Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris

Abstract

Introduction: Thirty-percent supramolecular salicylic acid (SSA), a modified salicylic acid preparation, is a safe and effective treatment for moderate-to-severe acne vulgaris (AV). However, its mechanism of action remains unclear. We aimed to analyze the role of 30% SSA peels on skin microbiota and inflammation in patients with moderate-to-severe AV. Methods: A total of 28 patients were enrolled and received 30% SSA peels biweekly for 2 months. The Global Acne Grading System (GAGS) score, skin water content, transepidermal water loss (TEWL), pH, and sebum levels were assessed. Skin microbial samples and perilesional skin biopsies were obtained at the onset and 2 weeks after treatment completion. Samples were characterized using a high-throughput sequencing approach targeting a portion of the bacterial 16S ribosomal RNA gene. Results: After treatment, patients showed a significant improvement in their GAGS score and skin barrier indicators (P \ 0.05). The GAGS score was positively associated with both the sebum concentration (R = 0.3, P = 0.027) and pH (R = 0.39, P = 0.003). Increased expression of caveolin-1 and decreased expression of interleukin (IL)-1a, IL-6, IL-17, transforming growth factor beta, and toll-like receptor 2 were observed in the skin tissue after treatment. The richness and evenness of the cutaneous microbiome decreased after treatment and the Staphylococcus proportion decreased significantly (P \ 0.05), whereas the Propionibacterium proportion tended to decrease (P = 0.066). Conclusions: On the basis of analyses of the skin barrier and microbiota, we speculate that the 30% SSA peel may have a therapeutic effect in patients with moderate-to-severe AV by improving the skin microenvironment and modulating the skin microbiome, thus reducing local inflammation.

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“…Hyaluronic acid, one of the extracellular matrix components in the epidermis and dermis, is a type of glycosaminoglycan and is known to be degraded by hyaluronate lyase produced by C. acnes ( Nazipi et al, 2017 ; Li et al, 2021 ; Mayslich et al, 2021 ). Moreover, a previous anti-acne treatment study has reported improvement in skin barrier function (reduced TEWL) and simultaneously the relative abundance of Cutibacterium (formerly Propionibacterium ) tended to decrease ( Shao et al, 2023 ). These results can partially explain the impact of the skin microbiome on skin characteristic such as skin barrier function.…”

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