Effect of 5% transdermal lidocaine patches on postoperative analgesia in dogs undergoing hemilaminectomy

Bravo, Verónica Re; Aprea, Francesco; Bhalla, Rebecca J.; Gennaro, Chiara De; Cherubini, Giunio Bruto; Corletto, Federico; Vettorato, Enzo

doi:10.1111/jsap.12925

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…All dogs in group CRI received a NSAID, while it was only administered to 78.5% of dogs in group ESPB. A lidocaine patch was applied to 51% of the dogs in the group CRI, but this should not have impacted our results as this technique did not provide any extra postoperative analgesia following hemilaminectomies in dogs [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Medical records were excluded if: the volume of the local anaesthetic used on each side for the ESPB was < 0.5 mL/kg; if fentanyl (Fentadon; Dechra Pharmaceuticals, UK) was not the only rescue analgesic drug used intraoperatively; if additional surgeries other than hemilaminectomy were performed; if the dog was scored 5 (paraplegia without deep pain) according to the modified Frankel score (MFS) [ 14 ]; if the dog experienced any possible adverse reaction to the drug used; if medical records were incomplete or data were missing. The control group (group CRI) was composed of 39 dogs that underwent hemilaminectomy between September 2014 and June 2017, and in which a fentanyl CRI (2 μg/kg bolus followed by 5 μg/kg/hour) was administered [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

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Analgesic efficacy of a bilateral erector spinae plane block versus a fentanyl constant rate infusion in dogs undergoing hemilaminectomy: a retrospective cohort study

Viilmann¹,

Drożdżyńska²,

Vettorato

2022

BMC Vet Res

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Background Erector spinae plane block (ESPB) is an ultrasound-guided interfascial plane block used to provide analgesia in dogs undergoing hemilaminectomy. The aim of this study is to compare the analgesic efficacy of a bilateral ESPB with a fentanyl constant rate infusion (CRI) in dogs undergoing hemilaminectomy. Methods This is a retrospective cohort study. Anaesthetic records of client-owned dogs undergoing hemilaminectomy (June 2019–August 2020), and in which a bilateral ESPB was performed (group ESPB), were retrieved and compared to a cohort of 39 dogs that underwent hemilaminectomy (September 2014 – June 2017) and in which a fentanyl CRI (2 μg/kg bolus followed by 5 μg/kg/hour) was used as a primary intraoperative analgesia (group CRI). The prevalence of dogs in which intraoperative rescue fentanyl boluses were administered, the total dose of rescue fentanyl boluses administered, the postoperative methadone requirement and anaesthetic complications during the first 24 postoperative hours were evaluated. Univariate statistical analysis was used. Results Group ESPB comprised of 93 dogs. The bilateral ESPB was performed using a median (range) levobupivacaine volume of 1 (0.5–1.7) mL/kg per side, at a concentration of 0.125% (0.12–0.25). At least one rescue fentanyl bolus was administered in 54.8% and in 56.4% of dogs in group ESPB and CRI, respectively (p > 0.99). The number of rescue fentanyl boluses was higher in group CRI (p = 0.006), especially during lumbar hemilaminectomy. Rescue fentanyl boluses were more frequently administered from skin incision to end of vertebral lamina drilling in group CRI (p = 0.001), and from end of vertebral lamina drilling to end of surgery in group ESPB (p = 0.0002). During the first 6 (p = 0.0035) and 6–12 (p = 0.0005) postoperative hours, the number of dogs that required at least one dose of methadone was higher in group CRI. In group ESPB, dogs were more likely to become hypothermic (p = 0.04). One dog, not included in the study, developed sinus arrest after performing a caudal thoracic ESPB. Conclusions Under the conditions of this study, a bilateral ESPB was associated with a lower number of rescue fentanyl boluses administered in dogs undergoing hemilaminectomy, especially between skin incision to end of vertebral lamina drilling. Despite ESPB being associated with a reduced opioid consumption during the first 12 hours postoperatively, differences in the postoperative management precluded any firm conclusion regarding its postoperative effect.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Analgesic efficacy of a bilateral erector spinae plane block versus a fentanyl constant rate infusion in dogs undergoing hemilaminectomy: a retrospective cohort study

Viilmann¹,

Drożdżyńska²,

Vettorato

2022

BMC Vet Res

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“…The CMPS-SF is a four-section checklist, based on visual assessments and wound palpation. Since the mobility section of the original scale could not be carried out, the maximum score on this scale was 20, as already mentioned by Schmierer et al (2020) and Re Bravo et al (2018).…”

Section: Methodsmentioning

confidence: 99%

“…There is still no consensus on which drug or protocol is the most effective for the postoperative analgesia in dogs undergoing spinal procedures, since both opioids and nonopioids drugs (non-opioid analgesics, NSAIDs, gabapentin, pregabalin, methocarbamol, medetomidine, diazepam, lidocaine) have already been described for this purpose (Forterre et al 2008, Aghighi et al 2012, Barker et al 2013, Taylor-Brown et al 2015, Giudice et al 2017, Re Bravo et al 2018, Ripplinger et al 2018, Schmierer et al 2020.…”

Section: Introductionmentioning

confidence: 99%

The need for opioid in the postoperative analgesia of dogs undergoing hemilaminectomy due to intervertebral disc extrusion

et al. 2021

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The aim of this study was to evaluate the postoperative analgesic effect of protocols with and without the opioid methadone in dogs with intervertebral disc extrusion undergoing decompressive surgery. Sixteen paraplegic dogs with preserved nociception underwent hemilaminectomy/disc fenestration and were randomly assigned to two groups. The analgesic protocol consisted of methadone, meloxicam and dipyrone in Group I (G1), and meloxicam and dipyrone in Group II (G2). The animals were blindly assessed by two observers, using the visual analogue scale (VAS) and the short-form Glasgow Composite Measure Pain Scale (CMPS-SF). Assessments occurred every 2 hours during first 24 hours post-surgery, and every 4 hours afterwards. There was no statistical difference among groups regarding pain scores or analgesic rescues. Both analgesic protocols provided analgesia in the initial 48 hours postoperatively, demonstrating that opioids are not necessary in the postoperative period of dogs undergoing hemilaminectomy and disc fenestration.

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“…Outra possibilidade de produto com administração tópica de uso recente na medicina veterinária são os patches de lidocaína, aprovados em 1999 em humanos para tratamento de dor neuropática (Ko et al, 2008). Os patches transdérmicos de lidocaína são adesivos medicamentosos que possuem comprovada absorção sistêmica mínima no homem e oferecem diversos benefícios, incluindo um risco mínimo de interação com outros drogas e quase nenhum efeito colateral induzido pela absorção sistêmica (Weiland et al, 2006;Re Bravo et al, 2019). Já tiveram utilização relatada em diversas espécies, como caninos, felinos e equinos, com diferentes aplicações (Grimm et al, 2015).…”

Section: Anestesia Tópica Ou Anestesia De Superfícieunclassified

Anestesia local associada a biopsias cutâneas na medicina veterinária: uma revisão narrativa

Santos

Silva²,

Ledur³

et al. 2022

RSD

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Biópsias cutâneas, especialmente por punch, são amplamente utilizadas como ferramenta diagnóstica na dermatologia veterinária. Esse procedimento pode ser realizado com anestesia geral aliada ou não a anestesia local, e em alguns casos, com anestesia local isoladamente. A lidocaína é o anestésico local mais utilizado, devido a sua rápida ação, fácil acesso e relativo baixo custo. A anestesia infiltrativa é normalmente utilizada em procedimentos dermatológicos, mas anestesia regional e anestesia tópica também podem ser recomendadas em alguns casos. Efeitos adversos variam de incomuns a raros, e incluem reações locais, de lesões nervosas locais e hipersensibilidade ou dermatite de contato, e reações sistêmicas como anafilaxia, cardiotoxicidade e depressão do sistema nervoso central. Quando administrados na dose adequada para a espécie referida, com técnica padronizada e conhecimento anatômico, as reações adversas são extremamente raras. Anestésicos locais são de importância fundamental para a dermatologia veterinária, principalmente em biópsias de pele de cães e gatos. O objetivo desta revisão narrativa é explorar a estrutura e mecanismo de ação dos principais fármacos utilizados, técnicas de anestesia local, assim como possíveis efeitos adversos associados à utilização destes fármacos em cirurgias dermatológicas, com ênfase em biópsias cutâneas.

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Effect of 5% transdermal lidocaine patches on postoperative analgesia in dogs undergoing hemilaminectomy

Abstract: In this setting, 5% lidocaine patches did not provide additional postoperative analgesia in dogs undergoing hemilaminectomy.

Cited by 5 publications

References 36 publications

Analgesic efficacy of a bilateral erector spinae plane block versus a fentanyl constant rate infusion in dogs undergoing hemilaminectomy: a retrospective cohort study

Analgesic efficacy of a bilateral erector spinae plane block versus a fentanyl constant rate infusion in dogs undergoing hemilaminectomy: a retrospective cohort study

The need for opioid in the postoperative analgesia of dogs undergoing hemilaminectomy due to intervertebral disc extrusion

Anestesia local associada a biopsias cutâneas na medicina veterinária: uma revisão narrativa

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