Effect and Mechanism of Acupuncture on Gastrointestinal Diseases

Takahashi, Toshio

doi:10.1016/b978-0-12-411545-3.00014-6

Cited by 41 publications

(32 citation statements)

References 115 publications

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“…In recent years, some studies demonstrated that acupuncture could stimulate the release of peptidergic neurotransmitters, including MTL, and activate the peptidergic neural pathway to promote the recovery of inhibited gastric myoelectric activity25. The present study also found that on the 3 rd and 7 th days, the intra-abdominal pressure in the intervention group was obviously lower than in the control group and that the incidence of abdominal compartment syndrome was decreased, leading to improved gastrointestinal function of patients with severe sepsis.…”

Section: Discussionmentioning

confidence: 99%

Early traditional Chinese medicine bundle therapy for the prevention of sepsis acute gastrointestinal injury in elderly patients with severe sepsis

Wang¹,

Zhang²,

Jiang

2017

Sci Rep

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This study aimed to study the effect of early traditional Chinese medicine bundle therapy on the prevention of sepsis-associated acute gastrointestinal injury (AGI). This was a multicenter, prospective, observational, non-randomized cohort study of 296 consecutive patients with severe sepsis during 2013/3 and 2014/11; 150 patients received standard treatments (controls) and 146 received traditional Chinese medicine bundle therapy (intervention group) (herbal decoction gavage based on syndrome differentiation, Chinese acupuncture, application of mirabilite, and defecation mixture). D-lactic acid, diamine oxidase, endotoxin, gastrin, motilin, and intra-abdominal pressure were measured. AGI was categorized into four levels. Compared with controls, D-lactic acid, diamine oxidase, endotoxin, gastrin, and intra-abdominal pressure in the intervention group were decreased, and motilin was increased on day 7. AGI incidence in the intervention group was lower than in controls. GIF scores of the intervention AGI II and III groups were lower than in controls. The APACHE II scores of the intervention AGI II, III, and IV groups were lower than in controls. Compared with controls, mechanical ventilation time and ICU stay in the intervention group were shorter, and 28-day overall and AGI-attributed mortality were lower. For elderly patients with severe sepsis, early traditional Chinese medicine bundle therapy could decrease AGI incidence and improve prognosis.

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Section: Discussionmentioning

confidence: 99%

Early traditional Chinese medicine bundle therapy for the prevention of sepsis acute gastrointestinal injury in elderly patients with severe sepsis

Wang¹,

Zhang²,

Jiang

2017

Sci Rep

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“…Acupuncture restores the balance of parasympathetic and sympathetic nerves, the disturbance of which is considered to be the sole cause of gastrointestinal dysmotility in diabetes mellitus (18,19). In addition, EA has been demonstrated to modulate gastric motility through regulating the expression of transient receptor potential vanilloid 1, a Ca 2+ -permeable non-selective cation channel that has important physiological functions in peripheral and central nervous systems (20,21).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, EA has been demonstrated to modulate gastric motility through regulating the expression of transient receptor potential vanilloid 1, a Ca 2+ -permeable non-selective cation channel that has important physiological functions in peripheral and central nervous systems (20,21). In recent decades, numerous studies on patients and animals have been performed to elucidate the effects of acupuncture on gastric myoelectrical activity as well as the underlying mechanisms (4)(5)(6)(7)(8)(9)(10)(11)(12)(18)(19)(20)(21)(22)(23)(24). However, the exact mechanisms by which acupuncture improves gastric motility and dyspeptic symptoms have yet to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis

Pan

Wang

Tian

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study compared the clinical effectiveness of electroacupuncture (EA), monotherapy and combination therapy involving the administration of EA and mosapride in diabetic patients with severe or mild symptoms suggestive of gastroparesis. A total of 56 patients with type 2 diabetes who had symptoms suggestive of gastroparesis for >3 months were divided into two groups according to the Gastroparesis Cardinal Symptom Index (GCSI) score, including 33 in the mild group (GCSI score <3.5) and 23 in the severe group (GCSI score ≥3.5). Initially, all patients received EA monotherapy for 14 days. An effective response was defined as a reduction of the overall baseline GCSI score by >25% after treatment. The non-responding patients then received a combination treatment with EA and mosapride. Gastric emptying was assessed by the 13 C-octanoic acid breath test at the beginning and end of each treatment session. Two patients in the severe group dropped out of the study during the initial treatment session. The results revealed that 34 early-responding patients (30 from the mild group and 4 from the severe group) treated with EA monotherapy, and 20 non-early-responding patients receiving combination therapy with EA and mosapride showed clinically significant improvements. Analysis of data from the mild subgroup demonstrated that EA treatment specifically improved symptoms of nausea, vomiting, stomach fullness, excessive fullness and bloating. There was no statistically significant difference in the gastric half-emptying time among patients prior to and after EA monotherapy. These preliminary results suggested that EA may be an option for improving mild symptoms in patients with diabetic gastroparesis, whereas combination therapy involving EA and pharmaceutics is required in patients with severe symptoms.

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“…The present study showed that on the 3 rd and 7 th day after admission, MTL in the intervention group was higher than in the control group, and GAS in the intervention group was lower than in the control group, strongly suggesting that TCM bundle therapy can significantly improve the secretion of gastrointestinal hormones in patient with severe sepsis and should help maintaining the gastrointestinal functions. In recent years, some studies demonstrated that acupuncture could stimulate the release of peptidergic neurotransmitters including MTL, and activate the peptidergic neural pathway to play a role and promote the recovery of inhibited gastric myoelectric activity [22]. The present study also found that at on the 3 rd and 7 th days, the intra-abdominal pressure in the intervention group was obviously lower than in the control group and that the incidence of abdominal compartment syndrome was decreased, leading to improved gastrointestinal function of patient with severe sepsis.…”

Section: Discussionmentioning

confidence: 99%

Early Traditional Chinese Medicine Bundle Therapy for the Prevention of Sepsis Acute Gastrointestinal Injury in Patients with Severe Sepsis

Jiang¹

2017

IJCAM

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To study the role of early traditional Chinese medicine bundle therapy on the prevention of sepsis-associated acute gastrointestinal injury (AGI). This was a multicenter, prospective cohort study of 296 consecutive patients with severe sepsis between 2013/3 and 2014/11; 150 patients received standard treatments (controls) and 146 received traditional Chinese medicine bundle therapy (intervention group) (herbal decoction gavage based on syndrome differentiation, acupuncture, application of mirabilite, and defecation mixture). D-lactic acid, diamine oxidase, endotoxin, gastrin, and intra-abdominal pressure were measured. AGI was classified into four levels. Compared with controls, D-lactic acid, diamine oxidase, endotoxin, gastrin, and intra-abdominal pressure in the intervention group were decreased and motilin was increased on day 7 (P<0.05). AGI incidence in the intervention group was lower than in controls (P<0.05). GIF scores of the intervention AGI II and III groups were lower than in controls (P<0.05). The APACHE II scores of intervention AGI II, III, and IV groups were lower than in controls (P<0.05). Compared with controls, mechanical ventilation time and ICU stay in the intervention group were shorter ( P=0.011 and P=0.035); and 28-day overall and AGI-attributed mortality were lower (P=0.048 and P=0.043). For patients with severe sepsis, early traditional Chinese medicine bundle therapy could decrease AGI incidence and improve prognosis.

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Effect and Mechanism of Acupuncture on Gastrointestinal Diseases

Cited by 41 publications

References 115 publications

Early traditional Chinese medicine bundle therapy for the prevention of sepsis acute gastrointestinal injury in elderly patients with severe sepsis

Early traditional Chinese medicine bundle therapy for the prevention of sepsis acute gastrointestinal injury in elderly patients with severe sepsis

Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis

Early Traditional Chinese Medicine Bundle Therapy for the Prevention of Sepsis Acute Gastrointestinal Injury in Patients with Severe Sepsis

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