Effect‐Based Trigger Values Are Essential for the Uptake of Effect‐Based Methods in Water Safety Planning

Neale, Peta A.; Escher, Beate I.; Baat, Milo L. de; Enault, Jérôme; Leusch, Frederic

doi:10.1002/etc.5544

Cited by 18 publications

(10 citation statements)

References 84 publications

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“…Suspect screening presents a way to expand the contaminant list (from hundreds to thousands) during instrumental analysis and potentially improve explanatory capabilities for observed effects in the environment. , While suspect screening is attracting more attention, it is still limited by subjective preselection of analytes, although much larger contaminant lists instead of target analysis are applied. Meanwhile, an expanded list of analytes requires increased labor and cost, so most suspect screening can provide only semiquantitative results for a limited number of samples. − Thus, it is imperative to advance cost-efficient new approach methodologies (NAMs) as complementary tools to costly instrument-based technologies.…”

Section: Introductionmentioning

confidence: 99%

“…While some highly specific receptor-mediated bioactivity (e.g., estrogenic activity) may be well explained by a limited number of known and potent contaminants, for most effects (e.g., oxidative stress responses), it is extremely difficult to identify causative agents in complex mixtures. 7 Suspect screening presents a way to expand the contaminant list (from hundreds to thousands) during instrumental analysis and potentially improve explanatory capabilities for observed effects in the environment. 2,8 While suspect screening is attracting more attention, it is still limited by subjective preselection of analytes, although much larger contaminant lists instead of target analysis are applied.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Niu et al found commonly analyzed target contaminants can explain only <10% observed responses in aquatic samples. While some highly specific receptor-mediated bioactivity (e.g., estrogenic activity) may be well explained by a limited number of known and potent contaminants, for most effects (e.g., oxidative stress responses), it is extremely difficult to identify causative agents in complex mixtures …”

Section: Introductionmentioning

confidence: 99%

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Text Mining-Based Suspect Screening for Aquatic Risk Assessment in the Big Data Era: Event-Driven Taxonomy Links Chemical Exposures and Hazards

Cheng

Huang

et al. 2023

Environ. Sci. Technol. Lett.

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To improve the accuracy of mixture risk assessment, researchers are employing suspect analysis with expanded lists of contaminants in addition to conventional target lists. However, there are some inherent challenges for these instrument-based analyses, including subjective selection of suspect contaminants, no information for chemical bioactivity, requirements for costly verification, and limited regional coverage. As a supplementary approach, we propose a data-driven suspect screening and risk assessment method informed by mining big data from high-throughput screening bioassay platforms and the refereed literature. The Pearl River Delta (PRD) with main event drivers of arylhydrocarbon receptor (AhR) and oxidative stress (ARE) response was examined. Bioactivity concentrations were collected from the CompTox Chemicals Dashboard, which contained more than 900 000 substances. In addition, exposure metadata from 24 986 literature entries for the environmental occurrence and distribution of contaminants in the PRD over the past three decades were mined. Collectively, a regional distribution map of aquatic hazards induced by AhR- and ARE-active compounds was generated, indicating gradients of low to moderate risks. This study specifically reports a novel big data approach for addressing the increasingly common challenge of objectively selecting analytes during suspect screening, which was recently identified as an urgent research question to advance more sustainable environmental quality.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Text Mining-Based Suspect Screening for Aquatic Risk Assessment in the Big Data Era: Event-Driven Taxonomy Links Chemical Exposures and Hazards

Cheng

Huang

et al. 2023

Environ. Sci. Technol. Lett.

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“…In cases in which there is no significant cytotoxicity, but the effect in the assay still exceeds the corresponding EBT (e.g., oxidative stress EBT for an oxidative stress assay), applying bioassays responsive to receptor-mediated effects is recommended to determine if they are also exceeding their respective EBTs. Further information and an interpretation framework for EBT exceedance can be found in ref .…”

Section: What To Do With Information Provided By Effect-based Methodsmentioning

confidence: 99%

Application of Effect-Based Methods to Water Quality Monitoring: Answering Frequently Asked Questions by Water Quality Managers, Regulators, and Policy Makers

Neale

Escher

Baat

et al. 2023

Environ. Sci. Technol.

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Effect-based methods (EBM) have great potential for water quality monitoring as they can detect the mixture effects of all active known and unknown chemicals in a sample, which cannot be addressed by chemical analysis alone. To date, EBM have primarily been applied in a research context, with a lower level of uptake by the water sector and regulators. This is partly due to concerns regarding the reliability and interpretation of EBM. Using evidence from the peer-reviewed literature, this work aims to answer frequently asked questions about EBM. The questions were identified through consultation with the water industry and regulators and cover topics related to the basis for using EBM, practical considerations regarding reliability, sampling for EBM and quality control, and what to do with the information provided by EBM. The information provided in this work aims to give confidence to regulators and the water sector to stimulate the application of EBM for water quality monitoring.

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“…B. I. Escher et al, 2018a;Neale et al, 2023). In addition to standardizing EBT development, the recycled water monitoring protocols for the State of California also contain trigger level values for estrogenic and dioxin-like activity (Denison et al, 2020).…”

Section: Effects-based Trigger Valuesmentioning

confidence: 99%

Water, Water Everywhere, but Every Drop Unique: Challenges in the Science to Understand the Role of Contaminants of Emerging Concern in the Management of Drinking Water Supplies

Glassmeyer,

Burns,

Focazio

et al. 2023

GeoHealth

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The protection and management of water resources continues to be challenged by multiple and ongoing factors such as shifts in demographic, social, economic, and public health requirements. Physical limitations placed on access to potable supplies include natural and human‐caused factors such as aquifer depletion, aging infrastructure, saltwater intrusion, floods, and drought. These factors, although varying in magnitude, spatial extent, and timing, can exacerbate the potential for contaminants of concern (CECs) to be present in sources of drinking water, infrastructure, premise plumbing and associated tap water. This monograph examines how current and emerging scientific efforts and technologies increase our understanding of the range of CECs and drinking water issues facing current and future populations. It is not intended to be read in one sitting, but is instead a starting point for scientists wanting to learn more about the issues surrounding CECs. This text discusses the topical evolution CECs over time (Section 1), improvements in measuring chemical and microbial CECs, through both analysis of concentration and toxicity (Section 2) and modeling CEC exposure and fate (Section 3), forms of treatment effective at removing chemical and microbial CECs (Section 4), and potential for human health impacts from exposure to CECs (Section 5). The paper concludes with how changes to water quantity, both scarcity and surpluses, could affect water quality (Section 6). Taken together, these sections document the past 25 years of CEC research and the regulatory response to these contaminants, the current work to identify and monitor CECs and mitigate exposure, and the challenges facing the future.

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Effect‐Based Trigger Values Are Essential for the Uptake of Effect‐Based Methods in Water Safety Planning

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 18 publications

References 84 publications

Text Mining-Based Suspect Screening for Aquatic Risk Assessment in the Big Data Era: Event-Driven Taxonomy Links Chemical Exposures and Hazards

Text Mining-Based Suspect Screening for Aquatic Risk Assessment in the Big Data Era: Event-Driven Taxonomy Links Chemical Exposures and Hazards

Application of Effect-Based Methods to Water Quality Monitoring: Answering Frequently Asked Questions by Water Quality Managers, Regulators, and Policy Makers

Water, Water Everywhere, but Every Drop Unique: Challenges in the Science to Understand the Role of Contaminants of Emerging Concern in the Management of Drinking Water Supplies

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