Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia

Zhang, Yi; Jin, Lijun; Liu, Jinchang; Wang, Wei; Yu, Haiyang; Li, Jian; Chen, Qian; Wang, Tao

doi:10.1016/j.jep.2017.12.004

Cited by 76 publications

(66 citation statements)

References 28 publications

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“…For instance, some previous studies have found that high intake of salt was strongly related to HU (33,34). Several metabolic experiments in both animals and humans have proved the effect of high loading of purine on increased serum urate level (31,35,36). Moreover, people who skip breakfast will be hungry and eat a lot of foods rich in protein and purines for lunch, which would accelerate the occurrence of HU (37).…”

Section: Discussionmentioning

confidence: 99%

Prediction model of artificial neural network for the risk of hyperuricemia incorporating dietary risk factors in a Chinese adult study

Zeng¹,

Zhang²,

Li³

et al. 2020

Food & Nutrition Research

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Section: Discussionmentioning

confidence: 99%

Prediction model of artificial neural network for the risk of hyperuricemia incorporating dietary risk factors in a Chinese adult study

Zeng¹,

Zhang²,

Li³

et al. 2020

Food & Nutrition Research

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“…OAT1 and OAT3, localized in the basolateral membrane of proximal tubules, are responsible for uric acid transport from the blood to epithelial cells [ 25 ]. Since more than 90% of the excreted uric acid is reabsorbed and about 10% is excreted in the urine, it is accepted that regulation of uric acid reabsorption plays an important role in uric acid excretion [ 29 , 30 ]. Therefore, URAT1 and GLUT9 are considered attractive therapeutic targets for hyperuricemia.…”

Section: Discussionmentioning

confidence: 99%

DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion

et al. 2018

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Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Presl bark (CB) extracts have been used as the main ingredients in several prescriptions to treat the hyperuricemia and gout in traditional medicine. In the present study, we investigated the antihyperuricemic effects of DKB114, a CF, and CB mixture, and the underlying mechanisms in vitro and in vivo. DKB114 markedly reduced serum uric acid levels in normal rats and rats with PO-induced hyperuricemia, while increasing renal uric acid excretion. Furthermore, it inhibited the activity of xanthine oxidase (XOD) in vitro and in the liver in addition to reducing hepatic uric acid production. DKB114 decreased cellular uric acid uptake in oocytes and HEK293 cells expressing human urate transporter (hURAT)1 and decreased the protein expression levels of urate transporters, URAT1, and glucose transporter, GLUT9, associated with the reabsorption of uric acid in the kidney. DKB114 exerts antihyperuricemic effects and uricosuric effects, which are accompanied, partially, by a reduction in the production of uric acid and promotion of uric acid excretion via the inhibition of XOD activity and reabsorption of uric acid. Therefore, it may have potential as a treatment for hyperuricemia and gout.

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“…Since a long time, the glycoside dioscin ( Figure 23) is known as a weak XO inhibitor with an IC 50 value of 115 μM [94]. Recently, it was evidenced that it has pronounced antihyperuricemic effects in mice by reducing serum UA levels over 4 h at 25 and 50 mg/kg of oral dose [95,96]. is activity can be explained by the regulation of levels of mOAT1, mURAT1, mOCT2, and GLUT-9 expressions in the kidney [95,96].…”

Section: Terpenes and Dioscin Lin Et Al Isolated A Triterpenoidmentioning

confidence: 99%

From Xanthine Oxidase Inhibition to In Vivo Hypouricemic Effect: An Integrated Overview of In Vitro and In Vivo Studies with Focus on Natural Molecules and Analogues

Serrano

Figueiredo

Almeida

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Hyperuricemia is characterized by elevated uric acid (UA) levels on blood, which can lead to gout, a common pathology. These high UA levels are associated with increased purine ingestion and metabolization and/or its decreased excretion. In this field, xanthine oxidase (XO), by converting hypoxanthine and xanthine to UA, plays an important role in hyperuricemia control. Based on limitations and adverse effects associated with the use of allopurinol and febuxostat, the most known approved drugs with XO inhibitory effect, the search for new molecules with XO activity is growing. However, despite the high number of studies, it was found that the majority of tested products with relevant XO inhibition were left out, and no further pharmacological evaluation was performed. Thus, in the present review, available information published in the past six years concerning isolated molecules with in vitro XO inhibition complemented with cytotoxicity evaluation as well as other relevant studies, including in vivo hypouricemic effect, and pharmacokinetic/pharmacodynamic profile was compiled. Interestingly, the analysis of data collected demonstrated that molecules from natural sources or their mimetics and semisynthetic derivatives constitute the majority of compounds being explored at the moment by means of in vitro and in vivo animal studies. Therefore, several of these molecules can be useful as lead compounds and some of them can even have the potential to be considered in the future clinical candidates for the treatment of hyperuricemia.

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Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia

Cited by 76 publications

References 28 publications

Prediction model of artificial neural network for the risk of hyperuricemia incorporating dietary risk factors in a Chinese adult study

Prediction model of artificial neural network for the risk of hyperuricemia incorporating dietary risk factors in a Chinese adult study

DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion

From Xanthine Oxidase Inhibition to In Vivo Hypouricemic Effect: An Integrated Overview of In Vitro and In Vivo Studies with Focus on Natural Molecules and Analogues

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