Effect of 2-Acetamido-5-Nitrothiazole and 2-Amino-5-Nitrothiazole on Egg Production, Fertility, Hatchability, and Weight Gains in Turkeys

Tissue Metabolism, Studies on Tissue Clearance and Metabolism of 2-Acetamido-5-nitrothiazole-C14 (Enheptin-A) in Turkeys

“…Saponification. Both boar fat containing boar odor and barrow-(castrated male pig) fat free from boar odor were saponified in the cold as suggested by Deuel (6). The cold saponification method has been described in some detail by Craig et al (5).…”

“…Enheptin-a (American Cyanamid Co.) is a widely used agent for the prevention and treatment of infectious enterohepatitis in turkeys (5). Studies on its chemotherapeutic effects, toxicity, and extra therapeutic effects have been reported (2,6). Previous studies, using a colorimetric method as the analytical procedure, on the clearance of this compound following withdrawal from treated birds indicated essentially complete removal within 48 hours (3).…”

Dimetridazole

“…Cooper and Skulski (1957) found that 0-05 and 0-025 P er cent °f this compound in the food produced an adverse effect on spermatogenesis and egg production, whereas the related 2-acetylamino-5-nitrothiazole (acinitrazole) had no adverse effect on egg production, fertility or embryonic mortality and apart from atrophy of single seminiferous tubules after 33 weeks, was almost free of toxic effects on the reproduction of both sexes. Price and Bottorff (1954) noted a significant decrease in fertility (8-2 per cent) when beeding turkeys were fed the acetyl compound at 0-025 P er cent in the diet, but did not consider this to be of serious economic importance.…”