Effect modification in network meta-analyses for relapsed/refractory multiple myeloma: systematic review and meta-analysis
Christopher James Rose,
Ingrid Kristine Ohm,
Liv Giske
et al.
Abstract:ObjectivesTo systematically review and meta-analyse the evidence for effect modification by refractory status and number of treatment lines in relapsed/refractory multiple myeloma (RRMM); and to assess whether effect modification is likely to invalidate network meta-analyses (NMA) that assume negligible modification.DesignSystematic review, meta-analysis and simulation.Data sourcesWe systematically searched the literature (e.g., OVID Medline) to identify eligible publications in February 2020 and regularly upd… Show more
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