s + nitrato de alumínio 0,05M 1min + APF por 4 min). Após o tratamento, um novo desafio ácido semelhante ao inicial foi realizado. Novas avaliações de MS foram obtidas em cada etapa. Os valores foram processados e a porcentagem de perda mineral da superfície (%PDS) foi obtida. Os dados foram analisados estatisticamente por ANOVA dois critérios e teste de Tukey (p<0,05). Resultados: Não houveram diferenças entre os protocolos avaliados. Para ambos grupos, uma diferença significante entre as fases do estudo foi detectada: observouse uma queda no %PDS após o tratamento e aumento do %PDS após novo desafio ácido. Conclusão: O pré-tratamento do esmalte com ácido fosfórico associado com nitrato de alumínio promoveu efeito similar à aplicação isolada do APF na remineralização das MB artificiais, recuperando parcialmente a dureza de superfície. Após o novo desafio ácido, os dois grupos ofereceram resistência parcial. PAlAvRAS-ChAveCáries dental; Esmalte dentário; Fluoreto; Remineralização dentária. ABSTRACTObjective: The topical fluoride application is the main strategy to remineralize white spots lesions (WSL). It is assumed that increasing its retention in the surface can favor remineralization. Therefore, previous treatments of the enamel surface are purposed to optimize its efficacy. This study aimed to evaluate the remineralization capacity of the fluoride without and with the pre-treatment of the enamel with phosphoric acid and aluminum nitrate and then, the enamel acid-resistance after new acid challenge. Material and Methods: Twenty-four enamel bovine blocks were obtained and selected by means of initial surface microhardness (SMH) measurements. In sequence, WSL were artificially inducted by DE-RE cycling and randomized in two groups according to the enamel pretreatment to be tested (n=12): F (1.23% fluoride gel -APF-4min) and P-Al-F (37% phosphoric acid-30s + 0.05M aluminum nitrate 1min + APF-4min). After then, a new acid challenge was equally performed. Additional SMH assessments were performed in each step. The values were processed and the percentage of SH loss (%SHL) was obtain...

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Effect of a Calcium Carbonate-Based Dentifrice on in situ Enamel Remineralization

Cited by 48 publications

References 12 publications

The importance of fluoride dentifrices to the current dental caries prevalence in Brazil

The importance of fluoride dentifrices to the current dental caries prevalence in Brazil

Mechanism of Fluoride Dentifrice Effect on Enamel Demineralization

Effect of enamel pretreatment on the fluoride remineralization of artificial white spot lesions

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