Effect and Mechanism of Herbal Ingredients in Improving Diabetes Mellitus Complications

Ebrahimi, Esmaeel; Shirali, Saeed; Afrisham, Reza

doi:10.5812/jjnpp.31657

Cited by 7 publications

(7 citation statements)

References 51 publications

(18 reference statements)

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“…In addition, 6-week treatment with eupatilin isolated from A. princepes enhanced plasma adiponectin levels and glucose tolerance and decreased fasting blood glucose levels in progressive T2D mice, proving its antidiabetic function, which is similar to the findings of this study [ 29 ]. Adiponectin is an adipokine that improves insulin action and increases glucose uptake in peripheral tissues [ 6 ]. Low serum adiponectin levels are a marker of IR and a risk factor for incidence of T2D [ 25 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms underlying the improvement of IR (ameliorating hyperglycemia, hyperinsulinemia, glucose intolerance, and the HOMA-AD index) in mice with HFD/STZ-induced T2D after 4 weeks of oral treatment with water and alcoholic extracts of AA might be associated with an increase in adiponectin secretion and a decrease in resistin and leptin production from adipocytes. Secondary metabolites, such as flavonoids, alkaloids, and phenols, derived from plants have been used in folk medicine for diabetes mellitus [ 6 ]. AA extracts are abundant in flavonoids [ 16 ], and flavonoids are effective in adiponectin secretion from adipocytes [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Elevated resistin levels in an obesity-induced IR model impaired insulin sensitivity and caused glucose intolerance [ 4 ]. Adiponectin secreted from adipocytes improves insulin sensitivity, increases the glucose usage in peripheral tissues, and stimulates insulin release [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

et al. 2022

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Objectives: Insulin resistance (IR) is major cause of type 2 diabetes (T2D), and adipokines (e.g., adiponectin, leptin, and resistin) play an important role in insulin sensitivity. Medicinal plants are frequently used for T2D treatment. This study investigates the effect of Artemisia annua L. (AA) extracts on adipokines in mice with high-fat-diet (HFD)/streptozotocin (STZ)-induced T2D. Methods: We divided 60 mice into 12 groups (n = 5 per group): control, untreated T2D, treated T2D, and 9 other groups. T2D was induced in all groups, except controls, by 8 weeks of HFD and STZ injection. The treated T2D group was administered 250 mg/kg of metformin (MTF), while the nine other groups were treated with 100, 200, and 400 mg/kg of hot-water extract (HWE), cold-water extract (CWE), and alcoholic extract (ALE) of AA (daily oral gavage) along with 250 mg/kg of MTF for 4 weeks. The intraperitoneal glucose tolerance test (IPGTT) was performed, and the homeostasis model assessment of adiponectin (HOMA-AD) index and blood glucose and serum insulin, leptin, adiponectin, and resistin levels were measured. Results: Similar to MTF, all three types of AA extracts (HWEs, CWEs, and ALEs) significantly (p < 0.0001) decreased the area under the curve (AUC) of glucose during the IPGTT, the HOMA-AD index, blood glucose levels, and serum insulin, leptin, and resistin levels and increased serum adiponectin levels in the MTF group compared to the T2D group (p < 0.0001). The HWEs affected adipokine release, while the CWEs and ALEs decreased leptin and resistin production. Conclusion: Water and alcoholic AA extracts have an antihyperglycemic and antihyperinsulinemic effect on HFD/STZ diabetic mice. In addition, they decrease IR by reducing leptin and resistin production and increasing adiponectin secretion from adipocytes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

et al. 2022

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“…This enzyme delays carbohydrates and prolongs carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently reducing the postprandial rise in plasma glucose 45 . Secondary metabolite compounds such as phenolics, flavonoids, alkaloids, and steroids have antidiabetic activity 46 .…”

Section: Antidiabeticmentioning

confidence: 99%

Pharmacognosy, Phytochemical, and Pharmacology of Wijaya Kusuma (Epiphyllum oxypetalum (DC.) Haw.) – An Update Review

Lesmana

Lusiana²

2022

Borneo J Pharm

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In Indonesia, Epiphyllum oxypetalum (DC.) Haw. is known as Wijaya Kusuma. The plant is grown for home decorating and used widely as medicine in some areas. This narrative review discusses the pharmacognosy, phytochemical, and pharmacology aspects of E. oxypetalum. The review is limited to original articles and abstracts available in Science Direct, PubMed, and Google Scholar. The keyword used to search the articles was “Epiphyllum oxypetalum”. The plant contains proteins, amino acids, alkaloids, saponins, terpenoids, steroids, flavonoids, tannins, glycosides, and resins. The plant has pharmacological activities such as anti-inflammatory, antimicrobials, antidiabetic, and antioxidant properties. Researchers interested in developing E. oxypetalum as a medicinal plant might use this review as a reference.

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“…Although existing research has not sufficiently recognized the impact of and mechanism behind most plant compounds in the treatment of DM, they may work by improving insulin sensitivity, influencing intestinal absorption of glucose, influencing metabolic insulin-dependent processes, enhancing the antioxidant effects of these processes, and stimulating GLUT4 translocation [19][20][21][22][23][24][25][26] .…”

mentioning

confidence: 99%

Antihyperglycemic effect of the alkaloids extracted from Adiantum capillus in diabetic rats

Dizaye¹,

Aziz²

2020

Ann Coll Med Mosul

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Background: Biomedical researches have long sought to develop novel therapies that are more effective, less costly and possess fewer side effects, to treat chronic diseases including diabetes mellitus. Adiantum capillus is among the medicinal plants that have been widely used in traditional medicine and are known to have hypoglycemic effects. This study was designed to find the chemical constituent of Adiantum capillus that exerts the hypoglycemic effect. Materials and Methods: Fifty-four rats were split into nine groups. Twelve normal rats were included in the first group; six acted as negative controls and six were administered Adiantum capillus water extract. The second group was comprised of 42 streptozotocin-induced diabetic rats sectioned into seven subgroups of six rats. The first subgroup functioned as a positive control. The second subgroup was administered 100 mg/kg/day of Adiantum capillus aqueous extract for 21 days, while the third and the fourth subgroup received 50 mg/kg/day of metformin and acarbose respectively. The remaining three groups were administered alkaloids (4 mg/kg/day), flavonoids (24 mg/kg/day) and phenolic compounds (30 mg/kg/day) extracted from Adiantum capillus for 21 days. Fasting blood glucose levels, insulin levels, insulin resistance, serum amylase levels, C-peptide levels, liver function and renal function were monitored. Results: The use of an Adiantum capillus aqueous extract in diabetic rats for 21 days effectively controlled blood glucose levels, elevated amylase level and improved renal and liver function. A significant decrease in blood glucose, AST, ALT, ALP and blood urea levels accompanied by significant increase in the serum amylase of diabetic rats was produced by the alkaloids extracted from Adiantum capillus. However, flavonoids and phenolic compounds did not cause any significant change in blood glucose levels. Conclusion:It can be concluded that the alkaloids extracted from Adiantum capillus are the chemical constituent that contributes to the antihyperglycemic effect of the plant.

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Effect and Mechanism of Herbal Ingredients in Improving Diabetes Mellitus Complications

Cited by 7 publications

References 51 publications

Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

Artemisia annua L. Extracts Improved Insulin Resistance via Changing Adiponectin, Leptin and Resistin Production in HFD/STZ Diabetic Mice

Pharmacognosy, Phytochemical, and Pharmacology of Wijaya Kusuma (Epiphyllum oxypetalum (DC.) Haw.) – An Update Review

Antihyperglycemic effect of the alkaloids extracted from Adiantum capillus in diabetic rats

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