Effect Methanolic Extract of <i>Achyranthus aspera</i> on Biochemical Status of Albino Mice

Abstract

The effect of administration of Methanolic extract of Achyranthsu asper on biochemical parameter of mice were investigated. This drug induced significant reduction in the cholesterol level and amount of RNA. But significant increase in the amount of glycogen at 25 mg/kg and no significant reduction in the amount of glycogen at 50 mg/kg. This drug also induced increase in the level of alkaline phospatese and decrease in the level of acid phosphatase, protein and DNA, but these changes are statistically not significant. Protein 25 mg shows 4.22 ±0.112 and 50 mg shows 4.05 ±0.085. Cholesterol 25mg shows 0.5 ±0.04 and 50 mg shows 0.39 ±0.038. Glycogen 25mg shows 0.288 ±0.011 and 50mg shows 0.248 ±0.177. DNA 25mg shows 0.109 ±0.039 and 50 mg shows 0.085 ±0.035, RNA 25mg shows 0.38 ±0.036 and 50 mg shows 0.25 ±0.031

A Comprehensive Study on Ethno-Pharmacological Exploration of Achyranthes aspera Linn.

“…On the other hand, administration of Achyranthes aspera leaves methanolic extract at the dosage 25 and 50 mg/kg body weight were reported to have anti-ovulatory and estrogenic activities, but failed to show any teratogenic, antiimplantation and abortifacient activity. At these dose levels, the Achyranthes aspera leaves showed safety in efficacy and might be used as an herbal contraceptives in females (Reddy et al, 2016). Teratogenic toxicity of oral administration with ethanolic extract of leaves of Achyranthes aspera (250, 500 and 1000 mg/kg) from day 6-12 of gestation was evident in terms of reduction in number of implantation sites, retardation in development of embryo and foetus, elevation in rate of foetal resorption and death as well as significant reduction in litter weight and Crown-Rump Length (CRL) (Teshome et al, 2021).…”