Abstract:Summary. The effect of a single subcutaneous injection of monocrotaline on the right atrial muscle cells of rats was examined by electron microscopy. Particular attention was paid to changes in the number of specific atrial granules containing atrial natriuretic polypeptide, and to the degree of development of the Golgi apparatus in the cells induced by the drug.The effect of the drug was maximum at 5 weeks after injection of 60 mg/kg monocrotaline. The Golgi apparatuses were markedly developed, and an increas… Show more
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