Effect and mechanism of “Danggui–kushen” herb pair on ischemic heart disease

Li, Hui; Dong, Pei liang; Yu, Xiao jin; Li, Qing na; Liu, Jia qi; Liu, Cai yan; Han, Ho Jae

doi:10.1016/j.biopha.2021.112450

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Therefore, in recent years, an increasing number of studies have used various methods to identify the synergistic mechanisms of potentially useful herb-pairs [ 123 , 124 , 125 ]. A previous study using a combination of network pharmacology and bioinformatics reported that Astragali Radix, which was also used in this study, could form a promising herbal pair for the treatment of DPN with Notoginseng Radix [ 126 , 127 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Efficacy of East Asian Herbal Formulae Containing Astragali Radix–Cinnamomi Ramulus Herb-Pair against Diabetic Peripheral Neuropathy and Mechanism Prediction: A Bayesian Network Meta-Analysis Integrated with Network Pharmacology

Baek²,

Lee

2023

Pharmaceutics

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The Astragali Radix–Cinnamomi Ramulus herb-pair (ACP) has been widely used in the treatment of diabetic peripheral neuropathy (DPN) as part of East Asian herbal medicine (EAHM). Eligible randomized controlled trials (RCTs) were identified by searching 10 databases. The outcomes investigated were response rate, sensory nerve conduction velocity (SNCV), and motor nerve conduction velocity (MNCV) in four regions of the body. The compounds in the ACP and their targets of action, disease targets, common targets, and other relevant information were filtered using network pharmacology. Forty-eight RCTs, with 4308 participants, and 16 different interventions were identified. Significant differences were observed in the response rate, MNCV, and SNCV, as all EAHM interventions were superior to conventional medicine or lifestyle modification. The EAHM formula containing the ACP ranked highest in more than half of the assessed outcomes. Furthermore, major compounds, such as quercetin, kaempferol, isorhamnetin, formononetin, and beta-sitosterol, were found to suppress the symptoms of DPN. The results of this study suggest that EAHM may increase therapeutic efficacy in DPN management, and EAHM formulations containing the ACP may be more suitable for improving treatment response rates to NCV and DPN therapy.

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Section: Discussionmentioning

confidence: 99%

Comparative Efficacy of East Asian Herbal Formulae Containing Astragali Radix–Cinnamomi Ramulus Herb-Pair against Diabetic Peripheral Neuropathy and Mechanism Prediction: A Bayesian Network Meta-Analysis Integrated with Network Pharmacology

Baek²,

Lee

2023

Pharmaceutics

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“…Myocardial ischemic injury is a common pathological feature of ischemic heart disease, which can reduce the activity of cardiomyocytes and vascular endothelial cells [ 21 ] and increase the size of myocardial infarction. Previous studies have shown that “Danggui-Kushen” herb pair has important functions such as reducing infarct size, protecting blood vessels, promoting vascular reconstruction, and anti-inflammation in ischemic heart disease [ 21 ]. This is consistent with the results of our research.…”

Section: Discussionmentioning

confidence: 99%

Protective effect and mechanism of different proportions of “Danggui-Kushen” herb pair on ischemic heart disease

Yuan,

Liu,

Dong

et al. 2023

Heliyon

Self Cite

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“…DBD consists of dried Astragali radix (dried root of Astragalus mongholicus Bunge) and Angelica sinensis (dried root of Angelica sinensis Diels) in a mass ratio of 5:1, and is commonly used for its blood-tonifying effects (Hua et al, 2019;Tie et al, 2022). DBD has shown promising therapeutic outcomes in patients with focal cerebral ischemia, ischemic heart disease, and diabetic atherosclerosis (Zhang et al, 2006;Dong et al, 2022;Dou et al, 2023), and particularly in treating BDS (Shi et al, 2014). DBD contains abundant chemical constituents, notably, organic acids, saponins, volatile oils, and flavonoids, which may be active in BDS treatment (Shi et al, 2014;Liu et al, 2019;Chen T. et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Chinmedomics strategy for elucidating the effects and effective constituents of Danggui Buxue Decoction in treating blood deficiency syndrome

Zhang,

Yang,

Ren

et al. 2024

Front. Mol. Biosci.

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Introduction:Danggui Buxue Decoction (DBD) is a clinically proven, effective, classical traditional Chinese medicine (TCM) formula for treating blood deficiency syndrome (BDS). However, its effects and effective constituents in the treatment of BDS remain unclear, limiting precise clinical therapy and quality control. This study aimed to accurately evaluate the effects of DBD and identify its effective constituents and quality markers.Methods:BDS was induced in rats by a combined injection of acetylphenylhydrazine and cyclophosphamide, and the efficacy of DBD against BDS was evaluated based on body weight, body temperature, energy metabolism, general status, visceral indices, histopathology, biochemical markers, and metabolomics. The effects of DBD on urinary and serum biomarkers of BDS were investigated, and the associated metabolic pathways were analyzed via metabolomics. Guided by Chinmedomics, the effective constituents and quality markers of DBD were identified by analyzing the dynamic links between metabolic biomarkers and effective constituents in vivo.Results:DBD improved energy metabolism, restored peripheral blood and serum biochemical indices, and meliorated tissue damage in rats with BDS. Correlation analyses between biochemical indices and biomarkers showed that 15(S)-HPETE, LTB4, and taurine were core biomakers and that arachidonic acid, taurine, and hypotaurine metabolism were core metabolic pathways regulated by DBD. Calycosin-7-glucoside, coumarin, ferulic acid sulfate, cycloastragenol, (Z)-ligustilide + O, astragaloside IV, acetylastragaloside I, and linoleic acid were identified as effective constituents improving the hematopoietic function of the rats in the BDS model. Additionally, calycosin-7-glucoside, ferulic acid, ligustilide, and astragaloside IV were identified as quality markers of DBD.Conclusion:The hematopoietic function of DBD was confirmed through analysis of energy metabolism, biochemical markers, histopathology, and metabolomics. Moreover, by elucidating effective constituents of DBD in BDS treatment, quality markers were confirmed using a Chinmedomics strategy. These results strengthen the quality management of DBD and will facilitate drug innovation.

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Effect and mechanism of “Danggui–kushen” herb pair on ischemic heart disease

Cited by 7 publications

References 15 publications

Comparative Efficacy of East Asian Herbal Formulae Containing Astragali Radix–Cinnamomi Ramulus Herb-Pair against Diabetic Peripheral Neuropathy and Mechanism Prediction: A Bayesian Network Meta-Analysis Integrated with Network Pharmacology

Comparative Efficacy of East Asian Herbal Formulae Containing Astragali Radix–Cinnamomi Ramulus Herb-Pair against Diabetic Peripheral Neuropathy and Mechanism Prediction: A Bayesian Network Meta-Analysis Integrated with Network Pharmacology

Protective effect and mechanism of different proportions of “Danggui-Kushen” herb pair on ischemic heart disease

Chinmedomics strategy for elucidating the effects and effective constituents of Danggui Buxue Decoction in treating blood deficiency syndrome

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