Effect of 6-Mercaptopurine on Homograft Reaction in Rats

Enhanced Suppression of Experimental Allergic Encephalomyelitis by Combination Chemotherapy with Duazomycin-A and 6-Mercaptopurine

“…The differences between our study and that of Hoyer et d. probably reflect species differences in the response to, or the metabolism of, 6-MP; thus, in daily doses of 1 2 mg/kg, 6-MP was toxic to the rabbit and abolished all signs of EAE during drug administration, whereas daily doses up to 50 mg/kg for 15 days were nontoxic in the present study and complete suppression of clinical disease in all animals was not achieved. Other workers have also noted the relative resistance of rats to the toxic effects of 6-MP (23).…”

Inhibition by 6-Mercaptopurine of Polyarthritis induced by Freund's Adjuvant

“…There are numerous studies in the literature of the preventive effect of 6-mercaptopurine (6-MP) in the primary and secondary immune responses in skin and renal homografts, protein antigens, experimental allergic encephalomyelitis, and intramyocardial injections of streptococci (Schwartz, Stack, and Dameshek, 1958;Meeker, Condie, Weiner, Varco, and Good, 1959;Schwartz andDameshek, 1959, 1960;Schwartz, Eisner, and Dameshek, 1959;Calne, 1960;Hoyer, Condie, and Good, 1960;Thomas, Morton, Crane, and Gardner, 1961;Zukoski, Lee, and Hume, 1961;Pierce and Varco, 1962;Laufer, Ginsburg, Gery, and Davies, 1963).…”