Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers

Bora, Reeta; Akhtar, Shazieya; Venkatasubramaniam, Arcot; Wolfson, Julian; Rao, Raghavendra

doi:10.1038/jp.2015.92

Cited by 37 publications

(35 citation statements)

References 19 publications

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“…7 However the methods of cord milking varied across studies, while Hosono et al and Katheria et al milked 2-3times at a speed of 20cm/ 2sec. [15][16][17][18][19] All the studies have milked the cord before clamping except Upadhay et al, Kumar et al, Prateek et al that milked the cord 3 times after clamping. 7,20,21 Authors chose the technique used by Kumar et al where the cord is clamped at a distance of 25 cm and only that segment of the cord is milked three times.…”

Section: Discussionmentioning

confidence: 99%

A randomised control trial comparing the efficacy of cord milking over the delayed cord clamping on serum ferritin level in preterm neonates at 6 weeks of age

Devadas

Roshni

Mallesh

2020

Int J Contemp Pediatr

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Background: Perinatal iron deficiency has received little attention in the past. Umbilical cord milking is a type of placental transfusion, they serve to potentially enhance neonatal blood volume and consequently the iron stores after birth. Among the neonates, the preterm infants are sick and vulnerable babies who are already deprived of iron stores. The aim of this study was to evaluate the effect of cord milking on ferritin values amongst preterm neonates.Methods: This is a hospital based randomized control trial which included the babies born at 29-36 weeks of gestation. The babies were randomized to two intervention groups; cord milking and delayed cord clamping group. Detailed clinical history taken, including details of labour and clinical examination. Blood samples were analysed for ferritin as required at 6 weeks of post-natal age.Results: Neonates under cord milking group had higher ferritin values (249.04±21.93 ng/mL) as compared to those neonates under delayed cord clamping group (179.66±32.94 ng/mL) and this was statistically very significant (p= <0.001).Conclusions: In preterm neonates, umbilical cord milking results in improved iron status as shown by higher ferritin values at 6 weeks of life. UCM can be a used as placental transfusion strategy in preterm neonates for improving iron status and preventing anemia of prematurity.

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Section: Discussionmentioning

confidence: 99%

A randomised control trial comparing the efficacy of cord milking over the delayed cord clamping on serum ferritin level in preterm neonates at 6 weeks of age

Devadas

Roshni

Mallesh

2020

Int J Contemp Pediatr

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“…Nuestros resultados corroboran la utilidad del ordeño del cordón en la prevención de anemia, reducción del requerimiento de transfusiones sanguíneas, de la cantidad de transfusiones y del volumen de sangre transfundida, lo que a su vez puede ser benéfico para los recién nacidos al incrementar los depósitos de hierro desde el nacimiento hasta los 6 meses de edad, como lo describen Bora R y sus colaboradores. 26 La transfusión de glóbulos rojos, que es el procedimiento más utilizado para tratar la anemia, puede ocasionar una serie de complicaciones en el recién nacido: trasmisión de infecciones, alteraciones en la inmunomodulación, enfermedad de injerto contra huésped, lesión pulmonar aguda, aloinmunización, disturbios electrolíticos, incompatibilidad sanguínea y mayor riesgo de enterocolitis necrosante. 27 Por todo esto la transfusión de glóbulos rojos es un tratamiento temporal e imperfecto, lo que recalca la importancia de implementar procedimientos, como el ordeño del cordón umbilical, que reduzcan la necesidad de transfusiones sanguíneas.…”

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Eficacia del ordeño del cordón umbilical comparado con el pinzamiento temprano para prevenir la anemia en recién nacidos prematuros

et al. 2019

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OBJETIVO: Evaluar la eficacia del ordeño del cordón umbilical comparado con el pinzamiento temprano para prevenir la anemia en niños prematuros.MATERIALES Y MÉTODOS: Ensayo clínico abierto, con asignación al azar a uno de dos grupos: pinzamiento temprano y ordeño de cordón umbilical. Parámetros de estudio: evaluación de la hemoglobina basal, requerimiento y cantidad de transfusiones, volumen sanguíneo total transfundido y frecuencia de reacciones adversas. Para la comparación de variables continuas se utilizó t de Student, U de Mann Whitney para variables no paramétricas y c2 para variables categóricas, además del análisis multivariado corregido para trasfusión ajustada al peso al nacer, comorbilidades, hemoglobina basal y tipo de procedimiento. Se consideró significativa la p < 0.05.RESULTADOS: Se estudiaron 91 pacientes, 46 (50.5%) en el grupo con ordeño y 45 (49.5%) en el grupo con pinzamiento temprano. La hemoglobina a las 24 horas de vida en el grupo con ordeño fue significativamente mayor: 17.08 ± 2 g/dL vs 14.74 ± 1,78 g/dL; p = 0.001. La frecuencia de anemia: 22 (47.8%) vs 33 (73.3%); p = 0.001, el requerimiento de transfusión:19 (41.3%) vs 31 (68.8%); p = 0.002, y el volumen medio transfundido: 18.2 ± 33.6 mL vs 35.3 ± 45 L; p = 0.04 fueron significativamente menores en el grupo con ordeño al compararlo con el pinzamiento temprano. No hubo diferencias en policitemia (p = 0.57); hiperbilirrubinemia (p = 0.81) y estancia hospitalaria (p = 0.21). La concentración de hemoglobina basal, el peso menor de 1000 gramos, la edad gestacional menor de 30 semanas y el pinzamiento temprano se relacionaron directamente con la necesidad de transfusión.CONCLUSIONES: El ordeño del cordón umbilical es un procedimiento efectivo y seguro para prevenir la anemia en los recién nacidos prematuros.

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“…10,22 Whether DCC improves their neurodevelopment needs exploration. Finally, it will be important to test whether the results of the study could be replicated in low-and middle-income countries where maternal iron deficiency in pregnancy is highly prevalent 23,24 and infants born to those mothers have evidence of structural changes in vulnerable brain regions at birth. 25 ■…”

Section: Timing Of Umbilical Cord Clamping and Infant Brain Developmentmentioning

confidence: 99%

Timing of Umbilical Cord Clamping and Infant Brain Development

Rao

Bora

2018

The Journal of Pediatrics

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for these services. Lamentably, only 5% kept their return appointment. 6 Clearly, better ways to communicate results of maternal HCV status to infant caregivers are needed to result in improved screening of the infants if we are to achieve the very important goal of eliminating HCV. These strategies might include improved education about HCV and its natural history directed toward obstetricians and nursery staff, parents, and child protection workers, as well as foster/adoptive parents. ■

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Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers

Abstract: Keeping the umbilical cord long and milking may be an effective method for improving Hb and iron stores at 6 months of age in term-infants.

Cited by 37 publications

References 19 publications

A randomised control trial comparing the efficacy of cord milking over the delayed cord clamping on serum ferritin level in preterm neonates at 6 weeks of age

A randomised control trial comparing the efficacy of cord milking over the delayed cord clamping on serum ferritin level in preterm neonates at 6 weeks of age

Eficacia del ordeño del cordón umbilical comparado con el pinzamiento temprano para prevenir la anemia en recién nacidos prematuros

Timing of Umbilical Cord Clamping and Infant Brain Development

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