Effect of 6-OHDA on hypercapnic ventilatory response in the rat model of Parkinson’s disease

Andrzejewski, Kryspin; Budzinska, K.; Kaczyńska, Katarzyna

doi:10.33549/physiolres.933949

Cited by 11 publications

(16 citation statements)

References 47 publications

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“…In other studies, carried out by Andrzejewski and Budzinska, it was observed that animals that received 6-OHDA in the region of the medial forebrain bundle, representing mild cases of PD, presented an increase in VT and a reduction in fR under conditions of hypercapnia and hypoxia, maintaining a VE practically unchanged in the experimental animals (129,130). These findings in animal models reinforce the results found in patients with PD by Seccombe.…”

Section: Central Respiratory Disorderssupporting

confidence: 82%

Respiratory disorders of Parkinson’s disease

Aquino

Cabral

Miranda

et al. 2022

Journal of Neurophysiology

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Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, mainly affecting people over 60 years of age. Patients develop both classic symptoms (tremors, muscle rigidity, bradykinesia and postural instability) and nonclassical symptoms (orthostatic hypotension, neuropsychiatric deficiency, sleep disturbances and respiratory disorders). Thus, patients with PD can have a significantly impaired quality of life, especially when they do not have multi-modality therapeutic follow-up. The respiratory alterations associated with this syndrome are the main cause of mortality in PD. They can be classified as peripheral when caused by disorders of the upper airways or muscles involved in breathing and as central when triggered by functional deficits of important neurons located in the brainstem and involved in respiratory control. Currently, there is little research describing these disorders, and therefore, there is no well-established knowledge about the subject, making the treatment of patients with respiratory symptoms difficult. In this review, the history of the pathology and data about the respiratory changes in PD obtained thus far will be addressed.

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Section: Central Respiratory Disorderssupporting

confidence: 82%

Respiratory disorders of Parkinson’s disease

Aquino

Cabral

Miranda

et al. 2022

Journal of Neurophysiology

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“…Other neurotransmitter systems like serotonergic or noradrenergic have been postulated to contribute to respiratory PD abnormalities [8,12,[39][40][41].…”

Section: Discussionmentioning

confidence: 99%

“…Recent study performed in 6-OHDA-induced PD model demonstrated decrease in expression of neurokinin 1 receptor in the pre-Bötzinger Complex and phox2b-expressing neurons in retrotrapezoid nucleus corresponding with frequency of breathing decline in normoxic breathing and decreased tachypneic response to hypercapnia [8,10]. Our previous study in unilateral 6-OHDA model displayed increased tidal volume and attenuated respiratory rate responses during hypoxia and hypercapnia in comparison to sham-operated rats [11,12].…”

Section: Introductionmentioning

confidence: 85%

Respiratory pattern and phrenic and hypoglossal nerve activity during normoxia and hypoxia in 6-OHDA-induced bilateral model of Parkinson’s disease

et al. 2020

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Respiratory disturbances present in Parkinson's disease (PD) are not well understood. Thus, studies in animal models aimed to link brain dopamine (DA) deficits with respiratory impairment are needed. Adult Wistar rats were lesioned with injection of 6-hydroxydopamine (6-OHDA) into the third cerebral ventricle. Two weeks after hypoxic test was performed in whole-body plethysmography chamber, phrenic (PHR) and hypoglossal (HG) nerve activities were recorded in normoxic and hypoxic conditions in anesthetized, vagotomized, paralyzed and mechanically ventilated rats. The effects of activation and blockade of dopaminergic carotid body receptors were investigated during normoxia in anesthetized spontaneously breathing rats. 6-OHDA injection affected resting respiratory pattern in awake animals: an increase in tidal volume and a decrease in respiratory rate had no effect on minute ventilation. Hypoxia magnified the amplitude and minute activity of the PHR and HG nerve of 6-OHDA rats. The ratio of pre-inspiratory to inspiratory HG burst amplitude was reduced in normoxic breathing. Yet, the ratio of pre-inspiratory time to total time of the respiratory cycle was increased during normoxia. 6-OHDA lesion had no impact on DA and domperidone effects on the respiratory pattern, which indicate that peripheral DA receptors are not affected in this model. Analysis of monoamines confirmed substantial striatal depletion of dopamine, serotonin and noradrenaline (NA) and reduction of NA content in the brainstem. In bilateral 6-OHDA model changes in activity of both nerves: HG (linked with increased apnea episodes) and PHR are present. Demonstrated respiratory effects could be related to specific depletion of DA and NA.

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“…These changes in neuromediators concentrations could be responsible for the breathing changes observed in this model. As a possible mechanism of different modulation of phrenic and hypoglossal reactions, the authors suggest the involvement of a modified mechanism of dopamine efflux and of serotonin and orexin during hypoxia (Andrzejewski et al 2019).…”

Section: Lessons Learned From Animal Models Of Pdmentioning

confidence: 97%

Respiratory Function and Dysfunction in Parkinson-Type Neurodegeneration

Pokusa¹,

Hajduchova²,

Buday³

et al. 2020

Physiol Res

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Parkinson's disease (PD) is most commonly manifested by the presence of motor symptoms. However, non-motor symptoms occur several years before the onset of motor symptoms themselves. Hallmarks of dysfunction of the respiratory system are still outside the main focus of interest, whether by clinicians or scientists, despite their indisputable contribution to the morbidity and mortality of patients suffering from PD. In addition, many of the respiratory symptoms are already present in the early stages of the disease and efforts to utilize these parameters in the early diagnosis of PD are now intensifying. Mechanisms that lead to the development and progression of respiratory symptoms are only partially understood. This review focuses mainly on the comparison of respiratory problems observed in clinical studies with available findings obtained from experimental animal models. It also explains pathological changes observed in non-neuronal tissues in subjects with PD.

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Effect of 6-OHDA on hypercapnic ventilatory response in the rat model of Parkinson’s disease

Cited by 11 publications

References 47 publications

Respiratory disorders of Parkinson’s disease

Respiratory disorders of Parkinson’s disease

Respiratory pattern and phrenic and hypoglossal nerve activity during normoxia and hypoxia in 6-OHDA-induced bilateral model of Parkinson’s disease

Respiratory Function and Dysfunction in Parkinson-Type Neurodegeneration

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