Effect of 4-Aminopyridine on the Electrical Activity of the Hippocampus and the Cerebellum

4-Aminopyridine Hydrochloride (Pymadin)

“…The convulsant actions of aminopyridines in experimental animals have been known for a long time (DOHRN 1924;DINGEMANSE and WIBAUT 1928;SHAW and BENTLEY 1949, 1952CHARONNAT et al 1953a, b;VON HAXTHAUSEN 1955;FASTIERand McDoWALL 1958a, b;LEMEIGNAN 1971;MARTINEZ DE MUNOZ 1980;GOGOLAK et al 1982), as has their ability to antagonise central depressants such as morphine and barbiturates (SHAW and BENTLEY 1949, 1952HOTovyand ROESCH 1958;VOHRA et al 1965;RAo et al 1977;TUNG and BRANDON 1982;SIA et al 1982). Recently, they have been shown to be highly effective in antagonising ketamine-diazepam anaesthesia in monkeys (MARTINEZ-AGUIRRE and CRUL 1979) and, as described later, in humans (AGOSTON et al 1980), although they have little effect against phencyclidine (S. AGOSTON 1980, unpublished work).…”