Effect of 12-week intermittent calorie restriction on liver fat content in comparison with standard-of-care in patients with nonalcoholic fatty liver disease: a study protocol for a randomized controlled trial (FLICR)
Abstract:Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, and can result in various complications. Owing to the lack of effective pharmacological therapies, life style modifications are the cornerstone treatment for NAFLD. However, there has been no recommendation for a specific dietary therapy because no significant effects have been observed in previous studies. Intermittent calorie restriction (ICR), which consists of alternating phases of extreme energy restric… Show more
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