Effect of 1(4-Amino-2-methyl-5-pyrimidinyI), methyl-3-(2-chloroethyl)-3-nitrosourea Hydrochloride (ACNU) on Sato Lung Carcinoma (SLC)

Abstract

ACNU was highly effective for Sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of ACNU for SLC showed clear dependence upon tumor size. Nonspecific activation of host-defence mechanism by Propionibacteriumacnes contributed to the suppression for the regrowth of solid SLC treated by ACNU.

Highlights for ESMO 40: celebration review for lifetime achievement awards

“…When I graduated from University, SCLC was primarily treated with mitomycin C alone in the National Cancer Center (Japan). In the late 1970s, ACNU (a water-soluble nitrosourea compound), developed by Sankyo Co (Japan), showed surprising antitumour effects in SCLC preclinically, 31 and clinically it was very active in extensive disease (ED)-SCLC. 32 The survival time of ED-SCLC treated with ACNU has reached the state of the art in the 1970s.…”

Effects of BCG and 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) on the cytostatic activity of macrophages in normal and tumour-bearing rats

“…administration of BCG (Chikama et al, 1979). AVe have also investigated the effect of immunopotentiators in the clinically relevant model of immunochemotherapy for advanced solid tumours (Saijo et al, 1979b).…”

“…Male Donryni strain rats weighing 120- (Saijo et al, 1978(Saijo et al, , 1979 immunized rats rejecting > 107 viable tumour cells, whilst the minimum inoculum for growth in uinimmunized rats is 104 cells. In the experiments described here, tumours used as the source of target cells for cytostatic assay were taken 7 days after s.c. injection of 107 shown by (Giemsa stain, and by their phagocytic activity for Indian-ink particles.…”