Effect of 4G-α-glucopyranosyl hesperidin on brown fat adipose tissue- and cutaneous-sympathetic nerve activity and peripheral body temperature

Shen, Jiao; Nakamura, Hiroyasu; Fujisaki, Yoshiyuki; Tanida, Mamoru; Horii, Yuko; Fuyuki, Risa; Takumi, Hiroko; Shiraishi, Koso; Kometani, Takashi; Nonomura, Katsuya

doi:10.1016/j.neulet.2009.05.067

Cited by 23 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found in our previous study 17) that an oral administration of G-Hsp increased the interscapular brown adipose tissue-sympathetic nerve activity (BAT-SNA), but decreased the cutaneous sympathetic nerve activity (CASNA) in urethane-anesthetized rats. We assessed in the present study the effects of an oral administration of G-Hsp on the autonomic nervous system in humans.…”

Section: Discussionmentioning

confidence: 91%

“…The hesperetin concentration in serum after hydrolyzing the glucuronide and sulfate conjugates is sufficient for favorable biological effects in cell and animal studies. 13) We found in our previous study 17) that an oral administration of G-Hsp increased the interscapular brown adipose tissue-sympathetic nerve activity (BAT-SNA), but decreased the cutaneous sympathetic nerve activity (CASNA) in urethane-anesthetized rats. Predictably, we observed that the subcutaneous body temperature (BT) at the caudal end of the back after an oral administration of G-Hsp was significantly higher than subcutaneous BT after an oral administration of water in conscious rats.…”

mentioning

confidence: 90%

See 1 more Smart Citation

Effects of α-Glucosylhesperidin on the Peripheral Body Temperature and Autonomic Nervous System

Takumi¹,

Fujishima²,

Shiraishi³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 90%

Effects of α-Glucosylhesperidin on the Peripheral Body Temperature and Autonomic Nervous System

Takumi¹,

Fujishima²,

Shiraishi³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

Self Cite

View full text Add to dashboard Cite

“…WD-Hpt was diluted with sterilized water and injected intraperitoneally 30 min before the surgery and again once daily (0.3 ml, 200 mg/kg/day) until sacrifice. The dose of WD-Hpt was determined by following a previous study [27]. The other mice received normal saline (NS, 0.3 ml) as control.…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury

et al. 2015

Self Cite

View full text Add to dashboard Cite

Purpose To determine whether water-dispersible hesperetin (WD-Hpt) can prevent degeneration of ganglion cell neurons in the ischemic retina. Methods Ischemia reperfusion (I/R) injury was induced by increasing the intraocular pressure of mice to 110 mmHg for 40 min. Mice received daily intraperitoneal injections with either normal saline (NS, 0.3 ml/day) or WD-Hpt (0.3 ml, 200 mg/kg/day). Reactive oxygen species (ROS) was assessed by dihydroethidium and nitrotyrosine formation. Inflammation was estimated by microglial morphology in the retina. Lipopolysaccharide (LPS)-stimulated BV-2 cells were used to explore the anti-inflammatory effect of WD-Hpt on activated microglia by quantifying the expression of IL-1β using real-time quantitative reverse transcription-polymerase chain reaction. Ganglion cell loss was assessed by immunohistochemistry of NeuN. Glial activation was quantified with glial fibrillary acidic protein (GFAP) immunoreactivity. Apoptosis was evaluated with a terminal deoxynucleotidyl transferase (TUNEL) assay and immunohistochemistry of cleaved caspase-3. Phosphorylation of extracellular signal-regulated kinase (p-ERK) was surveyed by western blotting. Results WD-Hpt decreased I/R-induced ROS formation. WD-Hpt alleviated microglial activation induced by I/R and reduced mRNA levels of IL-1β in LPS-stimulated BV-2. I/R resulted in a 37 % reduction in the number of ganglion cells in the NS-treated mice, whereas the reduction was only 5 % in the WD-Hpt-treated mice. In addition, WD-Hpt mitigated the immunoreactivity of GFAP, increased expression of cleaved caspase-3, increased number of TUNEL positive cells and p-ERK after I/R. Conclusions WD-Hpt protected ganglion cells from I/R injury by inhibiting oxidative stress and modulating cell death signaling. Moreover, WD-Hpt had an anti-inflammatory effect through the suppression of activated microglia.

show abstract

“…We observed that the ingestion of thymol, the second major Skin blood flow, which plays an important role in the maintenance of body temperature, is innervated mainly by the sympathetic nervous system in skin blood vessels (Berne and Levy, 2000;Shen et al, 2009). Skin blood flow is controlled by two types of sympathetic nervous systems in skin blood vessels: the sympathetic noradrenergic vasoconstrictor nerves and sympathetic active vasodilator nerves (Iriki, 1989 andKellogg, 2006;Hodges and Johnson, 2009).…”

Section: Discussionmentioning

confidence: 99%

Contribution of Volatile Components in Winter Savory (<i>Satureja montana</i> L.) to Changes in Body Temperature in Humans Who Experience Cold Sensitivity

Masuda¹,

Mori

Matsui

et al. 2016

FSTR

View full text Add to dashboard Cite

We have reported that ingestion of the volatile fraction of winter savory (WSV) increased core body temperature (CBT), inhibited the decrease in body surface temperatures (BSTs) of the wrist, finger and ankle, and increased BSTs of the forehead and neck in humans who experience cold sensitivity. We also showed that carvacrol, a main component of WSV, contributed to the CBT-increase, but not to the inhibition of BSTs-decreases. Therefore, to elucidate the components in WSV affecting BST, we studied the effects of thymol, the second major component of WSV, on body temperature. Thymol ingestion inhibited BSTs-decreases of the wrist and finger. Moreover, changes in BST and CBT by a mixture of thymol and carvacrol were similar to those by WSV. These results suggest that thymol might facilitate heat transfer from the body's core to the surface, and that the combination of thymol and carvacrol greatly contributed to BST-and CBT-changes by WSV.

show abstract

Effect of 4G-α-glucopyranosyl hesperidin on brown fat adipose tissue- and cutaneous-sympathetic nerve activity and peripheral body temperature

Cited by 23 publications

References 26 publications

Effects of α-Glucosylhesperidin on the Peripheral Body Temperature and Autonomic Nervous System

Effects of α-Glucosylhesperidin on the Peripheral Body Temperature and Autonomic Nervous System

Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury

Contribution of Volatile Components in Winter Savory (<i>Satureja montana</i> L.) to Changes in Body Temperature in Humans Who Experience Cold Sensitivity

Contact Info

Product

Resources

About