Effect of 12-month intervention with low-dose atorvastatin on pulse wave velocity in subjects with type 2 diabetes and dyslipidaemia

Grigoropoulou, Pinelopi; Tentolouris, Anastasios; Eleftheriadou, Ioanna; Tsilingiris, Dimitrios; Vlachopoulos, Charalambos; Sykara, Maria; Tentolouris, Nikolaοs

doi:10.1177/1479164118805320

Cited by 16 publications

(19 citation statements)

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“…Pulse wave velocity and PP are a non-invasive method to assess a central arterial stiffness that predicts independently CVD morbidity and mortality [ 21 ]. Increased PWV serves as target organ damage in subjects with hypertension and is included in risk stratification for CVD events [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Korogiannou et al [ 22 ] provide an overview of the field of arterial stiffness in renal transplantation and the prognostic significance of arterial stiffness for CV events, renal events and mortality in these individuals, as well as studies examining the changes in arterial stiffness following renal transplantation. PWV is considered as the ‘gold standard’ method for the assessment of arterial stiffness [ 21 ]. Increased aortic stiffness leads to a premature return in heart’s late systole and increases central PP and SBP.…”

Section: Discussionmentioning

confidence: 99%

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Influence of lipid profile and statin administration on arterial stiffness in renal transplant recipients

et al. 2022

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Background: Hyperlipidemia is one of the major risk factors for developing a cardiovascular disease (CVD) and it is a frequent post-transplant complication, occurring in up to 60% of the renal transplant recipients (RTRs). Lipid lowering therapy with HMG-CoA reductase inhibitors (statins) is generally recommended and may reduce the overall cardiovascular risk. The aim of this study was to evaluate the lipid profile, statin administration and their relationship with arterial stiffness parameters in renal transplant recipients. Methods: Three hundred and forty-four stable RTRs (62.5% male) transplanted between 1994 and 2018 were randomly enrolled to the study. The following parameters of arterial stiffness was measured in each patient: carotid femoral pulse wave velocity (baPWV left and right, cfPWV) and pulse pressure (PP right and left). The study group was divided based on the use statins: 143 (41.6%) and 201 (58.4%). RTRs were qualified to the statin (+) and the statin (-) group, respectively. Results: In the statin (+) as compared to statin (-) group there were more patients with a CVD (32.9% vs. 14.9%) and diabetes (25.2% vs. 14.4%). In the whole study group, CVD was associated with a significant increase of both baPWV and cfPWV as well as PP (8.5 mmHg). There were significant differences in arterial stiffness parameters (baPWV, cfPWV, PP) between the statin (+) and the statin (-) group. Conclusions: Arterial stiffness was increased in RTRs with CVD and hyperlipidemia. The control of hyperlipidemia was poor in RTRs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of lipid profile and statin administration on arterial stiffness in renal transplant recipients

et al. 2022

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“…In our study, age, sex, serum uric acid levels, smoking, antihyperlipidemic drug use, BMI, and CKD duration were not found to have significant correlations with PWV, conflicting with some studies. 20 - 24 The main limitation of our study is that it has a relatively heterogeneous population due to the age range of 28-89 and GFR in the range of 9-64 mL/min, although it excluded stage 1 and dialysis-dependent patients.…”

Section: Discussionmentioning

confidence: 99%

The association between Hba1c and arterial stiffness among non-diabetic patients with chronic kidney disease

Turgutkaya

Aşçı

2021

J. vasc. bras.

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Background Cardiovascular events are seen more frequently after the age of 60 and they are a significant cause of morbidity and mortality. Arterial stiffness is a property that can be expressed by pulse wave velocity and this value is assumed to be a predictor of cardiovascular events. Patients with chronic kidney disease and dysregulated blood sugar have increased atherosclerosis and arterial stiffness, but the relationship between physiological levels of Hba1c and arterial stiffness is less clear in chronic kidney disease patients without diabetes mellitus. Objectives Here, we aimed to investigate the degree of arterial stiffness among non-diabetic, non-dialysis dependent chronic kidney disease patients with physiological HbA1c levels. Methods We enrolled 51 patients who were followed up at Ege University Hospital Nephrology Department between February and June 2015. Non-diabetic, non-dialysis dependent chronic kidney disease patients were included in the study. Blood pressure and pulse wave velocity were measured with an applanation tonometry device (Sphygmocor Vx Software Atcor Medical, Australia). Correlations between pulse wave velocity and the aforementioned parameters were investigated (see below). Results We detected a significant correlation between pulse wave velocity and systolic blood pressure (p=0.0001) and Hba1c (p=0.044) separately. There was an inverse correlation with creatinine clearance (p=0.04). We also detected a significant correlation with serum phosphorus level (p=0.0077) and furosemide use (p=0.014). No correlations were found among the other parameters. Conclusions Arterial stiffness is an important predictor of cardiovascular events and measuring it is an inexpensive method for estimating morbidity and mortality. Our study supports the importance of measuring arterial stiffness and of controlling blood glucose levels, even at physiological Hba1c values, especially for chronic kidney disease patients.

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“…In a recent prospective study of participants with type two diabetes mellitus with dyslipidemia being treated with diet and low-dose atorvastatin, a 7.5% reduction in carotid-femoral PWV was observed at 12 weeks from baseline with statistical significance (P<0.001). [46] The previously mentioned Fiedorowicz et al study on endothelial dysfunction during medical internship investigated changes in reactive hyperemia index at baseline and one year later, another indication that changes in vascular function need to be studied over a longer period of time. [8] The sample was not aggressively treated with only two participants achieving remission (MADRS<10) and followed for only eight weeks.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and Vascular Correlates of Mood Change Over 8 Weeks

et al. 2019

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Background-Mood disorders have been associated with a variety of cardiovascular disease risk factors, including inflammation and large artery stiffness, particularly while depressed although longitudinal studies have been limited. Methods-With measurements at baseline and 8 weeks, the researchers prospectively assessed mood, levels of inflammatory markers (hsCRP and TNF-α), serum lipids, and large artery stiffness in a cohort of 26 participants with a diagnosis of a mood disorder, enriched for current depression. Depressive symptoms were measured using the Montgomery-Åsberg Depression Rating Scale (MADRS) at baseline and 8 weeks. Associations between depressive symptoms and other measures were assessed using linear mixed models, unadjusted and adjusted for age and BMI. Results-The mean age of the participants (n=26) was 41.6 (standard deviation [SD] 12.8) years, and 81% were female. During the study, there was a mean (SD) MADRS score improvement of 9.5 (9.4) from baseline to eight weeks. Reductions in the primary outcome TNF-α with improvement in depression fell short of significance (P=0.076). In secondary analyses, there was a statistically significant association between improved cholesterol ratio (P=0.038) and triglycerides (P=0.042) with depression improvement. There was no statistically significant change in large artery stiffness during the study. Conclusion-Improved depressive symptoms were associated with improved cholesterol ratios even after adjustment, suggesting possible mechanism by which acute mood states may influence cardiovascular disease risk. Future longitudinal studies with extended and intensive follow-up investigating cardiovascular disease risk related to acute changes and persistence of mood symptoms is warranted.

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Effect of 12-month intervention with low-dose atorvastatin on pulse wave velocity in subjects with type 2 diabetes and dyslipidaemia

Cited by 16 publications

References 54 publications

Influence of lipid profile and statin administration on arterial stiffness in renal transplant recipients

Influence of lipid profile and statin administration on arterial stiffness in renal transplant recipients

The association between Hba1c and arterial stiffness among non-diabetic patients with chronic kidney disease

Inflammatory and Vascular Correlates of Mood Change Over 8 Weeks

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