Effect of 5′-deoxy-5′-S-isobutyl-adenosine (siba) on mouse mammary tumour cells and on the expression of mouse mammary tumour virus

Terrioux, C.; Crépin, Michel; Gros, François; Robert-Géro, Malka; Lederer, E.

doi:10.1016/0006-291x(78)91042-2

Cited by 12 publications

(2 citation statements)

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“…Ara-A (Shannon et al, 1974), tubercidin, neplanocin A, SIBA (Terrioux et al , 1978), 5'-dimethylaminoethyl-S-5'-deoxyadenosine (Shire et al, 1980) and (8-DHPA (Kara et al, 1979), we could not detect any significant protective effects on the survival and growth of ATH 8 cells.…”

Section: Inhibition Of the Cytopathic Effect Of Htly-iii/lav On Ath 8contrasting

confidence: 55%

“…Among a series of adenosine analogues, most of which were previously shown inhibitory to transformation of mammalian cells by retroviruses, i,e. Ara-A (Shannon et al, 1974), tubercidin, neplanocin A, SIBA (Terrioux et al , 1978), 5'-dimethylaminoethyl-S-5'-deoxyadenosine (Shire et al, 1980) and (8-DHPA (Kara et al, 1979), we could not detect any significant protective effects on the survival and growth of ATH 8 cells.…”

Section: Effect Of Suramin Derivatives On (Moloney) Murine Leukemia Vmentioning

confidence: 55%

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Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T‐cell lymphotropic virus (HTLV‐III)/lymphadenopathy‐associated virus (LAV)

Balzarini

Mitsuya

Clercq

et al. 1986

Intl Journal of Cancer

103

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Suramin and various other selected compounds were evaluated for their in vitro inhibitory effects on the infectivity and replication of human T-cell lymphotropic virus (HTLV/III)/lymphadenopathy-associated virus (LAV). As parameters for infectivity and replication, respectively, we followed the cytopathic effect of HTLV-III/LAV on ATH 8 cells, a T-cell clone with high susceptibility to HTLV-III/LAV, and the expression of HTLV-III/LAV p24 gag protein in H9 cells infected with HTLV-III/LAV. As the most effective inhibitors of HTLV-III/LAV the following substances emerged (in order of decreasing activity): Evans Blue approximately equal to suramin greater than phosphonoformic acid greater than Direct Yellow 50. Several purine nucleoside analogues including vidarabine, tubercidin, neplanocin A, dihydroxypropyladenine, pyrazofurin and ribavirin were not inhibitory to HTLV-III/LAV. In our test systems, involving a high multiplicity of infection, HPA-23, previously reported to be effective against LAV reverse transcriptase, showed no inhibitory effect on HTLV-III/LAV infectivity for ATH 8 cells and proved only weakly inhibitory to HTLV-III/LAV replication in H9 cells. Thus, among the anionic dyes that are structurally related to suramin, compounds were found which were as active as suramin itself, if not more so.

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Section: Inhibition Of the Cytopathic Effect Of Htly-iii/lav On Ath 8contrasting

confidence: 55%

Section: Effect Of Suramin Derivatives On (Moloney) Murine Leukemia Vmentioning

confidence: 55%