Effect and safety of combined Gegen Qinlian decoction/metformin in the treatment of diabetes mellitus in patients, and its influence on serum C peptide and glycosylated hemoglobin

Chen, Jie; Xu, Yangsheng; Yan, Zhao; Liu, Geling; Chen, Jia; Li, Yan; Li, Weijuan

doi:10.4314/tjpr.v21i5.20

Cited by 2 publications

(1 citation statement)

References 17 publications

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“… 24 Since GQD is a combination of several Chinese herbs, the effects of GQD are multi-factorial with complex mechanistic effects in T2DM, but Tu et al found that the anti-diabetic/or antihyperglycemic effects of GQD worked by regulating adipocytic PPARα and PPARγ signaling systems to maintain glucose and lipid metabolisms. 23 In this study, it was found that the combination of GQD and metformin can significantly reduce FBG, 2h PG, HbA1c levels and improve TCM syndrome, which supported the findings by Chen et al 25 …”

Section: Discussionsupporting

confidence: 88%

Gegen Qinlian Decoction combined with Metformin for the treatment of patients with Type-2 Diabetes Mellitus: A retrospective observational study

Chen¹,

Zhou²,

Jiang³

et al. 2023

Pak J Med Sci

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Objectives: To investigate Gegen Qinlian Decoction (GQD) combined with metformin for treatment of patients with Type-2 Diabetes Mellitus (T2DM). Methods: This retrospective observational study reviewed the clinical data of 89 patients diagnosed with T2DM in the Department of Acupuncture and Massage, Hainan Medical University from January 2021 to June 2022. Patients were non-randomized and divided into two groups based on the treatment received: observation group (n=41, GQD combined with metformin); control group (n=48, metformin only). Fasting blood glucose levels (FBG), traditional Chinese medicine (TCM) syndrome scores, clinical effect, blood glucose time in range and adverse reactions were compared between the two groups. Results: There were no statistically significant differences in age, gender, BMI and duration of T2DM between the two groups (P>0.05). The FBG, 2h glucose, HbA1c levels and TCM syndrome scores of the two groups were significantly lower post-treatment (P<0.001) with a greater decrease in the observation group (P<0.001). The observation group was more clinically efficacious than the control group post-treatment (92.68% vs. 77.08%; P<0.05). Blood glucose time in range and the incidence of adverse reactions were lower in the observation group than the control group (P<0.001 and P<0.05). Conclusions: GQD combined with metformin can significantly reduce FBG, 2h glucose and HbA1c levels, and improve TCM syndrome, with good clinical efficacy, shorter blood glucose time in range and less adverse reactions. doi: https://doi.org/10.12669/pjms.39.4.7776 How to cite this: Chen Y, Zhou X, Jiang Z, Liu Y. Gegen Qinlian Decoction combined with Metformin for the treatment of patients with Type-2 Diabetes Mellitus: A retrospective observational study. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.7776 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 88%