Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans

Leal-Junior, Ernesto César Pinto; Lopes-Martins, Rodrigo Álvaro Brandão; Vanin, Adriane Aver; Baroni, Bruno Manfredini; Grosselli, Douglas; Marchi, Thiago De; Iversen, Vegard Vereide; Bjordal, Jan Magnus

doi:10.1007/s10103-008-0592-9

Cited by 141 publications

(133 citation statements)

References 26 publications

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“…Previous studies have used light therapy for muscular preconditioning by delivering the light therapy over the target muscles 5 min before fatigue tests in vivo [27,28] or in clinical trials [20][21][22]. These studies reported an increased number of repetitions and consequently a better fatigue-muscle resistance.…”

Section: Discussionmentioning

confidence: 99%

“…A study with a larger number of animals would be necessary to provide the statistical power to prove this difference. Possibly, the use of a t test between LEDT-sham and LEDT-5 min groups could show a statistically significant difference, such as has been reported in previous studies involving LLLT and muscular pre-conditioning [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…These reports have found good effects with this regimen of light therapy in muscular pre-conditioning, preventing muscle damage, and increasing the number of repetitions in fatigue tests. However, the majority of these results have only reported a small improvement compared to control groups, mainly measuring the number of repetitions in fatigue tests [20][21][22]. There may be a lack of understanding of the time response of muscles to light therapy and uncertainty about the best time to apply the light for optimal fatigue-muscle resistance in exercise until exhaustion.…”

Section: Introductionmentioning

confidence: 99%

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Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

et al. 2015

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Recently, low-level laser (light) therapy has been used to increase muscle performance in intense exercises. However, there is a lack of understanding of the time response of muscles to light therapy. The first purpose of this study was to determine the time response for light-emitting diode therapy (LEDT)-mediated increase in adenosine triphosphate (ATP) in the soleus and gastrocnemius muscles in mice. Second purpose was to test whether LEDT can increase the resistance of muscles to fatigue during intense exercise. Fifty male Balb/c mice were randomly allocated into two equal groups: LEDT-ATP and LEDT-fatigue. Both groups were subdivided into five equal subgroups: LEDT-sham, LEDT-5 min, LEDT-3 h, LEDT-6 h, and LEDT-24 h. Each subgroup was analyzed for muscle ATP content or fatigue at specified time after LEDT. The fatigue test was performed by mice repeatedly climbing an inclined ladder bearing a load of 150 % of body weight until exhaustion. LEDT used a cluster of LEDs with 20 red (630± 10 nm, 25 mW) and 20 infrared (850±20 nm, 50 mW) delivering 80 mW/cm 2 for 90 s (7.2 J/cm 2 ) applied to legs, gluteus, and lower back muscles. LEDT-6 h was the subgroup with the highest ATP content in soleus and gastrocnemius compared to all subgroups (P<0.001). In addition, mice in LEDT-6 h group performed more repetitions in the fatigue test (P<0.001) compared to all subgroups: LEDT-sham and LEDT-5 min (~600 %), LEDT-3 h (~200 %), and LEDT-24 h (~300 %). A high correlation between the fatigue test repetitions and the ATP content in soleus (r=0.84) and gastrocnemius (r=0.94) muscles was observed. LEDT increased ATP content in muscles and fatigue resistance in mice with a peak at 6 h. Although the time response in mice and humans is not the same, athletes might consider applying LEDT at 6 h before competition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

et al. 2015

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“…LLLT has been proved to simulate tissue chromophores and an increase in blood flow, inducing electronically excited states that modify their redox potential and catalytic activity [12]. E. C. Leal Junior et al also found that LLLT seemed to attenuate skeletal muscle fatigue and to reduce the muscle damage caused by titanic contractions induced by electrical stimulation [36]. Passarella et al found that laser irradiation generates an extra electrochemical potential and an increase of ATP synthesis inside the isolated mitochondria when compared with a non-irradiated control group [37].…”

Section: Resultsmentioning

confidence: 99%

Optical Spectroscopic Analysis of Muscle Spasticity for Low-Level Laser Therapy (LLLT)

Lee¹,

Lee²,

Youn³

2011

Journal of the Optical Society of Korea

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Current therapeutic methods for suppressing muscle spasticity are intensive functional training, surgery, or pharmacological interventions. However, these methods have not been fully supported by confirmed efficacy due to the aggravation of the muscle spasticity in some patients. In this study, a combined system was developed to treat with a low-level laser and to monitor the region of the treatment using an optical spectroscopic probe that measures oxygen saturation and deoxygenation during low-level laser therapy (LLLT). The evaluation of the wavelength dependence for LLLT was performed using a Monte Carlo simulation and the results showed that the greatest amount of heat generation was seen in the deep tissue at λ = 830 nm. In the oxy-and deoxygenation measurements during and after the treatment, oxygen-Hb concentration was significantly increased in the laser-irradiated group when compared to the control group. These findings suggest that LLLT using λ = 830 nm may be of benefit in accelerating recovery of muscle spasticity. The combined system that we have developed can monitor the physiological condition of muscle spasticity during the laser treatment in real time and may also be applied to various myotonia conditions such as muscle fatigue, back-pain treatment/monitoring, and ulcer due to paralysis.

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“…5 Recently, photobiomodulation therapy (PBMT) using low-level lasers or light-emitting diodes (LEDs) has been described as an electrophysical intervention that provides beneficial effects on muscular activity. [6][7][8] Researchers studying the application of PBMT before high-intensity exercises 9 have shown an increase in blood-lactate removal and a reduction in muscle injuries resulting in faster muscle recovery, 10,11 increased mitochondrial function through the modulation of cytochrome c oxidase, 12 and changes in the ionic gradient. 13 In many studies, [14][15][16] PBMT has been used as a noninvasive therapeutic modality to optimize vasodilation, improve collateral circulation, increase tissue oxygen levels, and enhance mitochondrial adenosine triphosphate levels.…”

mentioning

confidence: 99%

Using Pre-Exercise Photobiomodulation Therapy Combining Super-Pulsed Lasers and Light-Emitting Diodes to Improve Performance in Progressive Cardiopulmonary Exercise Tests

Miranda

Vanin

Tomazoni

et al. 2016

Journal of Athletic Training

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Context: Skeletal muscle fatigue and exercise performance are novel areas of research and clinical application in the photobiomodulation field, and positive outcomes have been reported in several studies; however, the optimal measures have not been fully established.Objective: To assess the acute effect of photobiomodulation therapy (PBMT) combining superpulsed lasers (low-level laser therapy) and light-emitting diodes (LEDs) on muscle performance during a progressive cardiopulmonary treadmill exercise test.Design: Crossover study. Setting: Laboratory. Patients or Other Participants: Twenty untrained male volunteers (age ¼ 26.0 6 6.0 years, height ¼ 175.0 6 10.0 cm, mass ¼ 74.8 6 10.9 kg).Intervention(s): Participants received PBMT with either combined superpulsed lasers and LED (active PBMT) or placebo at session 1 and the other treatment at session 2. All participants completed a cardiopulmonary test on a treadmill after each treatment. For active PBMT, we performed the irradiation at 17 sites on each lower limb (9 on the quadriceps, 6 on the hamstrings, and 2 on the gastrocnemius muscles), using a cluster with 12 diodes (four 905-nm superpulsed laser diodes with an average power of 0.3125 mW, peak power of 12.5 W for each diode, and frequency of 250 Hz; four 875-nm infrared LED diodes with an average power of 17.5 mW; and four 640-nm red LED diodes with an average power of 15 mW) and delivering a dose of 30 J per site.Main Outcome Measure(s): Distance covered, time until exhaustion, pulmonary ventilation, and dyspnea score.Results: The distance covered (1.96 6 0.30 versus 1.84 6 0.40 km, t 19 ¼ 2.119, P , .001) and time until exhaustion on the cardiopulmonary test (780.2 6 91.0 versus 742.1 6 94.0 seconds, t 19 ¼ 3.028, P , .001) was greater after active PBMT than after placebo. Pulmonary ventilation was greater (76.4 6 21.9 versus 74.3 6 19.8 L/min, t 19 ¼ 0.180, P ¼ .004) and the score for dyspnea was lower (3.0 [interquartile range ¼ 0.5-9.0] versus 4.0 [0.0-9.0], U ¼ 184.000, P , .001) after active PBMT than after placebo.Conclusions: The combination of lasers and LEDs increased the time, distance, and pulmonary ventilation and decreased the score of dyspnea during a cardiopulmonary test. Key Words: low-level laser therapy, light-emitting diode therapy, fatigue, progressive-intensity exercise Key PointsPhotobiomodulation therapy combines the use of superpulsed lasers and light-emitting diodes. When applied before a progressive cardiopulmonary exercise test on a treadmill, photobiomodulation therapy increased distance covered, time to exhaustion, and pulmonary ventilation and decreased dyspnea sensation in healthy volunteers.

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Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans

Cited by 141 publications

References 26 publications

Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice

Optical Spectroscopic Analysis of Muscle Spasticity for Low-Level Laser Therapy (LLLT)

Using Pre-Exercise Photobiomodulation Therapy Combining Super-Pulsed Lasers and Light-Emitting Diodes to Improve Performance in Progressive Cardiopulmonary Exercise Tests

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