Effect of 8-weeks prebiotics/probiotics supplementation on alcohol metabolism and blood biomarkers of healthy adults: a pilot study

Irwin, Christopher; Khalesi, Saman; Cox, Amanda J.; Grant, Gary; Davey, Andrew K.; Bulmer, Andrew Cameron; Desbrow, Ben

doi:10.1007/s00394-017-1437-8

Cited by 19 publications

(12 citation statements)

References 50 publications

(38 reference statements)

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“…Seven studies also reported changes in fasting blood glucose (FBG) and insulin levels. Of these, four reported no significant changes in FBG or insulin levels (55,64,71,72), two reported reduction in FBG and insulin level (62,68) and one reported an increase in FBG after probiotics supplementation in healthy adults (65). Similar to BMI, the evidence is inconclusive for the beneficial effect of probiotics on FBG and insulin level in healthy adults.…”

Section: Immune System Responsementioning

confidence: 97%

“…However, these findings are in contrast with the results of several other studies indicating that probiotic supplementation had no influence on the incidence (47,48,50) or severity (47,48) Changes in BMI were reported in six studies (Table 3). Of these four reported no significant changes (18,55,67,71) and one reported a significant increase in BMI after probiotic supplementation (65). One of the studies assessed the BMI increase after four weeks of highfat diet and reported a lower increase in BMI in the probiotic group compared to placebo (72).…”

Section: Immune System Responsementioning

confidence: 99%

“…The ability of probiotics to impart health benefits has prompted increased scientific interest for several decades. Evidence from animal and human studies has demonstrated potentially favourable benefits of probiotics, including modulating the number and diversity of beneficial gut microbiota (5,6); reducing symptoms associated with various GI disorders (7,8); improving blood cholesterol levels and blood lipid profile (9,10); removal of mycotoxins (11); reducing blood pressure and hypertension (12); improving blood glucose tolerance and diabetes control (13,14); and enhancing mental state and cognitive function (15).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, conclusions regarding the influence of probiotics on the blood lipid profile of healthy adults cannot be reliably determined from this work.A summary of results from the present review of literature for the effect of probiotics consumption on blood lipid profile of healthy adults is presented inTable 3. Of the fourteen studies (fifteen trials, one study with two separate arms (61)), seven reported no significant changes in the concentration of various blood lipid profile markers following probiotics consumption(18,55,(61)(62)(63)(64)(65). Three studies reported a significant reduction in TC(61,(66)(67)(68).Reductions in TG (68-71), LDL-C (61, 66), and an increase in HDL-C (67, 68) were also reported.…”

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confidence: 99%

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A review of probiotic supplementation in healthy adults: helpful or hype?

et al. 2018

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Probiotic supplements have a positive impact on several health outcomes. However, the majority of published studies have focused on populations with specific health pathologies. Therefore, this study reviewed the current literature on the health effects of probiotic consumption in "healthy adults." The findings from this review may help guide consumers, researchers, and manufacturers regarding probiotic supplementation. Relevant literature published between 1990 and August 2017 was reviewed. Studies were included if they were experimental trials, included healthy adults, used live bacteria, and had accessible full-text articles published in English. Included studies were classified according to common foci that emerged. Forty-five studies were included in this review. Five foci emerged: gut microbiota changes (n = 15); immune system response (n = 16); lipid profile and cardiovascular disease risk (n = 14); gastrointestinal discomfort (n = 11); and female reproductive health (n = 4). Results suggest that probiotic supplementation in healthy adults can lead to transient improvement in gut microbiota concentration of supplement-specific bacteria. Evidence also supports the role of probiotics in improving immune system responses, stool consistency, bowel movement, and vaginal lactobacilli concentration. There is insufficient evidence to support the role of probiotics to improve blood lipid profile. Probiotic consumption can improve in the immune, gastrointestinal, and female reproductive health systems in healthy adults. However, this review failed to support the ability of probiotics to cause persistent changes in gut microbiota, or improve lipid profile in healthy adults. The feasibility of probiotics consumption to provide benefits in healthy adults requires further investigation.

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Section: Immune System Responsementioning

confidence: 97%

Section: Immune System Responsementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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A review of probiotic supplementation in healthy adults: helpful or hype?

et al. 2018

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“…There is increasing evidence for the health benefits of probiotics, including enhancement of the immune response (Khalesi et al, 2018), a protective role against allergy (Sharma and Im, 2018;Szari and Quinn, 2019), removal of chemical contaminants and ability to reduce the toxicity of contaminants (Feng et al, 2018;Wochner et al, 2018;Wang et al, 2019), improving intestinal health by modulating the number and diversity of beneficial gut microbiota, and reducing symptoms associated with various gastrointestinal disorders (Ferrario et al, 2014;Ford et al, 2014;Feng et al, 2018;Irwin et al, 2018;Vasquez et al, 2019), hepatoprotective effects (Meng et al, 2018), cardiovascular disease prevention by improving blood cholesterol levels and blood lipid profile, reducing blood pressure and hypertension (Guo et al, 2011;Khalesi et al, 2014;Sun and Buys, 2015;Vasquez et al, 2019), improving blood glucose tolerance and diabetes control (Sun and Buys, 2016;Plows et al, 2019), improved mental health (Inserra et al, 2018;Bruce-Keller et al, 2018;Dutta et al, 2019), and cancer prevention (Nazir et al, 2018;Scott et al, 2018;Ma et al, 2019). However, in order to improve the probability of these beneficial effects, probiotic candidate strains should be submitted to selection assays, which can be crucial to promulgate the therapeutic effect in the host.…”

Section: Benefits Of Probiotic Organismsmentioning

confidence: 99%

Research Article <i>Lactobacillus</i> <i>crispatus</i> protects against bacterial vaginosis

Almeida¹,

Carmo²,

Gala-García³

et al. 2019

Genet. Mol. Res.

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In medicine, the 20th century was marked by one of the most important revolutions in infectious-disease management, the discovery and increasing use of antibiotics. However, their indiscriminate use has led to the emergence of multidrug-resistant (MDR) bacteria. Drug resistance and other factors, such as the production of bacterial biofilms, have resulted in high recurrence rates of bacterial diseases. Bacterial vaginosis (BV) syndrome is the most prevalent vaginal condition in women of reproductive age, ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (4): gmr18475 M.O. Almeida et al. 2 leading to considerable discomfort. BV can be a consequence of gynecological and obstetric complications, as well as sexually transmitted diseases. Given the decrease in efficiency of antibiotic therapy and high rates of recurrence, probiotics have become promising alternatives for both prevention and treatment of BV, or as an adjuvant to conventional therapy. Currently, Lactobacillus species are the most extensively studied for use as probiotics. Probiotics act through stimulation of the host immune system, competitive exclusion and antimicrobial activity; the latter involves production of substances such as lactic acid, hydrogen peroxide and bacteriocins. Lactobacillus crispatus is considered to be a biomarker of a healthy vaginal tract and is indicated for a probiotic approach to maintaining and restoring of a healthy vaginal ecosystem. Some L. crispatus probiotic strains are already commercially available with encouraging results; however, control of BV syndrome still presents many challenges.

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