Effect of a 50 Hz electric field on plasma ACTH, glucose, lactate, and pyruvate levels in stressed rats

Harakawa, Shinji; Takahashi, Ikuo; Doge, Fuyuki; Martin, David E.

doi:10.1002/bem.10202

Cited by 34 publications

(52 citation statements)

References 10 publications

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“…And in accordance to Martí, Armario (1997), repeated stress is associated with the sensitivity of glucose, inducing hyperglycaemia. In accordance with Harakawa et al (2004), EMF of 50 Hz increases ACTH, glucose, lactate, and pyruvate levels in stressed rats, demonstrating that the 50 Hz EMF alters both stress responses and energy metabolism in stressed rats.…”

Section: Effects Of Undernutrition and Emf In The Cortisol Serum Concsupporting

confidence: 67%

Effects of the Electromagnetic field, 60 Hz, 3 µT, on the hormonal and metabolic regulation of undernourished pregnant rats

2009

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Epidemiological studies have implicated maternal protein-calorie deficiency as an important public health problem in developing countries. Over the last decades, a remarkable diffusion of electricity and an increased level of the electromagnetic field (EMF) in the environment have characterized modern societies. Therefore, researchers are concerned with the biological effects of 50-60 Hz, EMF. The aim of this paper is to show the effects of EMF of 60 Hz, 3 µT, exposure for two hours per day in the regulation of the hormonal and metabolic concentrations in pregnant rats, which were fed by Regional Basic Diet (RBD) during their pregnancy as compared with pregnant rats fed a standard diet. Pregnant rats exposed to EMF of 60 Hz, 3 µT, over the pregnancy and fed with RBD presented an increase in glucose release when compared with the Group subjected only to the RBD ration. Rats fed RBD presented a decrease in their insulin and cortisol serum levels when compared with the Group fed with casein. The T 3 and T 4 concentrations presented the greatest variation among the Groups. The relation T 4 :T 3 was much exaggerated in the Group subjected to RDB and exposed to EMF when compared to the others. In conclusion, the group subjected to the association of EMF and undernutrition suffered a decrease in its serum concentration of T 4 and T 3 when compared to the well-nourished group and the relationship T 4 :T 3 in the former group was almost eighteen-fold the later one.Keywords: casein, electromagnetic field, metabolism, hormone, regional basic diet, undernourished pregnant rats. Efeitos do campo eletromagnético, 60 Hz, 3µT, na regulação hormonal e metabólica de ratas prenhes desnutridas ResumoEstudos epidemiológicos têm mostrado que a deficiência proteico-calórica é um importante problema nos países em desenvolvimento. Durante as últimas décadas, a sociedade moderna tem sido caracterizada pelo aumento no número de equipamentos elétricos e como consequência um aumento no nível do campo eletromagnético (CEM) no ambiente. No entanto, os pesquisadores estão preocupados com os efeitos biológicos dos CEM de 50-60 Hz. O objetivo deste artigo é mostrar os efeitos do CEM de 60 Hz, 3 µT, nas concentrações hormonais e metabólicas de ratas prenhes, expostas duas horas por dia ao CEM, alimentadas pela Dieta Básica Regional (DBR) comparando com ratas submetidas às mesmas condições, mas alimentas com dieta padrão. Ratas prenhes expostas ao CEM de 60 Hz, 3 µT, durante a prenhez e alimentadas com a DBR apresentaram um aumento na liberação de glicose quando comparadas com o grupo alimentado pela DBR sem CEM. As ratas alimentadas pela DBR apresentaram uma diminuição nos níveis de insulina e cortisol quando comparadas com o grupo alimentado pela caseína. As concentrações de T 3 e T 4 apresentaram a maior variação entre os grupos. A relação T 4 :T 3 foi muito exagerada no grupo alimentado pela DBR e exposto ao CEM quando comparado com os outros. Conclusão, os animais que foram submetidos à desnutrição e ao CEM sofreram uma diminuição na ...

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Section: Effects Of Undernutrition and Emf In The Cortisol Serum Concsupporting

confidence: 67%

Effects of the Electromagnetic field, 60 Hz, 3 µT, on the hormonal and metabolic regulation of undernourished pregnant rats

2009

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“…1) [6]. The exposure cage was comprised of a cylindrical plastic cage (diameter; 200 mm, height; 200 mm) and two electrodes made of stainless steel (400 × 4 0 0 m m ) w e r e p l a c e d o ve r a n d u n d e r t h e cylindrical cage (Fig.…”

Section: Electric Field Exposure Systemmentioning

confidence: 99%

“…Furthermore, we have reported that exposure of restrained rats to an electric field suppressed increases in plasma ACTH, glucose and lactate levels induced by the restraint stress [6]. Although the biological effects of electric field exposure on reproductive function have not been fully identified yet, it has been reported that exposure of mice to magnetic fields had no adverse effects on fertility and reproduction [7,8].…”

mentioning

confidence: 96%

Exposure of C57BL/6J Male Mice to an Electric Field Improves Copulation Rates with Superovulated Females

et al. 2005

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Abstract. It is well-known that there are considerable strain differences in the relative copulation rates between male and superovulated female mice. In particular, the C57BL/6J strain of mice has a lower rate of successful copulation. We examined the effect of exposure to an electric field on sexual behavior in C57BL/6J male mice. When C57BL/6J males were exposed to a 50 Hz, 45 kV/m electric field for 30 min per day for 11 days and placed in a cage with a superovulated female of the same strain, the successful copulation rates of males was significantly improved compared with unexposed males (P<0.05). These results suggest that the exposure of C57BL/6J male mice to an electric field improves their sub-fertility activity in mating with superovulated females.

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“…Udincew et al [11] observed an increase of 11-OKS to 94% in serum and by 40% in the hormones excreting organs. In contrast, Harakawa et al [12] and Hedges-Dawson et al [13] noted a decrease of the cortisol hormone; however, this decrease occurred some days after (long-term application in rats), which the authors explained as exhaustion of the pituitary-adrenal system due to the longterm exposure [14,15]. Bonhomme-Faivre et al [16] describe decreased changes in the white cells system (neutropenia) in mice exposed to a magnetic field of 5μT induction resulting in a decrease of cortisol concentration on the 190th day of research.…”

Section: Discussionmentioning

confidence: 88%

The influence of the low-frequency magnetic fields of different parameters on the secretion of cortisol in men

Woldańska-Okońska¹,

Czernicki²,

Karasek³

2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: The aim of this paper is to test the influence of long-term application of the low-frequency magnetic fields in magnetotherapy and magnetostimulation on cortisol secretion in men. Materials and Methods: Patients were divided into three groups: 16 men underwent magnetotherapy and 20 men (divided into two groups) underwent magnetostimulation. Magnetotherapy -2 mT induction, 40 Hz, bipolar square wave, was applied for 20 min to lumbar area. Magnetostimulation (Viofor Jaroszyk, Paluszak, Sieroń (JPS) system, M2P2 program) was applied to 10 patients for 12 min each day. The third group (10 patients) underwent magnetostimulation (Viofor JPS system, M3P3) for 12 min each day using a different machine. All groups had 15 rounds of applications at approximately 10:00 a.m. with intermissions on the weekends. Blood serum was taken four times in a 24-hour period, before applications, the day after applications and a month later. Chemiluminescence micromethod was used to indicate hormone concentrations. Data was statistically analyzed with the analysis of variance (ANOVA) method. Results: The statistically significant gains in the circadian cortisol profile at 4:00 p.m., before and after application, were observed as a decrease in concentration during magnetotherapy. In magnetostimulation, with the M2P2 program, a significant increase in the cortisol concentration was observed in circadian profile at 12:00 p.m. one month after the last application. After magnetostimulation with the M3P3 program, a significant increase in concentration at 6:00 a.m. and a decrease in concentration at 12:00 p.m. were observed one month later. Statistically significant difference was demonstrated in the participants after the application of magnetotherapy and magnetostimulation with M3P3 program compared to the men submitted to magnetostimulation, with M2P2 program, at 4:00 p.m. after 15 applications. Conclusions: Biological hysteresis one month after magnetostimulation suggests long-term influence on the hypothalamohypophysial axis. The circadian curves of cortisol secretion a day after magnetotherapy and magnetostimulation with M3P3 program compared to magnetostimulation with M2P2 progam differs nearly by 100%, which proves that they show varied influence on cortisol secretion in men. All changes in the hormone concentration did not exceed the physiological standards of cortisol secretion, which suggests a regulating influence of magnetic fields on cortisol concentration rather than a strong stressogenic impact of magnetostimulation.

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Effect of a 50 Hz electric field on plasma ACTH, glucose, lactate, and pyruvate levels in stressed rats

Cited by 34 publications

References 10 publications

Effects of the Electromagnetic field, 60 Hz, 3 µT, on the hormonal and metabolic regulation of undernourished pregnant rats

Effects of the Electromagnetic field, 60 Hz, 3 µT, on the hormonal and metabolic regulation of undernourished pregnant rats

Exposure of C57BL/6J Male Mice to an Electric Field Improves Copulation Rates with Superovulated Females

The influence of the low-frequency magnetic fields of different parameters on the secretion of cortisol in men

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