Effect and timing of parathyroid hormone analog administration for preventing medication-related osteonecrosis of the jaws in a murine model

Jung, Junho; Shim, Gyu Jo; Kim, Minah; Yoon, Youngjae; Kim, Jae Eun; Jue, Seong Suk; Al‐Nawas, Bilal; Kwon, Yong‐Dae

doi:10.1016/j.jcms.2021.02.023

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…Thus, the MRONJ-like lesions should exist for at least one week in rodents before verifying the successful establishment of the MRONJ model. The total duration ranges from 2 weeks 68 to 17 weeks 56 , 58 , although it exceeds eight weeks in most studies 31 , 44 , 45 , 69 – 72 , indicating a relatively long induction period.…”

Section: Approaches Of Establishing Mronj Modelsmentioning

confidence: 99%

“…The definition of necrotic bone depends on the number of confluent empty or karyolytic osteocytic lacunae. Empty bone lacunae 30 , 45 , 95 , 96 , 98 The proportion or the number of empty bone lacunae in a certain area indicates the degree of osteocyte loss, which present the bone necrosis. TRAP + osteoclast 44 , 49 , 57 , 58 , 64 , 67 , 69 , 72 , 93 , 95 – 101 The TRAP + osteoclasts present the bone resorption, commonly used indicators including numbers of osteoclast per area or per bone line.…”

Section: Assessment Of Mronj-like Lesions In Rodent Modelsmentioning

confidence: 99%

“…Mucosal healing and bone exposure are two important indexes in gross observation. Most studies mainly describe the gross MRONJ as “incomplete and delayed mucosal healing and bone exposure” 30 , 44 , 45 , 47 , 62 , 64 , 67 , 72 , 93 – 96 . However, in infection-induced MRONJ rodent models, the gross observation may only present mild to moderate inflammation with soft tissue swelling and erythema without exposure to bone tissue on probing 45 , 85 .…”

Section: Assessment Of Mronj-like Lesions In Rodent Modelsmentioning

confidence: 99%

“…Most studies mainly describe the gross MRONJ as “incomplete and delayed mucosal healing and bone exposure” 30 , 44 , 45 , 47 , 62 , 64 , 67 , 72 , 93 – 96 . However, in infection-induced MRONJ rodent models, the gross observation may only present mild to moderate inflammation with soft tissue swelling and erythema without exposure to bone tissue on probing 45 , 85 . For pulp-exposed MRONJ rodent models, there may even be no oral mucosal lesion or exposed bone observed 39 .…”

Section: Assessment Of Mronj-like Lesions In Rodent Modelsmentioning

confidence: 99%

“…The area of necrotic bone was defined as the bone area with empty osteocyte lacunae, and the necrotic bone ratio was defined as the ratio of empty occupied osteocyte lacunae 59 , 60 . Instead of measuring necrotic bone, some studies directly used the average number of empty lacunae per area to indicate bone necrosis 30 , 45 , 95 , 96 , 98 . According to the histology images and statistics presented in different studies, it should be more objective and persuasive to calculate the empty lacunae and analyze the necrotic bone area to reflect the overall situation of bone defects.…”

Section: Assessment Of Mronj-like Lesions In Rodent Modelsmentioning

confidence: 99%

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Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

Yan

Jiang

et al. 2022

Int J Oral Sci

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Medication-related osteonecrosis of the jaw (MRONJ) is primarily associated with administering antiresorptive or antiangiogenic drugs. Despite significant research on MRONJ, its pathogenesis and effective treatments are still not fully understood. Animal models can be used to simulate the pathophysiological features of MRONJ, serving as standardized in vivo experimental platforms to explore the pathogenesis and therapies of MRONJ. Rodent models exhibit excellent effectiveness and high reproducibility in mimicking human MRONJ, but classical methods cannot achieve a complete replica of the pathogenesis of MRONJ. Modified rodent models have been reported with improvements for better mimicking of MRONJ onset in clinic. This review summarizes representative classical and modified rodent models of MRONJ created through various combinations of systemic drug induction and local stimulation and discusses their effectiveness and efficiency. Currently, there is a lack of a unified assessment system for MRONJ models, which hinders a standard definition of MRONJ-like lesions in rodents. Therefore, this review comprehensively summarizes assessment systems based on published peer-review articles, including new approaches in gross observation, histological assessments, radiographic assessments, and serological assessments. This review can serve as a reference for model establishment and evaluation in future preclinical studies on MRONJ.

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