Effect modification by apoptosis-related gene polymorphisms on the associations of phthalate exposure with spermatozoa apoptosis and semen quality

Pan, Yang; Gong, Yajie; Wang, Yi‐Xin; Liang, Xin-Xiu; Liu, Qing; Liu, Chong; Chen, Yingjun; Sun, Li; Lu, Wen-Qing; Zeng, Qiang

doi:10.1016/j.envpol.2017.08.034

Cited by 12 publications

(2 citation statements)

References 39 publications

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“…Moreover, exposure to this toxic agent also induced spontaneous sperm acrosome reaction, reduced the physiological response to progesterone, and increased caspase activity, all of which suggest triggering of an apoptotic pathway [ 91 ]. It was also found that apoptosis-related gene polymorphisms might contribute to the effects of phthalate exposure on male reproductive health [ 92 ].…”

Section: Resultsmentioning

confidence: 99%

From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality

2022

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Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction and development. In male reproductive health, EDCs have been related to impaired reproductive function and male infertility, altered fetal development, and testicular germ-cell, prostate, and breast cancers. We conducted an electronic search using PubMed on endocrine disruptors related to oxidative stress and male infertility, and evaluated their association with endocrine-disrupting chemicals (bisphenols, phthalates, and parabens) in 25 articles. Higher levels of urinary bisphenols showed correlation with impaired semen quality and increased DNA damage. Considering phthalates and their metabolites, all studies found a positive association between urinary levels of phthalates and at least one semen parameter indicative of low semen quality; some studies also revealed sperm DNA damage. The studies on parabens less often revealed correlation of urinary parabens concentrations with a decrease in sperm count, as well as motility and DNA damage. Moreover, EDCs can elevate ROS production and lipid peroxidation, increase apoptosis, induce epigenetic modifications, and change the Y:X sperm chromosome ratio and sperm protein composition. Our review revealed detrimental effects of EDCs on semen quality and sperm DNA integrity—especially in BPA and phthalates, but also in parabens.

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Section: Resultsmentioning

confidence: 99%

From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality

2022

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“…Genetic diversity may also contribute to the variation in response to chemical exposure. Genetic analysis of Chinese men undergoing semen assessment at an infertility clinic provided evidence that polymorphic variation in apoptosis‐related genes may contribute to the effects of phthalate exposure on male semen quality 24 . Therefore, these combined studies underscore the importance of considering subject variability when assessing the effects of phthalates on reproductive health.…”

Section: Subject Variability In Response To Phthalate Exposurementioning

confidence: 99%

Exposure to phthalates: germline dysfunction and aneuploidy

Henderson

Colaiácovo

2021

Prenatal Diagnosis

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Epidemiological studies continue to reveal the enduring impact of exposures to environmental chemicals on human physiology, including our reproductive health. Phthalates, a well characterized class of endocrine disrupting chemicals and commonly utilized plasticizers, are among one of the many toxicants ubiquitously present in our environment. Phthalate exposure has been linked to increases in the rate of human aneuploidy, a phenomenon that is detected in 0.3% of livebirths resulting in genetic disorders including trisomy 21, approximately 4% of stillbirths, and over 35% of miscarriages. Here we review recent epidemiological and experimental studies that have examined the role that phthalates play in germline dysfunction, including increases in apoptosis, oxidative stress, DNA damage, and impaired genomic integrity, resulting in aneuploidy. We will further discuss subject variability, as it relates to diet and polymorphisms, and the sexual dimorphic effects of phthalate exposure, as it relates to sex‐specific targets. Lastly, we discuss some of the conserved effects of phthalate exposure across humans, mammalian models and nonmammalian model organisms, highlighting the importance of using model organisms to our advantage for chemical risk assessment and unveiling potential mechanisms that underlie phthalate‐induced reproductive health issues across species.

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