Effect of 3D microstructure of dermal papillae on SED concentration at a mechanoreceptor location

Pham, Trung Quang; Hoshi, Takayuki; Tanaka, Yoshihiro; Sano, Akihito

doi:10.1371/journal.pone.0189293

Cited by 20 publications

(16 citation statements)

References 29 publications

(51 reference statements)

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“…Although some very simple numerical models of tissue specimens have already been developed, they cannot study the whole process of human sensory-motor control. 15,38,39,47 This FE hand model has the potential to provide real-time neural spike information during active touch and other manipulation processes. The mechanical parameter which is related to human tactile perception such as strain energy density at the locations of mechanoreceptors can be derived to predict the neural signal.…”

Section: Discussionmentioning

confidence: 99%

“…22,43,47 These mechanoreceptors receive and encode the mechanical information such as strain or strain energy density (SED) and send the encoded information to somatosensory cortex. 14,38 However, these mechanical parameters such as the SED are not measurable and observable with current technology. There is no practical method to investigate the neurophysiological aspects of hand perception during manipulation.…”

Section: Introductionmentioning

confidence: 99%

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Subject-Specific Finite Element Modelling of the Human Hand Complex: Muscle-Driven Simulations and Experimental Validation

et al. 2019

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This paper aims to develop and validate a subjectspecific framework for modelling the human hand. This was achieved by combining medical image-based finite element modelling, individualized muscle force and kinematic measurements. Firstly, a subject-specific human hand finite element (FE) model was developed. The geometries of the phalanges, carpal bones, wrist bones, ligaments, tendons, subcutaneous tissue and skin were all included. The material properties were derived from in-vivo and in-vitro experiment results available in the literature. The boundary and loading conditions were defined based on the kinematic data and muscle forces of a specific subject captured from the in-vivo grasping tests. The predicted contact pressure and contact area were in good agreement with the in-vivo test results of the same subject, with the relative errors for the contact pressures all being below 20%. Finally, sensitivity analysis was performed to investigate the effects of important modelling parameters on the predictions. The results showed that contact pressure and area were sensitive to the material properties and muscle forces. This FE human hand model can be used to make a detailed and quantitative evaluation into biomechanical and neurophysiological aspects of human hand contact during daily perception and manipulation. The findings can be applied to the design of the bionic hands or neuro-prosthetics in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subject-Specific Finite Element Modelling of the Human Hand Complex: Muscle-Driven Simulations and Experimental Validation

et al. 2019

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“…Firstly, the 3D structure of skin allows us to predict the mechanical response of a population of RA-I receptors at precise positions [12]. Secondly, our model used two additional sub-layers to convert the SED into afferent current.…”

Section: Discussionmentioning

confidence: 99%

“…1). The model was developed previously in [12]. Two microstructures, fingerprint and dermal papillae (the middle region between epidermis and dermis) were included.…”

Section: Fe-model Of Skin Mechanicsmentioning

confidence: 99%

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An FE Simulation Study on Population Response of RA-I Mechanoreceptor to Different Widths of Square Indenter

Pham

Hoshi

Tanaka

et al. 2017

SICE Journal of Control, Measurement, and System Integration

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: Rapid adapting type-I (RA-I) receptor is one type of mechanoreceptors in the human skin. They are believed to be responsible for the detection of stimuli that produce minute skin motion (flutter, slip, microgeometric surface features). The neurophysiological experiments in the paper [J.R. Phillips et al. J. Neurophysiol., Vol. 46, pp. 1192-1203] raise a question about why the RA-I afferent (innervated into RA-I receptor) fails to represents the stimulus with the width less than 3 mm and why their response is anisotropy. It is unclear whether the skin's mechanics or the specific afferent branching of mechanoreceptors themselves are accounted for these phenomena. The present work seeks an interpretation of the neurophysiological phenomena, using a biomechanical finite-element (FE) model with a transduction sub-layer and synthetic sub-model for afferent current. The predicted afferent current matched well with the neural recordings in previous reports. This result suggests a major role of afferent branching in regard to the neurophysiological phenomena.

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All‐Printed Electronic Skin Based on Deformable and Ionic Mechanotransducer Array

Kim

Choi

Hwang

et al. 2020

Macromolecular Bioscience

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Mechanoreceptors in human skin possess high sensitivity, wide sensing range, and high sensing resolution for external stimuli. Several attempts have been made to implement electronic skin (e‐skin) that can mimic human skin. However, previous attempts are limited by the fundamental resolution problem arising from the use of film‐like materials generated through pouring and spinning processes. Here, an all‐printed e‐skin based on deformable ionic mechanotransducer array (IMA) inspired by the physiological tactile sensing mechanism and the geometric features of mechanoreceptors in human skin is described. First, an ionic mechanotransduction channel is emulated with a piezocapacitive ionic mechanosensory system that engages in ion migration when the polymer matrix is deformed under a mechanical non‐equilibrium state. Furthermore, the versatile shapes of the artificial mechanotransducer are tuned by the printing process variables, which results in high sensitivity (2.65 nF kPa−1) and high resolution (13.22 cm−2) of the device. It is demonstrated that this IMA is fully bio‐inspired by the mechanotransduction and papillary structure of the mechanoreceptors. A high‐resolution e‐skin with a deformable and transparent IMA, which is fabricated by an all‐printing methodology, will open up a new market in the field of soft and stretchable sensory platforms.

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Effect of 3D microstructure of dermal papillae on SED concentration at a mechanoreceptor location

Cited by 20 publications

References 29 publications

Subject-Specific Finite Element Modelling of the Human Hand Complex: Muscle-Driven Simulations and Experimental Validation

Subject-Specific Finite Element Modelling of the Human Hand Complex: Muscle-Driven Simulations and Experimental Validation

An FE Simulation Study on Population Response of RA-I Mechanoreceptor to Different Widths of Square Indenter

All‐Printed Electronic Skin Based on Deformable and Ionic Mechanotransducer Array

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