Effect of 1,25-dihydroxy-vitamin D<sub>3</sub> in experimental sepsis

Möller, Sören; Laigaard, Finn; Ølgaard, Klaus; Hemmingsen, Claus

doi:10.7150/ijms.4.190

Cited by 62 publications

(49 citation statements)

References 20 publications

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“…28,29 In the current study, blood biochemistry showed no significant effect on hepatic function with LPS even though minor histological lesions were present in all LPS groups, suggesting that sufficient normal hepatic tissue is still present to preserve liver function. Even without lesions, hypoalbuminemia and hypoproteinemia are frequently observed with isoflurane or ketamine-xylazine anesthesia, 10,30 suggesting an effect on hepatic metabolism.…”

Section: Discussioncontrasting

confidence: 46%

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague–Dawley rats

Veilleux-Lemieux¹,

Beaudry²,

Hélie³

et al. 2012

VMRR

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Purpose:To evaluate the effects of endotoxemia on the pharmacokinetics and pharmacodynamics of ketamine and xylazine anesthesia in Sprague-Dawley rats. Methods: Sprague-Dawley rats received ketamine (80 mg/kg) and xylazine (5 mg/kg) intramuscularly following the intraperitoneal administration of different lipopolysaccharide concentrations (1, 10, and 100 µg/kg) to simulate different levels of endotoxemia. Results were compared to control animals receiving saline intraperitoneally. During anesthesia, a toe pinch was performed to evaluate anesthesia duration, and selected physiological parameters (heart and respiratory rates, oxygen saturation, and rectal temperature) were taken. Blood samples were also taken during anesthesia at selected time points for the analysis of plasmatic ketamine and xylazine concentrations by liquid chromatography-mass spectrometry. Blood samples were taken 1 week prior to and 24 hours following anesthesia for blood biochemistry. Results: Anesthesia duration significantly increased for moderate (10 µg/kg) and high (100 µg/kg) lipopolysaccharide groups. Liver histopathology showed minor to moderate necrosis in all lipopolysaccharide groups in some animals. The most important physiological change that occurred was a decrease in oxygen saturation, and for blood biochemistry a decrease in serum albumin. Ketamine pharmacokinetics were not affected except for the moderate (10 µg/kg) lipopolysaccharide group where a decrease in the area under the plasma concentration-time curve from time zero to the last measurable concentration, a decrease in half-life, and an increase in the clearance were observed. For xylazine, the area under the plasma concentration-time curve increased and the clearance decreased in the moderate (10 µg/kg) and high (100 µg/kg) lipopolysaccharide groups. Conclusion: During ketamine-xylazine anesthesia, endotoxemia may alter xylazine pharmacokinetics and selected biochemical and physiological parameters, suggesting that anesthetic drug dosages could be modified for a more rapid recovery.

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Section: Discussioncontrasting

confidence: 46%

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague–Dawley rats

Veilleux-Lemieux¹,

Beaudry²,

Hélie³

et al. 2012

VMRR

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“…The severity of an infection is negatively correlated to serum vitamin D concentrations. These findings proposed another important role for this vitamin in the progression of sepsis pathogenesis (11)(12)(13). The…”

Section: Introductionmentioning

confidence: 74%

RETRACTED ARTICLE: Evaluation of the Relationship Between Serum Vitamin D Level and Severity of Sepsis

Ahmadi

Doluee

Pouryaghobi

et al. 2016

Iran Red Crescent Med J

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Background: On the basis of the literature, vitamin D is known as an important medium in bodily immune function, and it therefore may play a role in the pathogenesis of sepsis. Objectives: In this study, we aimed to evaluate the relationship between vitamin D serum levels and sepsis severity. Patients and Methods:This study was a case-control study that evaluated adult patients admitted to the emergency department of Imam Reza hospital with suspected sepsis. These patients were enrolled in the study as the case group. In addition, healthy individuals without the sepsis diagnostic criteria were included in the control group. For all of the study participants, vitamin D levels were evaluated. The acute physiology age chronic health evaluation (APACHE) was used to evaluate disease severity in the case group. A difference of P < 0.05 was regarded as statistically significant. Results: A total of 112 patients were assessed: 56 in the control group and 56 in the case group. In the case group, 18 patients had sepsis, 25 patients had severe sepsis, and 13 patients were in septic shock. The mean ages of the patients in the case and control groups were 57.7 ± 15.15 and 58.6 ± 15.05 years, respectively (P = 0.741). Vitamin D levels in the case group were lower than in the control group (16.3 ± 10.7 versus 27.9 ± 11.46 ng/mL), and the difference between the groups was significant (P < 0.001). Mean vitamin D levels in the severe sepsis and septic shock groups were lower than in the sepsis group, and the mean level in the septic shock group was lower than in the severe sepsis group (P = 0.001). In the case group, there was a significant reverse correlation between APACHE II criteria and vitamin D levels (P < 0.001, r = -0.586). Conclusions:The results of this study indicated that patients with sepsis had lower serum vitamin D levels than healthy controls. Also, patients with more severe disease had lower serum vitamin D levels, but to evaluate causation and determine whether vitamin D supplementation could be effective in reducing the risk or severity of sepsis, randomized controlled trials should be conducted.

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“…Furthermore, vitamin D insufficiency may also be important in the pathogenesis of sepsis, the most fatal consequence of infection. In vitro and in vivo models of sepsis suggest that vitamin D treatment modulates proinflammatory cytokine production, deranged coagulation and activation of the vascular endothelium, as seen in sepsis syndromes [6,9,10].…”

Section: Introductionmentioning

confidence: 99%

Is there an association between periprosthetic joint infection and low vitamin D levels?

Maier

Horas

Seeger

et al. 2014

International Orthopaedics (SICOT)

102

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Purpose Vitamin D is increasingly being recognized as an important mediator of immune function and may have a preventive role in the pathogenesis of periprosthetic joint infection. To the best of our knowledge, no other study has examined possible associations between periprosthetic joint infection and vitamin D deficiency. We investigated the rate of vitamin D deficiency in patients treated for periprosthetic joint infection and whether vitamin D deficiency is independent of other risk factors for vitamin D deficiency in patients with periprosthetic joint infection. Methods Serum 25-hydroxyvitamin D (25OHD) levels of every patient scheduled to receive a total prosthesis either of the hip, knee, or shoulder in the orthopaedic department of the Johannes-Guttenberg-University Hospital in Mainz, Germany (109 patients), were measured after admission. Furthermore, serum 25OHD levels were measured for every patient presenting with periprosthetic joint infection (n=50) or aseptic loosening of the prosthesis (n=31) scheduled to undergo revision surgery. The prevalence of normal (>30 ng/ml), insufficient (20-30 ng/ml), and deficient (<20 ng/ml) 25OHD levels was determined. Results All tested patient subgroups showed low vitamin D levels. Statistical analysis found no significant difference in vitamin D levels comparing patients with prosthesis and patients with aseptic prosthesis loosening (p=0.58). Significant differences in 25OHD levels were found comparing patients with periprosthetic joint infection and patients scheduled for primary arthroplasty (p<0.001). In addition, we found a significant difference (p<0,001) in 25OHD levels of patients with periprosthetic joint infection compared with patients with aseptic prosthesis loosening. Conclusion We found a high frequency of vitamin D deficiency in patients being treated by primary arthroplasty and those with aseptic joint prosthetic loosening and periprosthetic joint infection. Vitamin D deficiency was severe in patients with periprosthetic joint infection.

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Effect of 1,25-dihydroxy-vitamin D₃ in experimental sepsis

Cited by 62 publications

References 20 publications

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague–Dawley rats

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague–Dawley rats

RETRACTED ARTICLE: Evaluation of the Relationship Between Serum Vitamin D Level and Severity of Sepsis

Is there an association between periprosthetic joint infection and low vitamin D levels?

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Effect of 1,25-dihydroxy-vitamin D3 in experimental sepsis

Cited by 62 publications

References 20 publications

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague&ndash;Dawley rats

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague&ndash;Dawley rats

RETRACTED ARTICLE: Evaluation of the Relationship Between Serum Vitamin D Level and Severity of Sepsis

Is there an association between periprosthetic joint infection and low vitamin D levels?

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Effect of 1,25-dihydroxy-vitamin D₃ in experimental sepsis

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague–Dawley rats

Effects of endotoxemia on the pharmacodynamics and pharmacokinetics of ketamine and xylazine anesthesia in Sprague–Dawley rats