Efektivitas Pemberian Ekstrak Jahe Merah (Zingiber Officinale) Terhadap Jumlah Sel Fibroblas Dalam Proses Penyembuhan Ulkus Pada Mukosa Mulut Tikus Putih Jantan (Rattus Norvegicus)

Abstract

Background: In the wound healing process there are a variety of processes, including the most important are fibroplasia process that has a very important role in the wound healing process. Red ginger (Zingiber officinale) contains active ingredients include a mixture of components of essential oils and resins that oleoresin which has anti-inflammatory effects. The aim is determine the effect of red ginger extract against the number of fibroblasts in healing ulcers on the oral mucosa white male rats (Rattus norvegicus) Method: Samples using 24 male rats 2-3 months of age and body weight of 120-200 grams. Mandibular labial mucosa injured mice using H2O2 solution for 2x1 days. The samples were divided into 4 groups, where each group each of 4 individuals: group 1 without any treatment, group 2 was treated application ginger gel extract 4%, group 3 was given treatment application ginger gel extract 8% and group 4 treated with applications aloclair gel. On the fourth day after the injury, the rats were decapitated, then do making preparations for histology to count the number of fibroblast cells. Result:The results Oneway ANOVA p value <0.05 and post Hoc Test LSD p value <0.05 which means that the extract of red ginger significantly affects the number of fibroblast cells and between groups have significant differences Conclusion: Extract red ginger gel is effective against the number of fibroblasts in healing ulcers on the oral mucosa white male rats.

The effect of cinnamon (Cinnamomum burmannii) leaf extract gel on the number of fibroblasts in healing inflammation of the oral mucosa of white wistar

“…Hal ini menandakan bahwa proses penyembuhan luka dapat terjadi secara alami yang ditandai dengan peningkatan skor indikator penyembuhan luka seperti pembentukan kolagen, vaskularisasi, fibrosis dan epitelisasi. 28,29 Kelompok perlakuan memperlihatkan bahwa pemberian aplikasi gel ekstrak DKM 35% dapat meningkatkan jumlah sel fibroblas. Hal ini dikarenakan kandungan senyawa metabolit sekunder seperti flavonoid, alkaloid, dan tanin yang diaplikasikan pada radang mukosa bukal tikus putih dapat merangsang faktor pertumbuhan fibroblast growth factor (FGF) yang dapat meningkatkan aktivitas sel fibroblas untuk memproduksi kolagen dan membentuk jaringan ikat sehingga luka akan mengalami penyembuhan dengan cepat.…”

Molecular characterization of red ginger varieties (Zingiber officinale Roxb. var. rubrum) by DNA markers

“…The Indonesian population has historically used red ginger as a remedy for colds and back discomfort (FROTI 2017). This plant exhibits a range of pharmacological properties, including analgesic, wound healing, antibacterial, and antioxidant effects (Agusmawanti 2016;Febriani et al 2018;Pratoko et al 2018;Saptiwi et al 2018).…”

UJI EFEKTIVITAS EKSTRAK ETANOL DAUN JAMBU BIJI MERAH (Psidium guajava L.) DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Porphyromonas gingivalis PENYEBAB PERIODONTITIS

“…5 Namun, penggunaan antibiotik dengan durasi yang tidak tepat dapat menyebabkan terjadinya resistensi antibiotik. 6 Pemanfaatan potensi tumbuhan atau etnobotani sudah menjadi bagian dari kehidupan masyarakat di Indonesia. Keadaan ini didukung oleh keanekaragaman hayati yang berasal dari berbagai ekosistem yang ada di Indonesia.…”