Effect and Mechanism of Sodium Butyrate on Neuronal Recovery and Prognosis in Diabetic Stroke

Li, Tingting; Zhao, Danhua; Wei, Yuting; Li, Jingbo; Li, Xuefei; Wan, Qiang; Zhang, Xin; Liu, Xiangnan; Yang, Wanchao; Li, Wenzhi

doi:10.1007/s11481-023-10071-0

Cited by 2 publications

(13 citation statements)

References 52 publications

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“…A total of nine studies were included in this study. The five ( Kim et al, 2007 ; Park and Sohrabji, 2016 ; Tu et al, 2017 ; Chen et al, 2019 ; Zhou et al, 2021 ) studies were SD rats with a body weight range of 220–360 g. In total, four ( Kim et al, 2007 ; Tu et al, 2017 ; Chen et al, 2019 ; Zhou et al, 2021 ) studies used animals that were males and one ( Park and Sohrabji, 2016 ) study used animal that was a female; the animals used in two ( Chen et al, 2023 ; Li et al, 2023 ) studies were male C57BL/6 mice with a range of body weights that were not reported; the one ( Sun et al, 2015 ) study used animals that were male ICR mice with a weight range of 22–24 g; the animals used in 1 ( Wang et al, 2021 ) study were male Dd mice, and the body weights of the mice were not reported; nine animal models of occluded middle cerebral arteries were used, including seven MCAO models, one photothrombotic stroke model, and one cerebral I/R injury model. Of the nine studies regarding the control modality, saline control intervention was used in 6 studies, Nacl control intervention was used in 1 study, and 2 studies were not reported.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 5 ( Chen et al, 2019 ; Wang et al, 2021 ; Zhou et al, 2021 ; Chen et al, 2023 ; Li et al, 2023 ) studies reported the percentage of cerebral infarction volume. Heterogeneity was considerable across studies ( p < 0.00001, I 2 = 88%), and a random-effects model was used.…”

Section: Resultsmentioning

confidence: 99%

“…A total of three ( Zhou et al, 2021 ; Chen et al, 2023 ; Li et al, 2023 ) studies reported the foot fault test. There was no heterogeneity across studies ( p = 0.43, I 2 = 0%), and a fixed-effects model was used.…”

Section: Resultsmentioning

confidence: 99%

“…A total of three ( Tu et al, 2017 ; Zhou et al, 2021 ; Li et al, 2023 ) studies reported Morris water maze. Heterogeneity was considerable across studies ( p < 0.05, I 2 = 83%), and a random-effects model was used.…”

Section: Resultsmentioning

confidence: 99%

“…A total of three ( Sun et al, 2015 ; Park and Sohrabji, 2016 ; Li et al, 2023 ) studies reported IL-1β levels in the brain. Heterogeneity across studies was large ( p = 0.04, I 2 = 64%), and a random-effects model was used.…”

Section: Resultsmentioning

confidence: 99%

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Protective effects of butyrate on cerebral ischaemic injury in animal models: a systematic review and meta-analysis

Yan,

Ji,

Ding

et al. 2024

Front. Neurosci.

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IntroductionCerebral ischaemic stroke is a common disease that poses a serious threat to human health. Butyrate is an important metabolite of intestinal microorganisms. Recent studies have shown that butyrate has a significant protective effect in animal models of cerebral ischaemic injury.ObjectiveThe aim of this study was to evaluate the protective effect of butyrate on cerebral ischaemic stroke by meta-analysis, aiming to provide a scientific basis for the clinical application of butyrate in patients with cerebral ischaemia.Materials and methodsA systematic search was conducted for all relevant studies published before 23 January 2024, in PubMed, Web of Science, Cochrane Library, and Embase. Methodological quality was assessed using Syrcle’s risk of bias tool for animal studies. Data were analysed using Rev Man 5.3 software.ResultsA total of nine studies were included, and compared with controls, butyrate significantly increased BDNF levels in the brain (SMD = 2.33, 95%CI = [1.20, 3.47], p < 0.005) and P-Akt expression (SMD = 3.53, 95% CI = [0.97, 6.10], p < 0.05). Butyrate also decreased IL-β levels in the brain (SMD = −2.02, 95% CI = [−3.22, −0.81], p < 0.005), TNF-α levels (SMD = −0.86, 95% CI = [−1.60, −0.12], p < 0.05), and peripheral vascular IL-1β levels (SMD = −2.10, 95%CI = [−3.59, −0.61], p < 0.05). In addition, butyrate reduced cerebral infarct volume (MD = −11.29, 95%CI = [−17.03, −5.54], p < 0.05), mNSS score (MD = −2.86, 95%CI = [−4.12, −1.60], p < 0.005), foot fault score (MD = −7.59, 95%CI = [−9.83, −5, 35], p < 0.005), and Morris water maze time (SMD = −2.49, 95%CI = [−4.42, −0.55], p < 0.05).ConclusionThe results of this study indicate that butyrate has a protective effect on cerebral ischaemic stroke in animal models, and the mechanism is related to reducing inflammation and inhibiting apoptosis. It provides an evidence-based basis for the future clinical development of butyrate in the treatment of ischaemic stroke.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD42023482844.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Protective effects of butyrate on cerebral ischaemic injury in animal models: a systematic review and meta-analysis

Yan,

Ji,

Ding

et al. 2024

Front. Neurosci.

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Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)

Zhang,

Yang,

Hou

et al. 2024

Int J Mol Med

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Stroke, a debilitating cerebrovascular ailment, poses significant threats to human life and health. The intricate interplay between the gut-brain-microbiota axis (GBMA) and cerebral ischemia-reperfusion has increasingly become a focal point of scientific exploration, emerging as a pivotal research avenue in stroke pathophysiology. In the present review, the authors delved into the nexus between the GBMA and neuroinflammation observed post-stroke. The analysis underscored the pivotal roles of histone deacetylase 3 and neutrophil extracellular traps subsequent to stroke incidents. The influence of gut microbial compositions and their metabolites, notably short-chain fatty acids and trimethylamine N-oxide, on neuroinflammatory processes, was further elucidated. The involvement of immune cells, especially regulatory T-cells, and the intricate signaling cascades including cyclic GMP-AMP synthase/stimulator of interferon genes/Toll-like receptor, further emphasized the complex regulatory mechanisms of GBMA in cerebral ischemia/reperfusion injury (CI/RI). Collectively, the present review offered a comprehensive perspective on the metabolic, immune and inflammatory modulations orchestrated by GBMA, augmenting the understanding of its role in neuroinflammation following CI/RI.

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Effect and Mechanism of Sodium Butyrate on Neuronal Recovery and Prognosis in Diabetic Stroke

Cited by 2 publications

References 52 publications

Protective effects of butyrate on cerebral ischaemic injury in animal models: a systematic review and meta-analysis

Protective effects of butyrate on cerebral ischaemic injury in animal models: a systematic review and meta-analysis

Influence of the brain‑gut axis on neuroinflammation in cerebral ischemia‑reperfusion injury (Review)

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